【摘要】： 目的頸椎后凸畸形模型的構(gòu)建及其相關(guān)研究。方法采用椎板切除等方法構(gòu)建頸椎后凸畸形的動物模型,對模型行生物力學(xué)、影像學(xué)測量、超微結(jié)構(gòu)觀察研究,同時對頸椎后凸畸形的患者行影像學(xué)測量和臨床研究。結(jié)果1實驗組在4～6月后形成了后凸畸形。2后凸節(jié)段多發(fā)生在C2—C5節(jié)段;后凸畸形節(jié)段屈伸運動范圍明顯減小。3實驗組羊的ROM明顯小于正常組,彎曲剛度明顯大于正常組。4實驗羊頸椎軟骨終板有明顯細胞和基質(zhì)受損現(xiàn)象。5提供頸椎體在失狀狀面上的空間位置的數(shù)據(jù);C/M比值評價脊髓受壓明顯優(yōu)于C/F比值;頸椎后凸畸形畸形程度、脊髓壓迫程度和臨床表現(xiàn)有明顯的相關(guān)性。6總結(jié)頸椎后凸畸形特有的臨床特征,制定出個性化的治療方案,患者取得了較好的療效。結(jié)論1成功構(gòu)建出頸椎后凸畸形的動物模型,提供一有效的研究載體。2頸椎后凸畸形的后凸節(jié)段僵硬,后凸節(jié)段多集中在C2—5節(jié)段。3后凸畸形頸椎的ROM的減小,彎曲剛度增加和關(guān)節(jié)面不平整。4頸椎后凸畸形椎體的軟骨終板生長受到抑制,頸椎前部短縮。5為頸椎后凸畸形矯正提供椎體正常空間位置數(shù)據(jù);C/M比值是臨床評估頸脊髓疾病的良好標準之一;當(dāng)后凸節(jié)段后切線夾角為20°和C/M比值小于0.338時出現(xiàn)臨床癥狀,需治療干預(yù)。6頸椎后凸畸形患者有其特有的臨床特征,對于每一位患者要制定出個性化的治療策略。
[Abstract]:Objective to construct a cervical kyphosis model and its related research. Methods the animal model of cervical kyphosis was established by laminectomy. Biomechanics, imaging measurement, ultrastructure observation were performed on the model, and the imaging and clinical studies were performed on the patients with cervical kyphosis. Results 1 from 4 to 6 months after the formation of kyphosis in experimental group, 2 kyphosis segment occurred mostly in C2-C5 segment, and the range of flexion and extension of kyphosis segment in experimental group was significantly smaller than that in normal group, and the range of flexion and extension of kyphosis segment in experimental group was obviously smaller than that in normal group. The bending stiffness was significantly higher than that in the normal group (group .4). The damage of cervical cartilage endplate cells and matrix provided data on the spatial position of cervical vertebrae on the lost plane. The ratio of C / M to C / M was superior to that of C / F ratio in evaluating spinal cord compression. The degree of cervical kyphosis, the degree of spinal cord compression and the clinical manifestation were significantly correlated. 6. The clinical features of cervical kyphosis were summarized, and the individualized treatment scheme was worked out. Conclusion 1 the animal model of cervical kyphosis was successfully constructed, which provided an effective research carrier for the kyphosis segment stiffness of cervical kyphosis. The kyphosis segment was mostly concentrated on the reduction of ROM in C2-5 segment .3 kyphosis. Increased bending stiffness and uneven articular facet. 4 the growth of cartilage endplate in cervical kyphosis was inhibited. The C / M ratio is one of the good criteria for the clinical evaluation of cervical spinal cord diseases, when the angle of the posterior tangent of the kyphosis segment is 20 擄and the ratio of C / M is less than 0.338, the clinical symptoms appear. The patients with cervical kyphosis need treatment and intervention.
【學(xué)位授予單位】：第二軍醫(yī)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2008
【分類號】：R682;R-332

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