發(fā)布時(shí)間：2018-01-21 17:27

  本文關(guān)鍵詞： 阿替普酶 拜阿司匹林 急性腦梗死 靜脈溶栓　出處：《天津醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：觀察阿替普酶治療急性腦梗死的臨床療效和安全性。 方法：2011年6月—2013年6月在天津市環(huán)湖醫(yī)院住院的急性腦梗死患者80例隨機(jī)分為治療組(40例)和對照組(40例)。治療組給予阿替普酶0.9mg/kg用量,總劑量的10%靜脈推注,剩余劑量在隨后60min內(nèi)持續(xù)靜脈滴注,24h后經(jīng)頭顱CT證實(shí)患者有無出血。在兩組患者治療前、治療后1、3、7、30、90d進(jìn)行歐洲卒中神經(jīng)功能缺損程度(ESS)評分和Barthel指數(shù)評分。 結(jié)果：兩組治療后患者神經(jīng)功能均得到不同程度的改善,和治療前相比,兩組患者治療后3、7、30、90d的ESS平均值均較治療前有顯著提高,治療前后差異有統(tǒng)計(jì)學(xué)意義(P0.05)；治療后,治療組較對照組升高更明顯,兩組差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組治療后Barthel指數(shù)較治療前均明顯提高,治療前后差異有統(tǒng)計(jì)學(xué)意義(P0.05)；治療1d后兩組Barthel指數(shù)差異無統(tǒng)計(jì)學(xué)意義,但治療3、7、30、90d后治療組Barthel指數(shù)平均值明顯高于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：阿替普酶治療急性腦梗死能夠顯著改善進(jìn)展性腦梗死患者的神經(jīng)功能缺損癥狀,提高日常生活活動能力,療效顯著。
[Abstract]:Objective: to observe the clinical efficacy and safety of atropase in the treatment of acute cerebral infarction. Methods: from June 2011 to June 2013, 80 patients with acute cerebral infarction were randomly divided into treatment group (n = 40) and control group (n = 40). In the treatment group, the dosage of atropase was 0.9mg / kg. 10% of the total dose was injected intravenously, and the remaining dose was continuously infused within 60 minutes after 24 hours of continuous intravenous drip. After 24 hours of continuous intravenous drip, the patients were confirmed by cranial CT to be haemorrhagic or not. European neurologic deficit scale (ESS) and Barthel index were evaluated at 30 d and 90 d. Results: the neurological function of the patients in the two groups were improved in different degrees after treatment. Compared with before treatment, the average ESS of the patients in the two groups was significantly higher than that before treatment. The difference before and after treatment was statistically significant (P 0.05). After treatment, the treatment group than the control group increased significantly, the difference between the two groups was statistically significant (P 0.05). The two groups after treatment Barthel index was significantly higher than before treatment. The difference before and after treatment was statistically significant (P 0.05). There was no significant difference in Barthel index between the two groups after one day of treatment, but the average Barthel index of the treatment group was significantly higher than that of the control group after 30 days of treatment. The difference was statistically significant (P 0.05). Conclusion: the treatment of acute cerebral infarction with atropase can significantly improve the neurological deficit symptoms of patients with progressive cerebral infarction, improve the ability of daily life, and the curative effect is remarkable.
【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743.3

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