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  本文關(guān)鍵詞： 胃食管反流 球囊擴(kuò)張 模型 動物 細(xì)胞間隙　出處：《中華胃食管反流病電子雜志》2015年04期 　論文類型：期刊論文

【摘要】：目的通過復(fù)合法,構(gòu)建兼具食管下段抗反流屏障缺陷和胃排空障礙的胃食管反流病(GERD)動物模型。方法選取12只5月齡新西蘭大白兔,隨機(jī)分為兩組(各6只),分別行球囊擴(kuò)張法和復(fù)合法。建模成功后4周處死動物,行食管炎建模效果評價和胃動力學(xué)檢測。結(jié)果 2組動物均未見死亡,全部建模成功。按照組織學(xué)食管炎指數(shù)標(biāo)準(zhǔn),組間食管炎嚴(yán)重程度指數(shù)差異無統(tǒng)計學(xué)意義。食管炎建模后可見明顯細(xì)胞間隙增寬,2組間差異無統(tǒng)計學(xué)意義。應(yīng)用復(fù)合法建模對胃排空產(chǎn)生顯著影響,較球囊擴(kuò)張法胃排空率顯著降低。結(jié)論本研究建立的模型既存在食管下段抗反流屏障缺陷,又存在胃腸動力異常所造成的胃排空延遲,提供了一種滿足臨床治療需要的更理想模型。
[Abstract]:Objective to construct GERD animal model of gastroesophageal reflux disease (GERD) with lower esophageal anti-reflux barrier defect and gastric emptying disorder. Methods Twelve 5-month-old New Zealand white rabbits were selected. The animals were randomly divided into two groups (6 rats in each group) by balloon dilatation method and composite method. The animals were killed 4 weeks after the model was established, and the effects of esophagitis modeling and gastric dynamics were evaluated. Results No death was found in the two groups. All of them were successfully modeled. According to the histologic esophagitis index standard, There was no significant difference in the severity index of esophagitis between the two groups. There was no significant difference between the two groups after modeling esophagitis. The compound method was used to model the gastric emptying. The gastric emptying rate was significantly lower than that of balloon dilatation. Conclusion the model has not only the defect of anti-reflux barrier in lower esophagus, but also the gastric emptying delay caused by abnormal gastrointestinal motility. It provides a more ideal model to meet the needs of clinical treatment.
【作者單位】： 上海長征醫(yī)院普外三科;
【分類號】：R571;R-332

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