本文選題：心肌梗死　切入點(diǎn)：心功能　出處：《廣東醫(yī)學(xué)》2017年S2期

【摘要】：目的探討不同年齡大鼠急性心肌梗死后早期膠原纖維變化與心功能的關(guān)系。方法 SD大鼠共30只,分為幼年組(20~25日齡)、青年組(3~5月齡)和老年組(13~15月齡),每組10只,采用左冠狀動(dòng)脈結(jié)扎法制備急性心肌梗死模型,Visual Sonic小動(dòng)物超聲成像系統(tǒng)測(cè)定術(shù)后1周左室射血分?jǐn)?shù)(LVEF)、左室短軸縮短率(LVFS)和左室舒張/收縮末期內(nèi)徑(LVIDd,LVIDs)。石蠟切片行Masson染色,免疫組織化學(xué)檢測(cè)梗死區(qū)Ⅰ型膠原纖維(COLⅠ)、Ⅲ型膠原纖維(COLⅢ)表達(dá)。結(jié)果隨著年齡增長(zhǎng),梗死區(qū)域COLⅠ、COLⅢ表達(dá)逐漸增多,其間的心肌細(xì)胞逐漸減少;梗死后1周LVEF幼年組(59.63±3.21)%、青年組(41.46±4.16)%和老年組(39.38±2.60)%(P0.01)。結(jié)論急性心肌梗死后早期心功能的降低與梗死區(qū)膠原纖維的增多有關(guān),且年齡越大越顯著。
[Abstract]:Objective to investigate the relationship between the changes of collagen fibers and cardiac function after acute myocardial infarction in rats of different ages. Methods Thirty SD rats were divided into two groups: young group (20 ~ 25 days old) and aged group (n = 13) and aged group (n = 10). Left ventricular ejection fraction (LVVEF), left ventricular short axis shortening rate (LVFSS) and left ventricular diastolic / end-systolic diameter (LVIDdN) were measured by visual Sonic small animal ultrasound imaging system in acute myocardial infarction model by left coronary artery ligation. Masson staining was performed on paraffin sections. Immunohistochemistry was used to detect the expression of Col 鈪，

本文編號(hào)：1652980