本文選題：百日咳 + 抗體水平�。� 參考：《中國(guó)生物制品學(xué)雜志》2015年12期

【摘要】：目的分析上海市虹口區(qū)青少年人群中百日咳全抗體水平,為人群百日咳免疫策略提供依據(jù)。方法 2010年在上海市虹口區(qū)內(nèi)隨機(jī)選擇6~10歲、11~14歲及15~19歲的健康青少年225人,對(duì)青少年百日咳疫苗免疫史和持續(xù)≥14 d咳嗽史進(jìn)行調(diào)查。采集靜脈血樣,分離血清,用ELISA法檢測(cè)百日咳全抗體Ig G。結(jié)果實(shí)際納入研究的對(duì)象共214人,百日咳疫苗全程接種率為93.93%,持續(xù)2周以上咳嗽患病率為15.42%;青少年人群百日咳全抗體GMT水平為21.88 U/ml,全抗體陽(yáng)性(Ig G≥50 U/ml)率為26.64%,高抗體水平(Ig G≥100 U/ml)陽(yáng)性率為15.42%;各年齡組百日咳全抗體GMT(F=19.90)、抗體陽(yáng)性率(χ2=18.19)和高抗體水平陽(yáng)性率(χ2=9.73)差異均有統(tǒng)計(jì)學(xué)意義(P0.01),隨年齡增長(zhǎng)均呈顯著上升趨勢(shì)(P0.01);1年內(nèi)有持續(xù)2周以上咳嗽史人群百日咳全抗體GMT(t=2.505)、抗體陽(yáng)性率(χ2=7.071)和高抗體水平陽(yáng)性率(χ2=6.626)均明顯高于無(wú)2周以上咳嗽史人群(P均0.05)。結(jié)論虹口區(qū)青少年人群中存在百日咳感染病例被漏診或未發(fā)現(xiàn);現(xiàn)行百日咳疫苗免疫程序?qū)η嗌倌瓴痪哂谐志玫谋Ｗo(hù)作用。為虹口區(qū)青少年人群的百日咳疫苗免疫策略提供科學(xué)依據(jù),有必要進(jìn)一步開(kāi)展醫(yī)院/社區(qū)百日咳病例的前瞻性主動(dòng)監(jiān)測(cè)。
[Abstract]:Objective to analyze the total antibody level of pertussis in the adolescent population of Hongkou District, Shanghai, and to provide evidence for the population's pertussis immunization strategy. Methods 225 healthy adolescents aged 1114 and 1519 were randomly selected from Hongkou District of Shanghai in 2010 to investigate the history of immunization against pertussis vaccine and the history of cough lasting more than 14 days. Venous blood samples were collected and serum samples were isolated. The whole antibody Ig G of pertussis was detected by Elisa. Results A total of 214 subjects were actually included in the study. The total vaccination rate of pertussis vaccine was 93.93%, the prevalence of cough was 15.42%, the GMT level of pertussis total antibody was 21.88 U / ml, the total antibody positive rate (IgG 鈮，

本文編號(hào)：2089760