【摘要】： 目的 結(jié)合醫(yī)學(xué)圖像三維重構(gòu)技術(shù)和計(jì)算流體力學(xué)(CFD)研究方法對(duì)人體胸主動(dòng)脈內(nèi)血液流動(dòng)進(jìn)行三維數(shù)值模擬并獲取相應(yīng)的血流動(dòng)力學(xué)參數(shù),通過(guò)對(duì)不同個(gè)體(包括正常和異�；颊�)胸主動(dòng)脈內(nèi)血液流動(dòng)分析來(lái)探討血流動(dòng)力學(xué)參數(shù)對(duì)主動(dòng)脈脈管疾病如動(dòng)脈粥樣硬化、動(dòng)脈夾層等疾病的影響,為其各種脈管疾病的發(fā)病機(jī)理提供理論依據(jù)以及對(duì)脈管疾病臨床預(yù)防提供幫助。 方法 應(yīng)用醫(yī)學(xué)圖像后處理軟件MIMICS10.01對(duì)臨床通過(guò)增強(qiáng)CT獲得的二維醫(yī)學(xué)圖像數(shù)據(jù)進(jìn)行處理,得到包括升主動(dòng)脈、主動(dòng)脈弓、降主動(dòng)脈及主動(dòng)脈弓上部的頭臂干、左頸總動(dòng)脈和左鎖骨下動(dòng)脈的胸主動(dòng)脈的整體三維重構(gòu)模型。借助軟件ANSYS-CFX對(duì)主動(dòng)脈弓內(nèi)的血液進(jìn)行血流動(dòng)力學(xué)數(shù)值模擬并得到可視化結(jié)果,獲取正常胸主動(dòng)脈弓和患有降主動(dòng)脈夾層疾病胸主動(dòng)脈弓內(nèi)相關(guān)血流動(dòng)力學(xué)的各種參數(shù)。通過(guò)對(duì)比不同個(gè)體主動(dòng)脈弓內(nèi)血流動(dòng)力學(xué)參數(shù)的異同,及正常胸主動(dòng)脈弓和患有降主動(dòng)脈夾層疾病胸主動(dòng)脈弓內(nèi)血流動(dòng)力學(xué)參數(shù)的異同來(lái)討論血流動(dòng)力學(xué)參數(shù)對(duì)脈管疾病的影響。 結(jié)果 通過(guò)三維重構(gòu)方法建立了真實(shí)的人體主動(dòng)脈弓解剖系統(tǒng)三維幾何模型,實(shí)現(xiàn)了基于人體主動(dòng)脈弓真實(shí)解剖模型進(jìn)行的血流動(dòng)力學(xué)數(shù)值模擬分析。通過(guò)應(yīng)用計(jì)算流體力學(xué)方法獲得了主動(dòng)脈弓內(nèi)血流在心動(dòng)周期內(nèi)不同時(shí)刻的壁面壓力、流線分布、壁面切應(yīng)力等血流動(dòng)力學(xué)參數(shù)。并且通過(guò)對(duì)不同個(gè)體的主動(dòng)脈弓內(nèi)的血流動(dòng)力學(xué)參數(shù)的比較分析確定心臟收縮期的血管壁壓力及壓力變化比舒張期更大；在整個(gè)心動(dòng)收縮期,主動(dòng)脈外側(cè)壁的壓力明顯地高于內(nèi)側(cè)壁的壓力；在主動(dòng)脈弓和降主動(dòng)脈連接的彎曲部位處存在明顯的壓力變化；在主動(dòng)脈弓內(nèi)側(cè)壁的壁面剪應(yīng)力比主動(dòng)脈弓外側(cè)壁的壁面剪應(yīng)力具有更大的量值和變化幅度；在心動(dòng)收縮期主動(dòng)脈弓處出現(xiàn)二次流現(xiàn)象,且在心動(dòng)收縮期出現(xiàn)明顯的漩渦現(xiàn)象。 結(jié)論 計(jì)算流體力學(xué)數(shù)值模擬的方法是目前研究脈管疾病血流動(dòng)力學(xué)的一種可靠方法。通過(guò)三維重構(gòu)方法獲得了個(gè)體化仿真的包括主動(dòng)脈弓及分叉的正常胸主動(dòng)脈、患有降主動(dòng)脈夾層的病態(tài)胸主動(dòng)脈的三維模型,并確定相關(guān)關(guān)鍵技術(shù)方法,為進(jìn)一步進(jìn)行血流動(dòng)力學(xué)研究分析確定基礎(chǔ)。通過(guò)模擬對(duì)比分析,明確血管的彎曲及分叉導(dǎo)致局部壓力變化可能與脈管疾病的形成有一定的關(guān)系。
[Abstract]:Objective to simulate the blood flow in human thoracic aorta by 3D reconstruction of medical images and computational fluid dynamics (CFD) and to obtain the corresponding hemodynamic parameters. The effects of hemodynamic parameters on aortic vascular diseases such as atherosclerosis, dissection and other diseases were investigated by analyzing the blood flow in thoracic aorta of different individuals (including normal and abnormal patients). To provide theoretical basis for the pathogenesis of various vascular diseases and to provide help for clinical prevention of vascular diseases. Methods Medical image post-processing software (MIMICS10.01) was used to process the two-dimensional medical image data obtained by enhanced CT. The ascending aorta, aortic arch, descending aorta and upper arm trunk of aortic arch were obtained, which included ascending aorta, aortic arch, descending aorta and upper part of aortic arch. Three-dimensional reconstruction model of thoracic aorta of left common carotid artery and left subclavian artery. The hemodynamic parameters of the normal aortic