本文關(guān)鍵詞： 丹參多酚酸鹽 急性腦缺血　出處：《實用藥物與臨床》2013年02期 　論文類型：期刊論文

【摘要】：目的探討丹參多酚酸鹽治療急性腦缺血患者的臨床療效。方法將96例急性腦缺血患者隨機分為治療1組、治療2組、對照組,各32例,對照組采用常規(guī)治療:抗血小板、腦保護劑及改善腦循環(huán)、血壓控制等;治療1組在常規(guī)治療的基礎(chǔ)上加用丹參多酚酸鹽100 mg/d靜脈滴注,共治療14 d;治療2組在常規(guī)治療的基礎(chǔ)上加用丹參多酚酸鹽200 mg/d靜脈滴注,共治療14 d。測定治療前后三組患者的神經(jīng)功能缺失評分(NDS)和日常生活活動能力評分(ADL)。結(jié)果治療1組治療前后NDS為(21.65±3.75)、(17.75±2.74)分,治療2組為(21.28±4.08)、(15.43±3.057)分,對照組為(21.50±3.66)、(18.53±3.63)分,三組NDS均降低(P0.05),且治療2組改善情況優(yōu)于對照組(P0.05)。治療1組治療前后ADL評分分別為(24.21±3.12)、(58.23±5.31)分,治療2組為(28.25±4.82)、(59.23±8.54)分,對照組為(29.53±4.51)、(55.78±8.55)分。三組治療后ADL評分明顯升高,但治療2組較對照組升高明顯(P0.05)。治療2組總有效率(90.62%)高于對照組(68.75%)(P0.05)。結(jié)論中劑量丹參多酚酸鹽可顯著改善急性腦缺血患者的病情,值得臨床推廣。
[Abstract]:Objective to investigate the clinical efficacy of salvia miltiorrhiza polyphenolic acid in the treatment of acute cerebral ischemia. Methods 96 patients with acute cerebral ischemia were randomly divided into treatment group (n = 32), treatment group (n = 32) and control group (n = 32). The control group was treated with routine treatment: antiplatelet, cerebral protectant, improving cerebral circulation, blood pressure control, etc. Group 1 was treated with salvia miltiorrhiza polyphenolic acid 100 mg/d intravenous drip on the basis of routine treatment for 14 days. Group 2 was treated with salvia miltiorrhiza polyphenolic acid for 200 mg/d on the basis of routine treatment. After 14 days of treatment, the neurological deficit scores and ADL scores of the three groups were measured before and after treatment. Results the NDS of group 1 before and after treatment were (. 21.65 鹵3.75). The scores were 17.75 鹵2.74, 21.28 鹵4.08, 15.43 鹵3.057 in the treatment group and 21.50 鹵3.66 in the control group. The NDS of the three groups was decreased by 18.53 鹵3.63 (P 0.05). The improvement of the treatment group was better than that of the control group (P 0.05). The ADL score before and after treatment in the treatment group was 24.21 鹵3.12 and 58.23 鹵5.31, respectively. 59.23 鹵8.54 in the treatment group and 29.53 鹵4.51 in the control group. The score of ADL in the three groups was significantly higher after treatment than that in the control group (55.78 鹵8.55). However, the total effective rate of treatment group 2 was significantly higher than that of control group (P 0.05), and the total effective rate of treatment group 2 was higher than that of control group (P 0.05). Conclusion moderate dose salvia miltiorrhiza polyphenolic acid can significantly improve the condition of patients with acute cerebral ischemia. It is worth popularizing in clinic.
【作者單位】： 上海交通大學(xué)附屬新華醫(yī)院老年科;
【分類號】：R743.3
【正文快照】： 急性缺血性腦血管病是中老年患者的常見疾病,發(fā)病后引起神經(jīng)元及神經(jīng)膠質(zhì)變性,腦實質(zhì)軟化、壞死,從而引起神經(jīng)功能缺損,目前其發(fā)病率有逐年增加的趨勢,致死率及致殘率較高,嚴重影響患者的生活質(zhì)量及預(yù)后。注射用丹參多酚酸鹽是從單味中藥丹參中提取所得,用于心絞痛患者已取得

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