【摘要】：目的研究遺傳咨詢者染色體多態(tài)性與臨床效應(yīng)之間的關(guān)系。方法將1500例遺傳咨詢者為研究對(duì)象、采用常規(guī)方法進(jìn)行外周血染色體的培養(yǎng)和制備,核型分析法采用G、C顯帶法.針對(duì)咨詢者的具體情況進(jìn)行AZF區(qū)微缺失檢測.觀察分析染色體多態(tài)性與臨床效應(yīng)的關(guān)系。結(jié)果檢出染色體多態(tài)者110例,其中9號(hào)染色體臂間倒位32例.小Y 35例,大Y8例,D、G組短臂增長30例,1號(hào)和9號(hào)以及16號(hào)染色體次縊痕增長5例。結(jié)論染色體多態(tài)與臨床效應(yīng)具有一定的對(duì)應(yīng)關(guān)系,可造成不孕不育和流產(chǎn)以及死胎等生殖異常,在孕前進(jìn)行遺傳咨詢對(duì)優(yōu)生優(yōu)育具有重要的意義。
[Abstract]:Objective to study the relationship between chromosome polymorphism and clinical effects in genetic counselors. Methods 1500 cases of genetic counseling were used to culture and prepare peripheral blood chromosomes by routine methods. G and C banding methods were used for karyotype analysis. According to the specific situation of the counselor, the microdeletion detection in AZF area was carried out. The relationship between chromosome polymorphism and clinical effect was observed and analyzed. Results chromosome polymorphism was detected in 110 cases, including 32 cases of interarm inversion of chromosome 9. There were 35 cases of small Y, 8 cases of large Y, 30 cases of short arm growth, 5 cases of secondary constriction on chromosome 1 and 9, and 5 cases of chromosome 16 in G group. Conclusion there is a corresponding relationship between chromosome polymorphism and clinical effects, which can lead to infertility, abortion and reproductive abnormalities such as stillbirth. Genetic counseling before pregnancy is of great significance to eugeny and fertility. [WT5 "HZ] conclusion [WT5" BZ] [WT5 "BZ]
【作者單位】： 山東省濟(jì)寧市第一人民醫(yī)院檢驗(yàn)醫(yī)學(xué)部;山東省濟(jì)寧市第一人民醫(yī)院;
【分類號(hào)】：R394

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 顏永杉;北京野生褐家鼠染色體C-帶、核仁形成區(qū)活性和染色體多態(tài)性[J];動(dòng)物學(xué)報(bào);1985年04期

2 ;黃牛和豬的染色體多態(tài)性及其遺傳規(guī)律的研究[J];農(nóng)業(yè)科技通訊;1998年01期

3 周憲庭,湯火順,許碧珍,肖桂芳,傅維寧;中國人群染色體Q帶多態(tài)性——漢族和黎族人群的比較[J];中國科學(xué);1981年12期

4 王小榮;鄧劍霞;李津津;;染色體多態(tài)性與臨床效應(yīng)及生殖關(guān)系的探究[J];遺傳;2007年11期

5 王輝;掃描電子顯微鏡(SEM)對(duì)人類染色體多態(tài)性的研究[J];國外醫(yī)學(xué).遺傳學(xué)分冊(cè);1986年04期

6 Goodfellow P ,戴德林;人類Y染色體[J];國外醫(yī)學(xué).遺傳學(xué)分冊(cè);1986年04期

7 楊本海;武其文;賈超;劉濤;彭弋峰;;21號(hào)染色體多態(tài)性一例報(bào)道[J];皖南醫(yī)學(xué)院學(xué)報(bào);2014年03期

8 姜立春,彭正松;B染色體的研究進(jìn)展[J];吉林師范大學(xué)學(xué)報(bào)(自然科學(xué)版);2005年03期

9 牟洪善;王昌留;;B染色體[J];生命科學(xué)儀器;2006年06期

10 李全順 ,昌恩梓 ,郭曉華 ,趙超;關(guān)于雀科四種鳥的核型分析與探討[J];沈陽大學(xué)學(xué)報(bào);1991年04期

相關(guān)會(huì)議論文 前4條

1 劉志婷;王軍榮;;染色體多態(tài)性引起生殖異常49例[A];中國遺傳學(xué)會(huì)“發(fā)育、遺傳和疾病”研討會(huì)論文匯編集[C];2007年

2 紀(jì)東輝;戴美珍;朱敏;;染色體多態(tài)性與臨床效應(yīng)的探討[A];第四屆全國臨床檢驗(yàn)學(xué)術(shù)會(huì)議論文匯編[C];2006年

3 王小榮;鄧劍霞;李津津;;染色體多態(tài)性與臨床效應(yīng)及生殖關(guān)系的探究[A];中國遺傳學(xué)會(huì)“發(fā)育、遺傳和疾病”研討會(huì)論文匯編集[C];2007年

4 任梅宏;張t，

本文編號(hào)：2442023