本文選題：胃電圖 + 胃電活動(dòng)�。� 參考：《揚(yáng)州大學(xué)》2010年碩士論文

【摘要】： 胃的電機(jī)械活動(dòng)是胃完成其正常生理功能的基礎(chǔ)。多年來(lái)對(duì)胃的電機(jī)械活動(dòng)的研究、建模和仿真已經(jīng)有很多結(jié)果,但是,我們還沒(méi)有看到胃電機(jī)械活動(dòng)傳播的模型及其三維動(dòng)態(tài)模擬的相關(guān)報(bào)道。本論文的主要工作是分析胃電活動(dòng)模型,建立胃電活動(dòng)傳導(dǎo)和蠕動(dòng)收縮傳播的三維模型,進(jìn)而對(duì)其進(jìn)行三維動(dòng)態(tài)模擬。 在闡述胃電機(jī)械活動(dòng)的產(chǎn)生、特點(diǎn)及功能的基礎(chǔ)上,本文首先用Matlab對(duì)離子機(jī)制的電活動(dòng)模型進(jìn)行分析和模擬,總結(jié)出不同類型細(xì)胞電活動(dòng)的規(guī)律和特性,然后研究和模擬了電活動(dòng)傳導(dǎo)模型,最后建立了胃電機(jī)械活動(dòng)關(guān)系和傳播模型,并成功實(shí)現(xiàn)了用Matlab對(duì)胃的電機(jī)械活動(dòng)的三維動(dòng)態(tài)模擬。本文著重論述了逼近真實(shí)胃形態(tài)的三維胃模型和胃電機(jī)械活動(dòng)耦合傳播模型的建立及其Matlab模擬。 本文用Matlab對(duì)傳統(tǒng)離子機(jī)制的電活動(dòng)模型H-H模型和FHN模型進(jìn)行數(shù)學(xué)分析,并用圖象來(lái)展示其電活動(dòng)規(guī)律,通過(guò)比較和分析,總結(jié)出ICC細(xì)胞和平滑肌細(xì)胞之間不同的電活動(dòng)規(guī)律和特性。分析模擬的結(jié)果不僅增進(jìn)了我們對(duì)ICC細(xì)胞和平滑肌細(xì)胞功能作用的理解和認(rèn)識(shí),而且證明了這些胃電模型的合理性。 本文對(duì)較成功的胃電活動(dòng)傳導(dǎo)的錐形體模型和柱導(dǎo)體模型進(jìn)行研究,分析了電活動(dòng)傳導(dǎo)的規(guī)律。本文用這些模型建立的方法和原則建立了新的漿膜慢波傳導(dǎo)模型,并用Matlab進(jìn)行仿真。仿真結(jié)果反應(yīng)了胃電活動(dòng)傳播規(guī)律,證實(shí)了傳導(dǎo)模型的可靠性。 本文首次實(shí)現(xiàn)了用Matlab建立和模擬了接近真實(shí)胃形態(tài)的三維胃模型。為了實(shí)現(xiàn)三維胃模型盡可能接近真實(shí)胃形態(tài),我們用多個(gè)變形錐形體(或者柱形體)組合逼近靜態(tài)胃形態(tài),從而建立了靜態(tài)胃的三維模型。我們?cè)敿?xì)闡述了三維胃模型建立的方法、原則,給出了用Matlab對(duì)其實(shí)現(xiàn)仿真的程序和仿真結(jié)果。 本文首次對(duì)胃的電機(jī)械活動(dòng)建立量化模型,并首次成功地實(shí)現(xiàn)了用Matlab對(duì)胃電機(jī)械活動(dòng)的三維動(dòng)態(tài)模擬。在所建立的三維胃模型基礎(chǔ)上,根據(jù)實(shí)際胃生理,我們建立了胃電活動(dòng)和蠕動(dòng)收縮之間的量化關(guān)系模型,再由電機(jī)械耦合傳導(dǎo)規(guī)律,進(jìn)一步建立了胃電機(jī)械活動(dòng)傳導(dǎo)模型。最后用Matlab分別對(duì)靜息胃的電活動(dòng)傳播和蠕動(dòng)收縮胃的電機(jī)械活動(dòng)的傳播進(jìn)行三維動(dòng)態(tài)模擬,給出了相應(yīng)的模擬結(jié)果。通過(guò)胃電機(jī)械活動(dòng)的三維建模和三維動(dòng)態(tài)模擬,形象地展現(xiàn)了胃電活動(dòng)傳播和胃蠕動(dòng)收縮過(guò)程,為胃的電機(jī)械活動(dòng)提供了三維動(dòng)態(tài)模擬方法和新的認(rèn)知途徑。 總之,我們的研究工作不僅增進(jìn)了對(duì)胃電生理和胃動(dòng)力的理解,而且通過(guò)對(duì)胃電機(jī)械活動(dòng)三維建模和動(dòng)態(tài)模擬,形象展現(xiàn)了胃電活動(dòng)傳播、胃蠕動(dòng)收縮波的傳播過(guò)程,形象地揭示了胃電活動(dòng)與胃動(dòng)力之間的關(guān)系。特別是為胃電活動(dòng)與胃動(dòng)力的研究和模擬提供新的研究和認(rèn)識(shí)途徑,使其在胃動(dòng)力疾病研究和診斷中發(fā)揮更大的作用。
[Abstract]:The electromechanical activity of the stomach is the basis of its normal physiological function. There have been many results in the research, modeling and simulation of electromechanical activities of stomach for many years. However, we have not seen any reports on the model of electromechanical activity propagation and its three-dimensional dynamic simulation. The main work of this paper is to analyze the model of gastric electrical activity, to establish a three-dimensional model of gastric electrical conduction and peristaltic contraction, and then to simulate it dynamically. On the basis of expounding the generation, characteristics and functions of electromechanical activities of stomach, this paper first analyzes and simulates the electric activity model of ion mechanism with Matlab, and summarizes the laws and characteristics of different types of cell electrical activity. Then the conduction model of electromechanical activity is studied and simulated. Finally, the relationship and propagation model of electromechanical activity of stomach are established, and the three-dimensional dynamic simulation of electromechanical activity of stomach with Matlab is successfully realized. In this paper, the establishment and Matlab simulation of three-dimensional gastric model and coupled transmission model of electromechanical activity are discussed. In this paper, the mathematical analysis of H-H model and FHN model of traditional ion mechanism is carried out with Matlab, and the law of electrical activity is shown by image. Through comparison and analysis, the electric activity of H-H model and FHN model of traditional ion mechanism are compared and analyzed. Different patterns and characteristics of electrical activity between ICC cells and smooth muscle cells were summarized. The simulation results not only enhance our understanding of the function of ICC cells and smooth muscle cells, but also prove the rationality of these models. In this paper, the conical model and the column conductor model of gastric electrical conduction are studied, and the law of electrical conduction is analyzed. In this paper, a new serosal slow wave conduction model is established by using the methods and principles of these models, and the simulation is carried out with Matlab. The simulation results reflect the law of gastric electrical activity propagation and verify the reliability of the conduction model. In this paper, a three-dimensional gastric model is established and simulated by Matlab for the first time. In order to realize the three-dimensional gastric model as close as possible to the real gastric shape, we use several deformable cones (or columns) to approximate the static gastric shape, and establish a three-dimensional model of the static stomach. In this paper, the method and principle of establishing 3D gastric model are described in detail, and the program and result of simulation with Matlab are given. In this paper, a quantitative model of electromechanical activity of the stomach is established for the first time, and the three-dimensional dynamic simulation of the electromechanical activity of the stomach with Matlab is successfully realized for the first time. On the basis of the three-dimensional gastric model and the actual gastric physiology, we established a quantitative model of the relationship between gastric electrical activity and peristaltic contraction, and then further established the electromechanical conduction model of gastric electromechanical activity by electromechanical coupling conduction law. Finally, the electrokinetic propagation of resting stomach and the propagation of electromechanical activity of peristaltic contraction stomach were simulated by Matlab, respectively, and the corresponding simulation results were given. Through three-dimensional modeling and three-dimensional dynamic simulation of gastric electromechanical activity, the process of gastric electrical activity propagation and gastric peristalsis contraction is vividly demonstrated, which provides a three-dimensional dynamic simulation method and a new cognitive approach for gastric electromechanical activity. In a word, our research not only improves the understanding of gastric electrophysiology and gastric motility, but also shows the propagation process of gastric electrical activity and gastric peristaltic contraction wave by three-dimensional modeling and dynamic simulation of gastric electromechanical activity. The relationship between gastric electrical activity and gastric motility was vividly revealed. Especially, it provides a new research and understanding way for the study and simulation of gastric electrical activity and gastric motility, and makes it play a more important role in the study and diagnosis of gastric motility diseases.
【學(xué)位授予單位】：揚(yáng)州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R35

