本文關鍵詞：嗅小球電生理網(wǎng)絡建模及平臺期型球周圍細胞功能研究　出處：《浙江大學》2013年碩士論文　論文類型：學位論文

  更多相關文章： 嗅小球 網(wǎng)絡建模 電生理 平臺期電位 球周圍細胞

【摘要】：在嗅覺系統(tǒng)中,嗅球是嗅覺信息在大量傳送到各種次級結構之前的最后處理階段,是對嗅覺信息進行整合和編碼的重要部位,因而對嗅球電生理的研究是了解嗅覺系統(tǒng)信息編碼機制的基礎。嗅球上的嗅小球中包含很多對嗅覺信息輸入執(zhí)行多種、不同操作的復雜微網(wǎng)絡,在嗅覺信息處理中起著重要的作用。球周圍細胞是參與嗅小球回路的重要中間神經(jīng)元,它們在嗅覺信息處理中所起的功能還有待研究。球周圍細胞存在很多亞類,不同亞類在功能上也存在差異,其中一個亞類在刺激下發(fā)放平臺期電位。平臺期電位型球周圍細胞具有能夠將嗅感覺神經(jīng)元軸突的高頻輸入轉化為低頻輸出的特性,很有可能參與了調控嗅小球活動的時序模式,這類細胞正逐步引起人們的注意。本論文建立了一個包含平臺期型球周圍細胞、僧帽細胞及細胞間突觸聯(lián)結的嗅小球網(wǎng)絡模型,為研究嗅小球回路在嗅覺信息編碼中的作用提供研究平臺,并初步分析發(fā)放平臺期電位的球周圍細胞在嗅小球網(wǎng)絡中的作用。 本論文首先簡要介紹了嗅覺產生機理與嗅球解剖結構,詳細介紹了嗅小球及其模型研究現(xiàn)狀,并對球周圍細胞的生理特性及其建模進展進行了介紹；其次,詳細介紹了建立的嗅小球網(wǎng)絡模型所采用的神經(jīng)元電纜模型、離子通道動力學模型、神經(jīng)突觸動力學模型以及建模工具軟件；再次,介紹了網(wǎng)絡模型中加入的各類細胞模型以及各類突觸模型的參數(shù)設置,并對網(wǎng)絡的拓撲結構進行了介紹；最后,在網(wǎng)絡模型的基礎上,初步分析研究了平臺期型球周圍細胞的作用,發(fā)現(xiàn)平臺期型球周圍細胞對投射到同一個嗅小球中的僧帽細胞的峰值發(fā)放同步有作用。 本論文建立的嗅小球電生理網(wǎng)絡模型為嗅覺神經(jīng)系統(tǒng)編碼的理論研究提供了一個良好的平臺,同時本論文的研究結果,為下一步對嗅覺神經(jīng)系統(tǒng)編碼理論的深入研究打下了良好的基礎。
[Abstract]:In olfactory system, olfactory bulb is the final processing stage of olfactory information before it is transferred to various secondary structures, and it is an important part of olfactory information integration and coding. Therefore, the study of olfactory bulb electrophysiology is the basis of understanding the olfactory system information coding mechanism. The olfactory bulb on the olfactory bulb contains many complex micronetworks which perform many different operations on olfactory information input. It plays an important role in the processing of olfactory information. Perigloboid cells are important intermediate neurons involved in the loop of olfactory pellets. Their functions in olfactory information processing still need to be studied. There are many subtypes in peribulbar cells, and different subclasses have different functions. One of the subclasses distributes the plateau potential under stimulation. The cells around the globus have the ability to convert the high-frequency inputs of the axons of the olfactory sensory neurons into low-frequency outputs. It is very likely that these cells are involved in the timing pattern of olfactory pellet activity, which is gradually attracting attention. In this paper, we have established a cell that contains the platform-type periglobule. The model of olfactory pellet network with synaptic connection between mitral cells and cells provides a platform for studying the role of olfactory globule loop in olfactory information coding. The role of peripheral cells in the network of olfactory pellets was preliminarily analyzed. In this paper, the mechanism of olfactory production and the anatomical structure of olfactory bulb are briefly introduced, and the research status of olfactory bulb and its model are introduced in detail, and the physiological characteristics and modeling progress of peripheral cells are also introduced. Secondly, the neuron cable model, ion channel dynamics model, synaptic dynamics model and modeling tool software are introduced in detail. Thirdly, the various cell models and the parameters of synaptic models are introduced, and the topology of the network is also introduced. Finally, on the basis of the network model, the role of the pericyclic cells in the platform-phase was preliminarily analyzed. It is found that the peripheral cells of the platform-shaped sphere synchronize with the peak emitter of the mitral cells projected into the same olfactory pellet. The electrophysiological network model of olfactory pellets established in this paper provides a good platform for the theoretical research of olfactory nervous system coding. It lays a good foundation for the further study of olfactory nervous system coding theory.
【學位授予單位】：浙江大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R338

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