本文關(guān)鍵詞：嗅小球電生理網(wǎng)絡(luò)建模及平臺(tái)期型球周圍細(xì)胞功能研究　出處：《浙江大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 嗅小球 網(wǎng)絡(luò)建模 電生理 平臺(tái)期電位 球周圍細(xì)胞

【摘要】：在嗅覺系統(tǒng)中,嗅球是嗅覺信息在大量傳送到各種次級(jí)結(jié)構(gòu)之前的最后處理階段,是對(duì)嗅覺信息進(jìn)行整合和編碼的重要部位,因而對(duì)嗅球電生理的研究是了解嗅覺系統(tǒng)信息編碼機(jī)制的基礎(chǔ)。嗅球上的嗅小球中包含很多對(duì)嗅覺信息輸入執(zhí)行多種、不同操作的復(fù)雜微網(wǎng)絡(luò),在嗅覺信息處理中起著重要的作用。球周圍細(xì)胞是參與嗅小球回路的重要中間神經(jīng)元,它們?cè)谛嵊X信息處理中所起的功能還有待研究。球周圍細(xì)胞存在很多亞類,不同亞類在功能上也存在差異,其中一個(gè)亞類在刺激下發(fā)放平臺(tái)期電位。平臺(tái)期電位型球周圍細(xì)胞具有能夠?qū)⑿岣杏X神經(jīng)元軸突的高頻輸入轉(zhuǎn)化為低頻輸出的特性,很有可能參與了調(diào)控嗅小球活動(dòng)的時(shí)序模式,這類細(xì)胞正逐步引起人們的注意。本論文建立了一個(gè)包含平臺(tái)期型球周圍細(xì)胞、僧帽細(xì)胞及細(xì)胞間突觸聯(lián)結(jié)的嗅小球網(wǎng)絡(luò)模型,為研究嗅小球回路在嗅覺信息編碼中的作用提供研究平臺(tái),并初步分析發(fā)放平臺(tái)期電位的球周圍細(xì)胞在嗅小球網(wǎng)絡(luò)中的作用。 本論文首先簡(jiǎn)要介紹了嗅覺產(chǎn)生機(jī)理與嗅球解剖結(jié)構(gòu),詳細(xì)介紹了嗅小球及其模型研究現(xiàn)狀,并對(duì)球周圍細(xì)胞的生理特性及其建模進(jìn)展進(jìn)行了介紹；其次,詳細(xì)介紹了建立的嗅小球網(wǎng)絡(luò)模型所采用的神經(jīng)元電纜模型、離子通道動(dòng)力學(xué)模型、神經(jīng)突觸動(dòng)力學(xué)模型以及建模工具軟件；再次,介紹了網(wǎng)絡(luò)模型中加入的各類細(xì)胞模型以及各類突觸模型的參數(shù)設(shè)置,并對(duì)網(wǎng)絡(luò)的拓?fù)浣Y(jié)構(gòu)進(jìn)行了介紹；最后,在網(wǎng)絡(luò)模型的基礎(chǔ)上,初步分析研究了平臺(tái)期型球周圍細(xì)胞的作用,發(fā)現(xiàn)平臺(tái)期型球周圍細(xì)胞對(duì)投射到同一個(gè)嗅小球中的僧帽細(xì)胞的峰值發(fā)放同步有作用。 本論文建立的嗅小球電生理網(wǎng)絡(luò)模型為嗅覺神經(jīng)系統(tǒng)編碼的理論研究提供了一個(gè)良好的平臺(tái),同時(shí)本論文的研究結(jié)果,為下一步對(duì)嗅覺神經(jīng)系統(tǒng)編碼理論的深入研究打下了良好的基礎(chǔ)。
[Abstract]:In olfactory system, olfactory bulb is the final processing stage of olfactory information before it is transferred to various secondary structures, and it is an important part of olfactory information integration and coding. Therefore, the study of olfactory bulb electrophysiology is the basis of understanding the olfactory system information coding mechanism. The olfactory bulb on the olfactory bulb contains many complex micronetworks which perform many different operations on olfactory information input. It plays an important role in the processing of olfactory information. Perigloboid cells are important intermediate neurons involved in the loop of olfactory pellets. Their functions in olfactory information processing still need to be studied. There are many subtypes in peribulbar cells, and different subclasses have different functions. One of the subclasses distributes the plateau potential under stimulation. The cells around the globus have the ability to convert the high-frequency inputs of the axons of the olfactory sensory neurons into low-frequency outputs. It is very likely that these cells are involved in the timing pattern of olfactory pellet activity, which is gradually attracting attention. In this paper, we have established a cell that contains the platform-type periglobule. The model of olfactory pellet network with synaptic connection between mitral cells and cells provides a platform for studying the role of olfactory globule loop in olfactory information coding. The role of peripheral cells in the network of olfactory pellets was preliminarily analyzed. In this paper, the mechanism of olfactory production and the anatomical structure of olfactory bulb are briefly introduced, and the research status of olfactory bulb and its model are introduced in detail, and the physiological characteristics and modeling progress of peripheral cells are also introduced. Secondly, the neuron cable model, ion channel dynamics model, synaptic dynamics model and modeling tool software are introduced in detail. Thirdly, the various cell models and the parameters of synaptic models are introduced, and the topology of the network is also introduced. Finally, on the basis of the network model, the role of the pericyclic cells in the platform-phase was preliminarily analyzed. It is found that the peripheral cells of the platform-shaped sphere synchronize with the peak emitter of the mitral cells projected into the same olfactory pellet. The electrophysiological network model of olfactory pellets established in this paper provides a good platform for the theoretical research of olfactory nervous system coding. It lays a good foundation for the further study of olfactory nervous system coding theory.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R338

【參考文獻(xiàn)】

相關(guān)期刊論文 前6條

1 劉峰;葉學(xué)松;沈小妹;夏靈;;嗅球神經(jīng)細(xì)胞網(wǎng)絡(luò)建模及其信息編碼的研究[J];電子學(xué)報(bào);2009年08期

2 應(yīng)楠;田健;喻賽男;周婧;凌樹才;夏靈;葉學(xué)松;;嗅球球周圍細(xì)胞異質(zhì)性及其仿真建模研究進(jìn)展[J];中國科學(xué):生命科學(xué);2012年07期

3 李文琪;范少光;;嗅覺研究進(jìn)展——2004年諾貝爾生理學(xué)或醫(yī)學(xué)獎(jiǎng)獲獎(jiǎng)工作簡(jiǎn)介[J];生理科學(xué)進(jìn)展;2006年01期

4 王建禮,邰發(fā)道,安書成;哺乳動(dòng)物主要嗅覺系統(tǒng)和犁鼻系統(tǒng)信息識(shí)別的編碼模式[J];獸類學(xué)報(bào);2004年04期

5 文傳源，，易正本;人體運(yùn)動(dòng)神經(jīng)信息傳導(dǎo)系統(tǒng)的建模與仿真方法[J];系統(tǒng)仿真學(xué)報(bào);1994年01期

6 陳興明,徐春曉,倪道鳳;人嗅性誘發(fā)電位[J];中華耳鼻咽喉科雜志;2000年01期

相關(guān)碩士學(xué)位論文 前1條

1 沈小妹;嗅球電生理網(wǎng)絡(luò)建模及其信息編碼的研究[D];浙江大學(xué);2008年

本文編號(hào)：1418261