本文選題：靜磁場　切入點：微循環(huán)　出處：《第四軍醫(yī)大學》2010年碩士論文

【摘要】： 磁場是否能治療疾病?這個古老而又懸而未決的話題一直困擾科學界多年,依然沒有定論;同時,隨著磁療技術(shù)和儀器在臨床上的廣泛應(yīng)用,回答磁場是否會對人體產(chǎn)生不良影響這個問題就顯得非常緊迫。 靜磁場對機體微循環(huán)系統(tǒng)的影響研究作為磁場生物效應(yīng)的一個重要分支,日益受到廣泛重視。根據(jù)對國內(nèi)外文獻的回顧,本文綜述了該領(lǐng)域復(fù)雜的研究現(xiàn)狀,分析了該領(lǐng)域經(jīng)常出現(xiàn)復(fù)雜矛盾和尚不明朗的實驗結(jié)果的潛在原因。通過建立磁場的計算機仿真模型,進一步進行磁場對動物和人體微循環(huán)的影響實驗,采用激光多普勒技術(shù)和連續(xù)小波變換技術(shù)評估了磁場暴露后局部微循環(huán)的指標的改變情況,初步探討了磁場對機體微循環(huán)系統(tǒng)影響的機理,以期對該領(lǐng)域的進一步研究提供新的方向。 主要工作概括如下: 一、首次利用Comsol Multiphysics 3.4軟件系統(tǒng)模擬了釹鐵硼型磁片及磁片組、螺線管型交變電磁場和脈沖電磁場的三維時空分布,很好的彌補了傳統(tǒng)磁場生物效應(yīng)實驗中對電磁場的理論分析不夠直觀和形象的缺點。通過統(tǒng)計和數(shù)值分析方法對仿真結(jié)果與實際測量數(shù)據(jù)進行對比分析,證實模擬結(jié)果精確度高,可以作為對實測結(jié)果和理論分析的很好的補充。在計算精度要求不是很高的情況下,甚至可以代替理論分析進行計算,為一些不規(guī)則復(fù)雜磁場的分布問題提供了很好的解決方案。 二、采用上表面中心強度約為220mT的靜磁場(較小尺寸)對正常小鼠耳廓微循環(huán)進行30min短時暴露,發(fā)現(xiàn)在暴露中期和暴露后期,該尺寸和強度的靜磁場未對小鼠耳廓微循環(huán)的血流量產(chǎn)生明顯影響。關(guān)于該強度和該部位的研究國內(nèi)外未見報道。 三、采用了基于連續(xù)小波頻譜分析的新技術(shù)來評估上表面中心強度約為220mT的靜磁場(較大尺寸)30min短期暴露對正常青年甲襞微循環(huán)系統(tǒng)的影響。結(jié)果發(fā)現(xiàn),在暴露中期,磁場可能會引起血管平滑肌肌源性活動、外周神經(jīng)系統(tǒng)的活動和內(nèi)皮相關(guān)的代謝活動的增強(P0.05),而整體的血流量的均值沒有顯著性變化(P0.05),仍然保持在基值附近。此外,撤掉磁場之后,靜磁場暴露中期出現(xiàn)的血流的節(jié)律變化逐漸消失,說明該強度靜磁場對人體微循環(huán)系統(tǒng)影響的延遲作用并不明顯。首次結(jié)合電磁屏蔽技術(shù)和小波頻譜分析對局部微血流的無創(chuàng)實時監(jiān)控技術(shù)研究磁場對人體微循環(huán)的影響,同時首次通過活體實驗驗證了磁場可能會潛在地影響正常人體的微循環(huán)調(diào)控通路,為該領(lǐng)域的進一步深入研究提供新的評估手段和思路。
[Abstract]:Can magnetic fields cure diseases?This ancient and unresolved topic has been troubling the scientific community for many years and remains inconclusive; at the same time, with the widespread use of magnetic therapy techniques and instruments in the clinic,It is urgent to answer the question of whether magnetic fields have adverse effects on the human body.As an important branch of the biological effect of magnetic field, the effect of static magnetic field on microcirculation system has been paid more and more attention.Based on the review of domestic and foreign literatures, this paper summarizes the current situation of complex research in this field, and analyzes the potential causes of complex contradictions and unclear experimental results in this field.By establishing the computer simulation model of magnetic field, the effect of magnetic field on animal and human microcirculation is further tested. The changes of local microcirculation index after magnetic field exposure are evaluated by laser Doppler technique and continuous wavelet transform technique.The mechanism of the effect of magnetic field on microcirculation system is discussed in order to provide a new direction for further research in this field.The main tasks are summarized as follows:For the first time, Comsol Multiphysics 3.4 software is used to simulate the three-dimensional spatial and temporal distribution of the NdFeB magnets, magnetic disk sets, solenoid alternating electromagnetic fields and pulsed electromagnetic fields for the first time.It makes up for the shortcoming of the theory analysis of electromagnetic field in the traditional experiment of biological effect of magnetic field.The simulation results are compared with the actual measured data by means of statistical and numerical analysis. It is proved that the simulation results are accurate and can be used as a good supplement to the measured results and the theoretical analysis.When the precision is not very high, it can even replace the theoretical analysis and provide a good solution for the distribution of some irregular and complex magnetic fields.Second, 30min exposure to the auricle microcirculation of normal mice was carried out by using a static magnetic field (smaller size) with a central intensity of 220mT on the upper surface. It was found that in the middle and late stages of exposure, the microcirculation of the auricle of normal mice was exposed for a short time.The size and intensity of the static magnetic field did not significantly affect the blood flow of auricle microcirculation in mice.There are no reports about the strength and the site.Thirdly, a new technique based on continuous wavelet spectrum analysis was used to evaluate the effect of the magnetostatic magnetic field (220mT) on the nailfold microcirculation system of the normal young people.It was found that in the middle of exposure, the magnetic field may induce the myogenic activity of vascular smooth muscle.The activity of peripheral nervous system and the enhancement of endothelium-related metabolic activity (P0.05A), while the mean of whole blood flow was not significantly changed (P0.05), and remained near the base value.In addition, after removing the magnetic field, the rhythm of the blood flow in the middle period of the exposure gradually disappeared, indicating that the delayed effect of the intensity of the static magnetic field on the human microcirculation system is not obvious.It is the first time to study the effect of magnetic field on human microcirculation by combining electromagnetic shielding technology and wavelet spectrum analysis to non-invasive real-time monitoring of local micro blood flow.At the same time, the experiment in vivo for the first time proves that the magnetic field may potentially affect the regulation pathway of microcirculation in normal human body, which provides a new evaluation method and thought for further research in this field.
【學位授予單位】：第四軍醫(yī)大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R312

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本文編號：1730566