本文選題：連翹酯苷 + 解熱　； 參考：《中藥藥理與臨床》2015年01期

【摘要】：目的:考察連翹酯苷不同給藥途徑對(duì)副流感病毒致熱家發(fā)熱模型解熱作用的影響。方法:將連翹酯苷分別以靜脈注射和口服灌胃的途徑對(duì)副流感病毒感染家兔發(fā)熱的模型進(jìn)行治療性給藥,靜脈注射途徑觀察給藥后0.5h、1h、2h的解熱作用,口服灌胃途徑觀察給藥后1h、2h、3h的解熱作用,并檢測(cè)各組動(dòng)物下丘腦中發(fā)熱介質(zhì)蛋白激酶C(PKC)和環(huán)磷酸腺苷(c AMP)的含量。結(jié)果:靜脈注射連翹酯苷(60mg/kg、120mg/kg)0.5h后家兔體溫差值為(0.72±0.26)、(0.83±0.24)℃,1h后體溫差值為(0.82±0.23)、(0.92±0.34)℃,灌胃給予連翹酯苷(60mg/kg、120mg/kg)后1h家兔的體溫差值為(0.43±0.42)、(0.45±0.42)℃,與模型比較均具有顯著差異,起效劑量為60mg/kg。靜脈注射連翹酯苷(30mg/kg、60mg/kg、120mg/kg)均能降低家兔下丘腦中環(huán)磷酸腺苷含量,分別為(13.92±9.11)、(16.47±7.98)、(19.75±5.04)nmol/L,灌胃給予相應(yīng)劑量的連翹酯苷則對(duì)發(fā)熱介質(zhì)無影響。結(jié)論:連翹酯苷靜脈注射和口服灌胃均能明顯降低副流感病毒感染后家兔的體溫,且靜脈注射的解熱作用要優(yōu)于口服灌胃,其解熱作用機(jī)制可能與下調(diào)家兔下丘腦組織中的c AMP含量有關(guān)。
[Abstract]:Aim: to investigate the antipyretic effect of forsythrin on parainfluenza virus fever model. Methods: the model of parainfluenza virus infection in rabbits was treated with phillyrin by intravenous injection and oral administration respectively. The antipyretic effect was observed by intravenous injection at 0.5 h or 1 h after administration. The antipyretic effect was observed 1 h after administration by oral gavage, and the contents of hypothalamus protein kinase (PKC) and cyclic adenosine monophosphate (AMP) in hypothalamus were measured. Results: the body temperature difference of rabbits was 0.72 鹵0.26 鹵0.24 鈩，

本文編號(hào)：2004038