本文關(guān)鍵詞： 阿爾茲海默病 丹參 三氯化鋁 乙酰膽堿酯酶　出處：《實(shí)驗(yàn)動(dòng)物科學(xué)》2014年04期 　論文類型：期刊論文

【摘要】：目的觀察丹參對(duì)三氯化鋁(AlCl3)所致的阿爾茲海默病(AD)模型小鼠學(xué)習(xí)記憶能力的影響及其腦組織和血清中乙酰膽堿酯酶(AchE)含量的變化。方法 AD模型組:給小鼠每日按400 mg/kg灌胃4%的AlCl3溶液,連續(xù)灌胃60 d。正常對(duì)照組:每日灌胃與AlCl3等同劑量的生理鹽水。丹參治療組:每日灌胃AlCl3+丹參溶液1 mL。丹參對(duì)照組:每日只灌胃丹參溶液1 mL。實(shí)驗(yàn)周期為60 d。給藥結(jié)束后進(jìn)行Morris水迷宮訓(xùn)練,24 h后進(jìn)行學(xué)習(xí)記憶功能測(cè)試和乙酰膽堿酯酶含量的測(cè)定。結(jié)果丹參治療組、丹參對(duì)照組與正常對(duì)照組比較,小鼠的逃避潛伏期以及其腦組織和血清中的乙酰膽堿酯酶含量無(wú)明顯變化,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。與模型組小鼠比較,丹參治療組小鼠的逃避潛伏期明顯縮短(P0.05),并且其腦組織和血清中的乙酰膽堿酯酶含量比模型組明顯降低(P0.05)。結(jié)論丹參能有效降低AlCl3致AD模型小鼠腦內(nèi)及血清中膽堿酯酶活性,明顯改善AD模型小鼠的學(xué)習(xí)記憶功能,這可能是丹參可防治阿爾茲海默病的機(jī)制之一。
[Abstract]:Objective to observe the effect of Salvia miltiorrhiza on learning and memory ability and acetylcholinesterase (ache) in brain tissue and serum of mice with Alzheimer's disease induced by AlCl3). Methods in AD model group, the mice were given 4% AlCl3 solution at 400 mg/kg per day. For 60 days, the normal control group was given the same dose of normal saline as AlCl3 daily. The salvia miltiorrhiza treated group was given AlCl3 Salvia miltiorrhiza solution 1 mL daily. The control group was treated with Salvia miltiorrhiza. Only 1 mL of Salvia miltiorrhiza solution was administered daily for 60 days. Morris water maze training was performed after administration. After 24 hours, the function of learning and memory and the content of acetylcholinesterase were measured. Results compared with the normal control group, the salvia miltiorrhiza treatment group and the salvia miltiorrhiza control group. The escape latency and the content of acetylcholinesterase in brain tissue and serum of mice showed no significant change, but the difference was not statistically significant (P 0.05). The escape latency of salvia miltiorrhiza treated mice was shortened significantly (P0.05). The content of acetylcholinesterase in brain tissue and serum was significantly lower than that in model group. Conclusion Salvia miltiorrhiza can effectively reduce the activity of cholinesterase in brain and serum of AD model mice induced by AlCl3. It may be one of the mechanisms that Salvia miltiorrhiza can prevent and treat Alzheimer's disease.
【作者單位】： 長(zhǎng)沙醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院;
【基金】：長(zhǎng)沙醫(yī)學(xué)院大學(xué)生研究性學(xué)習(xí)和創(chuàng)新性實(shí)驗(yàn)資助項(xiàng)目(長(zhǎng)醫(yī)教[2012]21號(hào)) 湖南省衛(wèi)生廳一般項(xiàng)目(No.B2013-059) 湖南省教育廳一般項(xiàng)目(No.12C0509)
【分類號(hào)】：R749.16
【正文快照】： 阿爾茲海默病(Alzheimers disease,AD)是一種與年齡相關(guān)的中樞神經(jīng)系統(tǒng)退行性病變[1],發(fā)病率較高,已成為現(xiàn)代社會(huì)嚴(yán)重威脅老年人生命的疾病之一,其死亡率僅次于心血管疾病、癌癥及中風(fēng)而位居第四[2]。鋁是一種慢性神經(jīng)毒物,可在腦組織中蓄積,干擾腦細(xì)胞活動(dòng),破壞神經(jīng)元結(jié)構(gòu),導(dǎo)，

本文編號(hào)：1444834