【摘要】： 研究目的:通過對產(chǎn)后大鼠存在的氣血虧虛、血瘀狀態(tài)進行研究,論證此狀態(tài)對機體生理、免疫等方面的影響,以論證中醫(yī)關(guān)于“產(chǎn)后多虛多瘀”的理論,指導(dǎo)產(chǎn)褥期康復(fù)保健、預(yù)防產(chǎn)后病的發(fā)生,為產(chǎn)后病的臨床研究和中藥新藥研究提供理想的動物模型。 研究方法:將產(chǎn)后大鼠以游泳加放血方式制成“產(chǎn)后多虛多瘀”模型,與未孕正常組(正常組)、正常產(chǎn)后對照組(產(chǎn)后組)對照,檢測產(chǎn)后第1天和第15天血常規(guī)、血流變的變化;各組大鼠外觀表征的變化;肝臟、胸腺臟器系數(shù)。 研究結(jié)果:1.大鼠產(chǎn)后第一天,紅細胞、血紅蛋白量、紅細胞壓積明顯低于正常組(P＜0.01);第十五天,模型組RBC、HGB、HCT水平繼續(xù)下降,與正常組及對照組比較有顯著差異(P＜0.01),產(chǎn)后組已恢復(fù)到正常水平,與正常組無顯著差異(P＞0.05)。2.模型組大鼠肝臟臟器系數(shù)明顯升高,胸腺系數(shù)明顯降低,與正常組比較有顯著差異(P＜0.05)。3.大鼠產(chǎn)后存在氣虛、血虛、血瘀的外觀表征,模型組隨著實驗的進行,癥狀日漸明顯,而產(chǎn)后組癥狀逐漸消退。 結(jié)論:此種方法造模,在一定程度上可以模擬人體“產(chǎn)后多虛多瘀”的病理生理狀態(tài),可為產(chǎn)后病的研究提供良好動物模型。
[Abstract]:Objective: to study the state of deficiency of qi and blood stasis in postpartum rats, and to demonstrate the effect of this state on body physiology and immunity, so as to demonstrate the theory of "more deficiency and more blood stasis after delivery" in traditional Chinese medicine. To guide the puerperium rehabilitation and health care, to prevent postpartum disease, and to provide an ideal animal model for the clinical study of postpartum disease and the study of new drugs of traditional Chinese medicine. Methods: the postpartum rats were made into the model of "more deficiency and more blood stasis" by swimming and bleeding. The blood routine was detected on the 1st and 15th day of postpartum compared with normal group (normal group) and normal postpartum control group (postpartum group). Changes of hemorheology; changes in appearance of rats in each group; coefficient of liver and thymus organs. The result of the study was: 1. On the first day of postpartum, the contents of erythrocytes, hemoglobin, hematocrit in the model group were significantly lower than those in the normal group (P < 0. 01), and the level of RBC,HGB,HCT in the model group continued to decrease on the 15th day. There was significant difference between postpartum group and normal group (P < 0.01), but there was no significant difference between postpartum group and normal group (P > 0.05) .2. The liver organ coefficient and thymus coefficient in the model group were significantly higher than those in the normal group (P < 0.05) .3.The thymus coefficient of the model group was significantly lower than that of the normal group (P < 0.05). There were signs of deficiency of qi and blood stasis in postpartum rats. The symptoms of the model group became more and more obvious with the experiment, while the symptoms of the postpartum group gradually subsided. Conclusion: this method can simulate the pathophysiological state of postpartum "more deficiency and more blood stasis" to some extent, and can provide a good animal model for the study of postpartum disease.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2008
【分類號】：R-332;R271

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