本文選題：CXCL　切入點：IL-　出處：《中國免疫學雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的:探討血清CXCL12和IL-33在急性缺血性腦卒中預后評估中的價值。方法:選取2014年12月至2016年6月到本院就診的急性缺血性腦卒中患者作為病例組(122例),同時選取本院同期健康體檢人群作為正常組(59名),采用ELISA法檢測研究對象入組時血清CXCL12和IL-33的水平。參照mRS評分將患者分為預后良好組(86例)和預后不良組(36例),并通過受試者工作特征曲線(ROC)和曲線下面積(AUC)評價血清CXCL12和IL-33在急性缺血性腦卒中患者預后評估中的作用。結果:急性缺血性腦卒中患者血清CXCL12水平明顯高于對照組[8.0 ng/ml(IQR,6.7-8.9)VS 3.0 ng/ml(IQR,2.3-3.8),P0.001],IL-33水平明顯高于對照組[65.25 ng/L(IQR,56.05-71.08)VS 35.30 ng/L(IQR,26.73-42.55),P0.001];急性缺血性腦卒中預后良好組患者血清CXCL12水平明顯低于預后不良組[7.4 ng/ml(IQR,6.3-8.3)VS 9.3 ng/m L(IQR,8.3-11.1),P0.001],預后良好組患者IL-33水平明顯高于預后不良組[66.81 ng/L(IQR,61.12-73.29)VS.55.38ng/L(IQR,46.75-64.71),P0.001]。經Pearson相關性分析顯示血清CXCL12和IL-33水平與mRS評分分別呈正相關和負相關(r=0.524,P0.001;r=-0.443,P0.001)。血清CXCL12、IL-33評估急性缺血性腦卒中預后的曲線下面積分別為0.835、0.784,靈敏度分別為77.8%、83.4%,特異度分別為73.3%、66.7%。結論:血清CXCL12和IL-33可能作為急性缺血性腦卒中患者預后評估的標志物。
[Abstract]:Objective: to evaluate the prognostic value of serum CXCL12 and IL-33 in patients with acute ischemic stroke. Methods: 122 patients with acute ischemic stroke from December 2014 to June 2016 were selected. The serum levels of CXCL12 and IL-33 were measured by ELISA method in 59 normal controls. According to mRS score, the patients were divided into good prognosis group (86 cases) and poor prognosis group (36 cases). The role of serum CXCL12 and IL-33 in evaluating the prognosis of patients with acute ischemic stroke was evaluated. Results: the level of serum CXCL12 in patients with acute ischemic stroke was significantly higher than that in the control group [8.0]. The levels of IL-33 in IQR 6.7-8.9 vs 3.0 ng / ml IQR 2.3-3.8P0.001 were significantly higher than those in the control group [56.05-71.08VS 35.73-42.55P0.001]; the serum CXCL12 level in patients with good prognosis of acute ischemic stroke was significantly lower than that in patients with poor prognosis [7.4ngml / ml IQR6.3-8.3VS 9.3 ng/m IQR (8.3-11.1ng / P0.001)], and the IL-33 level in good prognosis group was significantly higher than that in poor prognosis group (66.81% vs 8.3-8.3VS 9.3 ng/m P0.001). Pearson correlation analysis showed that the serum CXCL12 and IL-33 levels were positively and negatively correlated with the mRS score, respectively. The area under the curve of serum CXCL12IL-33 for evaluating the prognosis of acute ischemic stroke was 0.835 鹵0.784, and the sensitivity was 77.80.34, respectively. Conclusion: serum CXCL12 and IL-33 may be used as prognostic markers in patients with acute ischemic stroke.
【作者單位】： 南開大學附屬醫(yī)院(天津市第四醫(yī)院)神經內科;
【分類號】：R743.3
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本文編號：1568637