本文關(guān)鍵詞： 糖尿病酮癥酸中毒 血淀粉酶 急性胰腺炎 甘油三酯　出處：《中國(guó)糖尿病雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的探討DKA患者血淀粉酶(AMS)升高的臨床危險(xiǎn)因素。方法選取263例DKA患者為研究對(duì)象,根據(jù)AMS水平分為正常組(DKA,n=188)和升高組(HAMS,n=75),HAMS組根據(jù)有無(wú)急性胰腺炎(AP)發(fā)生分出HAMS合并AP亞組(HAMS+AP,n=25),檢測(cè)FPG、TG、AMS等指標(biāo)。結(jié)果 HAMS組AMS升高發(fā)生率28.5%,AP發(fā)生率9.5%,其TG、FPG、HbA_1c、Na~+、血漿滲透壓、BUN、Scr水平均高于DKA組(P0.05或P0.01);HAMS+AP亞組TG、FPG、血漿滲透壓、BUN、CO_2結(jié)合力(CO_2CP)恢復(fù)正常時(shí)間均高于HAMS組(P0.05或P0.01)。相關(guān)分析顯示,AMS升高與TG、FPG、Na~+、血漿滲透壓、BUN均呈正相關(guān)(r=0.146、0.133、0.126、0.182、0.192,P0.05或P0.01)。Logistic二元回歸分析顯示,TG升高是DKA患者AMS升高的獨(dú)立危險(xiǎn)因素(OR1.244,P0.01),是HAMS+AP的獨(dú)立危險(xiǎn)因素(OR 1.211,P0.05)。結(jié)論 TG升高是DKA患者AMS升高的臨床相關(guān)危險(xiǎn)因素,亦是誘發(fā)AP的危險(xiǎn)因素。本研究為DKA患者早期篩查AP提供了一定的理論依據(jù)。
[Abstract]:Objective to investigate the clinical risk factors of elevated serum amylase in patients with DKA. Methods 263 patients with DKA were selected as subjects. According to the level of AMS, the patients were divided into two groups: normal group (DKA, 1888) and elevated group, according to the occurrence of acute pancreatitis (AP), HAMS combined with AP subgroup was divided into two groups. Results the incidence of AMS in HAMS group was 9.5AP, and the incidence of AMS in HAMS group was 9.5AP, and the incidence of AMS in HAMS group was 9.5. the incidence of AMS in HAMS group was 9.5AP, and the incidence of AMS was 9.5in HAMS group. The plasma osmotic pressure (BUNC) SCR level was higher than that in DKA group (P 0.05 or P 0.01), and the recovery time of plasma osmotic pressure (P < 0.05) was higher than that of HAMS group (P 0.05 or P 0.01). The correlation analysis showed that the increase of plasma osmotic pressure was associated with TGFP GG Na ~, and the recovery time of plasma osmotic pressure was significantly higher than that of HAMS group (P 0.05 or P 0.01). Plasma osmotic pressure (bun) was positively correlated with 0.146U 0.133U 0.126U 0.182U 0.192 (P0.05) or P0.01n.Logistic regression analysis showed that the increase of TG was an independent risk factor for the elevation of AMS in patients with DKA and was an independent risk factor for HAMS AP (OR 1.211P0.050.Conclusion the increase of TG is a clinical risk factor for the increase of AMS in DKA patients. This study provides a theoretical basis for early screening of AP in patients with DKA.
【作者單位】： 南京醫(yī)科大學(xué)附屬淮安第一醫(yī)院急診科;南京醫(yī)科大學(xué)附屬淮安第一醫(yī)院內(nèi)分泌科;
【分類號(hào)】：R587.2

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