本文選題：百事樂(lè)膠囊 + 慢性應(yīng)激性抑郁模型��； 參考：《湖南中醫(yī)藥大學(xué)》2013年碩士論文

【摘要】：目的： 探討百事樂(lè)膠囊對(duì)慢性應(yīng)激性抑郁模型小鼠行為學(xué)及腦中腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)和神經(jīng)生長(zhǎng)因子(NGF)含量的影響。 方法： 64只雄性昆明種小鼠,隨機(jī)分為正常組、模型組、百事樂(lè)膠囊組和氟西汀組。除正常組以外,其他各組小鼠進(jìn)行慢性不可預(yù)見(jiàn)性應(yīng)激造模,共造模21d。每天造模前各組小鼠分別給予相應(yīng)藥物灌胃治療,模型組小鼠以等量蒸餾水灌胃。測(cè)定小鼠體質(zhì)量,通過(guò)敞箱實(shí)驗(yàn)和懸尾不動(dòng)實(shí)驗(yàn)檢測(cè)其行為學(xué)改變,參考試劑盒采用免疫組織化學(xué)法檢測(cè)小鼠海馬BDNF、NGF的含量。 結(jié)果： 模型組小鼠發(fā)生明顯的行為學(xué)變化,水平和垂直活動(dòng)明顯減少,懸尾不動(dòng)時(shí)間明顯延長(zhǎng)；百事樂(lè)膠囊組能顯著增加小鼠體質(zhì)量(P0.05),改善小鼠行為學(xué)指標(biāo)(P0.01),百事樂(lè)膠囊組能提高海馬中BDNF和NGF的含量,與模型組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05)；與氟西汀組相比,百事樂(lè)膠囊組各項(xiàng)指標(biāo)差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論： 百事樂(lè)膠囊能顯著改善慢性應(yīng)激性抑郁模型小鼠的行為學(xué)變化,其作用可能與提高慢性應(yīng)激刺激所致的海馬BDNF、NGF的含量有關(guān)。
[Abstract]:Aim: to investigate the effects of Pepsil capsule on behavior and the contents of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in chronic stress depression model mice. Methods: 64 male Kunming mice were randomly divided into normal group, model group, Pepsil capsule group and fluoxetine group. In addition to the normal group, the other groups of mice were induced by chronic unpredictable stress for 21 days. The mice in each group were treated with the corresponding drugs before making the model every day, and the mice in the model group were fed with the same amount of distilled water. The body mass of mice was measured. The behavioral changes were detected by open box test and suspension immobility test. The content of BDNFN NGF in hippocampus of mice was detected by immunohistochemical method with reference kit. Results: in the model group, the behavioral changes were obvious, the horizontal and vertical activities were decreased obviously, and the immobility time of tail suspension was significantly prolonged. The content of BDNF and NGF in hippocampus of the Pepsil capsule group was significantly higher than that of the model group (P0.05), and that of fluoxetine group was higher than that of fluoxetine group (P0.01). There was no significant difference in the indexes of the Pepsil capsule group (P0.05). Conclusion: Pepsil capsule can significantly improve the behavioral changes of chronic stress depression model mice, and its effect may be related to the increase of BDNF NGF content in hippocampus induced by chronic stress stimulation.
【學(xué)位授予單位】：湖南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類(lèi)號(hào)】：R285.5;R-332;R277.7

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