【摘要】：肌源性干細(xì)胞(muscle-derived stem cells,MDSC)是具有多胚層分化潛能和自我更新能力的成體干細(xì)胞群,在造血微環(huán)境的誘導(dǎo)下可分化為造血細(xì)胞,其造血能力是骨髓造血干細(xì)胞的10-14倍,有望成為替代造血干細(xì)胞治療某些骨髓疾患或腫瘤的備選干細(xì)胞之一,但在造血微環(huán)境下MDSC向造血細(xì)胞轉(zhuǎn)化的機(jī)制還不十分清晰。MDSC與造血干細(xì)胞在生物學(xué)特性、蛋白表達(dá)和細(xì)胞增殖方面有明顯差別。此外,MDSC中存在不同分化潛能的干細(xì)胞群,但其中具有造血分化潛能較少,而且與造血干細(xì)胞起源是否相同還有待進(jìn)一步研究。本文主要就MDSC中有造血分化潛能的細(xì)胞群的分子表型、MDSC與造血干細(xì)胞區(qū)別、MDSC的起源及其應(yīng)用前景做一綜述。
[Abstract]:Myogenic stem cells (muscle-derived stem cells,MDSC) are adult stem cells with multi-embryonic differentiation potential and self-renewal ability. They can differentiate into hematopoietic cells under the induction of hematopoietic microenvironment, and their hematopoietic ability is 10 鈮，

本文編號：2516107