【摘要】：目的: 評價犬胸主動脈內(nèi)國產(chǎn)分體式覆膜支架置入術(shù)的技術(shù)可行性與生物相容性。 材料和方法: 成年雜種犬12只,隨機(jī)分為3組,每組4只。右側(cè)股動脈切開,將國產(chǎn)分體式主動脈覆膜支架置于犬胸主動脈內(nèi),且使外層移植物的近端至少接近左鎖骨下動脈開口的遠(yuǎn)端,觀察支架釋放的技術(shù)可行性。按照實驗分組分別于術(shù)后4周、8周、12周血管造影復(fù)查分體式覆膜支架在犬胸主動脈內(nèi)情況,后處死實驗犬獲取標(biāo)本,大體觀察及HE染色顯微鏡下觀察支架與血管壁貼合情況、支架內(nèi)表面內(nèi)膜化情況、血管壁病理變化等。 結(jié)果: 10只犬成功經(jīng)右側(cè)股動脈將國產(chǎn)分體式主動脈覆膜支架置于犬胸主動脈內(nèi),無需降壓,釋放順利精確,無移位變形;1只犬因內(nèi)支架輸送系統(tǒng)進(jìn)入時右側(cè)股動脈撕裂出血而死亡,1只犬因外層支架移植物向前移位致升主動脈破裂立即死亡。術(shù)后4周、8周、12周血管造影復(fù)查示支架位置及開放良好,無移位、變形、裂斷、再狹窄發(fā)生。兩端裸支架4周時完全內(nèi)膜化,支架移植物的內(nèi)表面4周起出現(xiàn)內(nèi)膜化,隨著時間的推移,內(nèi)膜化逐漸明顯,12周時內(nèi)膜基本覆蓋支架移植物。 結(jié)論: 介入經(jīng)犬股動脈置入國產(chǎn)分體式主動脈覆膜支架于胸主動脈內(nèi),技術(shù)上是可行的,并具有良好的生物相容性。
[Abstract]:Objective: to evaluate the technical feasibility and biocompatibility of canine thoracic aortic stent implantation. Materials and methods: 12 adult mongrel dogs were randomly divided into 3 groups with 4 dogs in each group. The right femoral artery was incised and the domestic split aortic stent was placed in the thoracic aorta of the dog and the proximal end of the outer graft was at least close to the distal end of the left subclavian artery opening. The technical feasibility of stent release was observed. After 4 weeks, 8 weeks and 12 weeks after operation, the segmented stent was performed in the thoracic aorta of dogs, and then the dogs were killed to obtain the specimens. Gross observation and HE staining microscope were used to observe the adhesion of stents to vascular wall, the intimation of stent surface and the pathological changes of vascular wall. Results: 10 dogs were successfully placed into the thoracic aorta via the right femoral artery, without any hypotension, accurate release and no displacement. One dog died after the right femoral artery laceration and one dog died of ascending aorta rupture due to the forward displacement of the outer stent graft. Angiographic examination at 4, 8 and 12 weeks postoperatively showed that the stent was well located and open, without displacement, deformation, fracture and restenosis. The endarteal endomativization of the bare stents at both ends was complete at 4 weeks and the inner surface of the stents was intimated at 4 weeks. With the passage of time the intimation became more and more obvious and the intima covered the stents basically at 12 weeks. Conclusion: it is technically feasible and has good biocompatibility for interventional placement of domestic split aortic stent into thoracic aorta through femoral artery.
【學(xué)位授予單位】：南京醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R543;R-332

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