【摘要】：五羥色胺是一種重要的神經(jīng)遞質(zhì),可以調(diào)控動(dòng)物許多生理過程。當(dāng)雄性小鼠失去所有的五羥色胺神經(jīng)元時(shí)會(huì)發(fā)生強(qiáng)烈的同性交配行為。這些突變小鼠對(duì)雄性和雌性小鼠都會(huì)發(fā)出30-110KHz的超聲波,而野生型小鼠只對(duì)雌性發(fā)出超聲波。在同時(shí)有雄鼠和發(fā)情雌鼠的時(shí)候,野生型小鼠表現(xiàn)出對(duì)雌鼠強(qiáng)烈的交配傾向,而突變小鼠則對(duì)雄鼠和雌鼠表現(xiàn)出同等的交配傾向。在正常小鼠上用藥物副氯苯丙氨酸(PCPA)阻斷五羥色胺的合成也能得到相似的現(xiàn)象這表明突變體小鼠的表形不是因?yàn)榘l(fā)育的缺陷或遺產(chǎn)背景差異而引起的。墊料的傾向性實(shí)驗(yàn)表明五羥色胺降低的小鼠對(duì)雌性和雄性小鼠的氣味失去了偏好,正常的雄鼠則偏好雌鼠的味道,提示突變體小鼠的同性交配行為是由于對(duì)兩性的偏好紊亂。小鼠的性別辨認(rèn)主要是通過嗅覺,但突變體小鼠基于嗅覺的社會(huì)識(shí)別和社會(huì)記憶都是正常的,這表明五羥色胺不是通過嗅覺來影響交配。突變體小鼠的味覺和社會(huì)性趨近行為都正常。這些結(jié)果說明五羥色胺在雄性小鼠的性偏好的高級(jí)中樞起重要作用。 野生型幼鼠在與母鼠分開后放在一個(gè)干凈不保溫的環(huán)境時(shí)發(fā)出強(qiáng)烈的超聲波,而五羥色胺敲除小鼠在同樣狀態(tài)下發(fā)出的超聲波大為減少。雄性的突變體和野生型幼鼠發(fā)出超聲波的潛伏期接近,而雌性的突變體幼鼠發(fā)出超聲波的潛伏期要長(zhǎng)于野生型。突變體幼鼠發(fā)出超聲波的強(qiáng)度比野生型幼鼠也有很大的減少。突變體幼鼠對(duì)母鼠的氣味的傾向性比野生型幼鼠有所降低。這表明五羥色胺在幼鼠的情緒及幼鼠對(duì)母鼠的依戀方面有重要作用。
[Abstract]:Serotonin is an important neurotransmitter that regulates many physiological processes in animals. Strong same-sex mating occurs when male mice lose all serotonin neurons. These mutant mice send 30-110KHz ultrasound to both male and female mice, while wild-type mice only send ultrasound to females. When there were both male and female estrous mice, wild mice showed strong mating tendency to female mice, while mutant mice showed the same mating tendency to male and female mice. A similar phenomenon could be obtained by blocking the synthesis of serotonin with (PCPA) in normal mice, which indicated that the surface shape of mutant mice was not caused by developmental defects or heritage background differences. The bias test of gasket showed that the mice with decreased serotonin lost their preference for the smell of both female and male mice, while the normal male mice preferred the taste of female mice, suggesting that the heterosexual mating behavior of mutant mice was due to the disorder of preference for both sexes. The sex recognition of mice is mainly through olfactory, but the social recognition and social memory of mutant mice based on olfaction are normal, which indicates that serotonin does not affect mating by olfaction. The taste and social convergence behaviors of mutant mice were normal. These results suggest that serotonin plays an important role in the higher center of sexual preference in male mice. Young wild mice emit intense ultrasound in a clean and uninsulated environment after being separated from their mothers, while serotonin knockout mice emit less ultrasound in the same state. The latency of ultrasound in male mutants was similar to that in wild type mice, while that of female mutants was longer than that of wild type. The ultrasound intensity of the mutant pups was also significantly lower than that of wild type pups. The smell tendency of the mutants was lower than that of wild mice. This suggests that serotonin plays an important role in the mood and attachment of young rats to their mothers.
【學(xué)位授予單位】：北京協(xié)和醫(yī)學(xué)院
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2008
【分類號(hào)】：R346

【共引文獻(xiàn)】

相關(guān)期刊論文 前3條

1 Fabrizio COSTANTINI;Francesca R. D’AMATO;;鼠類超聲波通訊的社會(huì)原因和功能(英文)[J];動(dòng)物學(xué)報(bào);2006年04期

2 張琳;楊福合;邢秀梅;;產(chǎn)箱環(huán)境對(duì)母貂母性行為和仔貂生長(zhǎng)發(fā)育的影響[J];中國(guó)畜牧獸醫(yī);2011年08期

3 劉惠芬,周文華;焦慮的生物學(xué)機(jī)制[J];中國(guó)藥物濫用防治雜志;2000年06期

相關(guān)碩士學(xué)位論文 前4條

1 王曉蕾;甘麥大棗湯抗焦慮作用及機(jī)制研究[D];黑龍江中醫(yī)藥大學(xué);2010年

2 米曉娟;青藤堿的抗焦慮作用研究[D];沈陽藥科大學(xué);2005年

3 李位景;化合物DAP的抗焦慮作用研究[D];沈陽藥科大學(xué);2006年

4 王迪;基于三維結(jié)構(gòu)的雙特異性蛋白激酶(Dyrk1A)抑制劑篩選及其活性的初步研究[D];第二軍醫(yī)大學(xué);2009年

，

本文編號(hào)：2344693