本文選題：氣虛血瘀 + 宮環(huán)出血病�。� 參考：《湖南中醫(yī)藥大學(xué)》2010年碩士論文

【摘要】： 目的：為了加強(qiáng)對(duì)于氣虛血瘀型宮環(huán)出血病證結(jié)合大鼠模型的研究,從更深層次和角度來研究氣虛血瘀型宮環(huán)出血的特點(diǎn)和病因病機(jī),為本病的治療提供新的治療方法和思路。 方法：將24只SD大鼠分為空白組、置環(huán)組、模型組、治療組4組,每組各6只。對(duì)除空白組外3組置環(huán)后,模型組、治療組采用復(fù)合式造模28天,建立氣虛血瘀型宮環(huán)出血病證結(jié)合大鼠模型。從造模第1天起節(jié)食,強(qiáng)迫游泳,第14天起皮下注射腎上腺激素,治療組第21天起采用宮環(huán)Ⅱ號(hào)方進(jìn)行對(duì)抗治療7天。觀察4組大鼠的一般行為表現(xiàn)及體重變化,子宮組織形態(tài)涂片,分析蛋白質(zhì)芯片各指標(biāo)。 結(jié)果：模型組大鼠出現(xiàn)氣虛、乏力、便溏等表現(xiàn),體重較造模前明顯減輕(P0.01),子宮組織形態(tài)涂片呈現(xiàn)內(nèi)膜上皮細(xì)胞壞死脫落,炎癥細(xì)胞浸潤等。蛋白質(zhì)芯片各指標(biāo)中子宮組織中IFN-γ及IL-4相對(duì)表達(dá)水平模型組較空白組、置環(huán)組均明顯降低(P0.01),治療組較模型組升高(0.01P0.05)；MIP-3α相對(duì)表達(dá)水平模型組較空白組明顯降低(P0.01),與置環(huán)組比較無統(tǒng)計(jì)學(xué)意義(P0.05),治療組較模型組升高(0.01P0.05)；VEGF相對(duì)表達(dá)水平模型組與空白組、置環(huán)組比較無統(tǒng)計(jì)學(xué)意義(P0.05),治療組較模型組降低(0.01P0.05)。余指標(biāo)無統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：對(duì)上環(huán)后大鼠節(jié)食、強(qiáng)迫游泳及皮下注射腎上腺素可導(dǎo)致大鼠一般行為表現(xiàn)及體重變化,子宮組織形態(tài)及子宮組織蛋白質(zhì)芯片各指標(biāo)發(fā)生改變,可證明建立氣虛血瘀型宮環(huán)出血病證結(jié)合大鼠模型成功。
[Abstract]:Objective: in order to strengthen the study on the syndromes of uterine ring hemorrhage of Qi deficiency and blood stasis type combined with rat model, to study the characteristics and etiology and pathogenesis of uterine ring hemorrhage of Qi deficiency and blood stasis type from a deeper level and an angle, and to provide a new treatment method and thought for the treatment of this disease. Methods: 24 SD rats were divided into blank group, ring setting group, model group and treatment group with 6 rats in each group. The model group and treatment group were treated with compound model for 28 days to establish the model of uterine ring hemorrhage syndrome of Qi deficiency and blood stasis combined with rat model. From the first day of the model, forced swimming, subcutaneous injection of adrenal hormone on the 14th day, the treatment group was treated with Gong Huan 鈪，

本文編號(hào)：1947300