【摘要】： 目的:識別1800MHz電磁輻射對大鼠心肌、皮膚組織氧化應(yīng)激的影響。 方法:采用0.5mW/cm~2和1.0mW/cm~2功率密度的1800MHz電磁輻射連續(xù)暴露雄性SD大鼠21天,每天暴露12小時,分別設(shè)對應(yīng)的虛擬暴露組,然后測定其心肌、皮膚組織中的超氧化物歧化酶、谷胱甘肽過氧化物酶和過氧化氫酶活性,丙二醛含量。 結(jié)果:0.5mW/cm~2組的暴露組和虛擬暴露組心肌組織中超氧化物歧化酶活性分別為(13.71±1.92)和(18.40±3.71),丙二醛含量分別為(1.94±0.59)和(1.27±0.66),谷胱甘肽過氧化物酶活性分別為(173.83±32.54)和(210.62±29.27);過氧化氫酶活性為(1.12±0.25)和(1.58±0.49)。暴露組和虛擬暴露組皮膚組織中超氧化物歧化酶活性分別為(7.17±1.81)和(10.44±3.01),丙二醛含量為(1.62±0.48)和(1.10±0.53),谷胱甘肽過氧化物酶活性為(63.95±16.52)和(70.91±14.51),過氧化氫酶活性為(1.05±0.29)和(1.44±0.41)差異均有統(tǒng)計學(xué)意義(P＜0.05)。 1.0mW/cm~2功率密度的暴露組大鼠心肌、皮膚組織中超氧化物歧化酶、過氧化氫酶和谷胱甘肽過氧化物酶活性及丙二醛含量與虛擬暴露組相比較,差異沒有統(tǒng)計學(xué)意義(P＞0.05)。 結(jié)論:在本次實驗條件下,0.5mW/cm~2的功率密度的1800MHz電磁輻射致使大鼠心肌、皮膚組織中SOD、CAT和GSH-Px的活性降低,MDA的增高,導(dǎo)致機體產(chǎn)生氧化應(yīng)激反應(yīng)。
[Abstract]:Aim: to identify the effects of 1800MHz electromagnetic radiation on oxidative stress in rat heart and skin. Methods: male SD rats were exposed to 1800MHz electromagnetic radiation with 0.5mW/cm~2 and 1.0mW/cm~2 power density for 21 days for 12 hours a day. The corresponding virtual exposure groups were set up, and then the myocardium was measured. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and catalase (catalase) and malondialdehyde (MDA) in skin tissue. Results: the activities of superoxide dismutase (SOD), malondialdehyde (MDA) and malondialdehyde (MDA) were (13.71 鹵1.92) and (18.40 鹵3.71), (1.94 鹵0.59) and (1.27 鹵0.66) in 0.5mW/cm~2 group and virtual exposure group, respectively. Glutathione peroxidase activity was (173.83 鹵32.54) and (210.62 鹵29.27), respectively. The activities of catalase were (1.12 鹵0.25) and (1.58 鹵0.49), respectively. The activities of superoxide dismutase (SOD), malondialdehyde (MDA) and malondialdehyde (MDA) were (7.17 鹵1.81) and (10.44 鹵3.01), (1.62 鹵0.48) and (1.10 鹵0.53), respectively. The glutathione peroxidase activity, catalase activity and catalase activity were (63.95 鹵16.52) and (70.91 鹵14.51), (1.05 鹵0.29) and (1.44 鹵0.41), respectively (P < 0.05). The activities of superoxide dismutase (SOD), catalase (catalase), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) in myocardium and skin of rats exposed to 1.0mW/cm~2 power density were compared with those of virtual exposure group. The difference was not statistically significant (P > 0.05). Conclusion: under the condition of this experiment, the activity of SOD,CAT and GSH-Px in the myocardium and skin tissue of rats were decreased and the increase of MDA was induced by 1800MHz electromagnetic radiation of power density of 0.5mW/cm~2, which resulted in oxidative stress reaction.
【學(xué)位授予單位】：昆明醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2008
【分類號】：R35

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 ;孕媽咪必讀輻射源排行榜[J];醫(yī)藥與保健;2011年08期

2 杜廣勝;文淵;馬業(yè)新;;BALB/c小鼠乳鼠心肌細(xì)胞的原代培養(yǎng)[J];農(nóng)墾醫(yī)學(xué);2011年01期

3 彭勃;林峰;黃雪珊;;缺血預(yù)處理前加用益母草堿對大鼠心肌再灌注損傷的影響[J];心血管病防治知識(學(xué)術(shù)版);2011年03期

4 李遠(yuǎn)發(fā);汪璐;龔平;黎清波;胡敏;嚴(yán)曉紅;;卷柏水煎液對小鼠心肌缺血再灌注損傷的影響[J];武漢大學(xué)學(xué)報(醫(yī)學(xué)版);2011年04期

5 謝奇;沈一嵐;;沙棘油對SO_2染毒運動訓(xùn)練大鼠心肌脂質(zhì)過氧化的影響[J];環(huán)境與健康雜志;2011年03期

6 王源;張廣斌;儲芳;余爭平;;電磁輻射累積暴露對Th1/Th2細(xì)胞因子平衡影響[J];中國公共衛(wèi)生;2011年07期

7 李滾;龐小峰;;電磁場曝露對生物組織電磁特性的影響[J];生物化學(xué)與生物物理進展;2011年07期

8 陳昀，

本文編號：2463324