【參考文獻(xiàn)】

相關(guān)期刊論文 前7條

1 龔嚴(yán)冰,高上凱;胃電研究的進(jìn)展及前景[J];北京生物醫(yī)學(xué)工程;2001年03期

2 張凱;姜熙君;陳磊;;體表胃電圖慢波提取方法的比較研究[J];北京生物醫(yī)學(xué)工程;2007年04期

3 史洪濤;陳東風(fēng);;Cajal間質(zhì)細(xì)胞的功能與基礎(chǔ)[J];重慶醫(yī)學(xué);2007年15期

4 張開(kāi)光;胃電圖及其在胃動(dòng)力研究中的應(yīng)用[J];國(guó)外醫(yī)學(xué)(消化系疾病分冊(cè));1995年02期

5 劉理,任惠茹;胃電圖的記錄、分析及其應(yīng)用[J];生物醫(yī)學(xué)工程學(xué)雜志;2003年03期

6 張揚(yáng);韓燕飛;許文燮;;胃腸道平滑肌起搏電流產(chǎn)生機(jī)制的研究進(jìn)展[J];世界華人消化雜志;2007年27期

7 安鵬;范紅;陳艷敏;;胃電圖在消化道疾病中的應(yīng)用[J];云南醫(yī)藥;2007年05期

相關(guān)碩士學(xué)位論文 前2條

1 姜熙君;體表胃電圖的檢測(cè)、處理及胃電慢波傳導(dǎo)的研究[D];揚(yáng)州大學(xué);2007年

2 王偉;白蘿卜粗提物作用于Cajal間質(zhì)細(xì)胞促胃腸動(dòng)力作用的機(jī)制[D];第四軍醫(yī)大學(xué);2008年

，

本文編號(hào)：2094271