arch and the aortic arch with descending aortic dissection were obtained by using the software ANSYS-CFX to simulate the hemodynamics of the blood in the aortic arch and obtain the visual results. By comparing the hemodynamic parameters of different individuals in the aortic arch, The influence of hemodynamic parameters on vascular diseases was discussed by comparing the hemodynamic parameters of thoracic aortic arch with that of normal aortic arch and descending aortic dissection. Results Three-dimensional geometric model of human aortic arch anatomy system was established by three-dimensional reconstruction method, and hemodynamic numerical simulation analysis based on real anatomy model of human aortic arch was realized. The wall pressure, streamline distribution, wall shear stress and other hemodynamic parameters of the aortic arch blood flow at different times in the cardiac cycle were obtained by using computational fluid dynamics (CFD). By comparing and analyzing the hemodynamic parameters of different individuals in aortic arch, it was found that the changes of vessel wall pressure and pressure in systolic period were greater than that in diastolic phase. The pressure on the lateral wall of the aorta was significantly higher than that on the medial wall during the whole systolic period, and there was a significant change in the pressure at the bend of the aortic arch and descending aorta junction. The wall shear stress of the medial wall of the aortic arch is larger than that of the lateral wall of the aortic arch, and the secondary flow occurs at the aortic arch during the systolic period, and the vortex phenomenon appears during the contraction phase of the aortic arch, and the wall shear stress of the inner wall of the aortic arch is larger than the wall shear stress of the lateral wall of the aortic arch. Conclusion Computational fluid dynamics numerical simulation is a reliable method to study hemodynamics of vascular diseases. The three-dimensional model of the normal thoracic aorta with aortic arch and bifurcation and the diseased thoracic aorta with descending aortic dissection were obtained by three-dimensional reconstruction method, and the relevant key techniques were determined. To determine the basis for further hemodynamic analysis. By simulation and contrast analysis, it is clear that the variation of local pressure caused by the bending and bifurcation of blood vessels may be related to the formation of vascular diseases.
【學(xué)位授予單位】：中國(guó)醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R312

【引證文獻(xiàn)】

相關(guān)博士學(xué)位論文 前1條

1 肖漢光;心血管系統(tǒng)的電網(wǎng)絡(luò)建模及動(dòng)脈硬化與狹窄診斷研究[D];重慶大學(xué);2012年

相關(guān)碩士學(xué)位論文 前2條

1 初博;搭橋術(shù)治療DeBakey Ⅲ型主動(dòng)脈夾層的流固耦合數(shù)值模擬研究[D];北京工業(yè)大學(xué);2011年

2 趙璐;不銹鋼冠脈支架結(jié)構(gòu)設(shè)計(jì)及動(dòng)態(tài)應(yīng)力數(shù)值模擬[D];哈爾濱工程大學(xué);2012年

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本文編號(hào)：2367692