本文選題：曲霉 + 耐藥　； 參考：《微生物與感染》2015年02期

【摘要】：隨著抗真菌藥物在臨床上的廣泛使用,致病性真菌的耐藥率越來越高,耐藥曲霉對(duì)侵襲性曲霉病的診治產(chǎn)生了重要影響。目前,致病性曲霉耐藥性的確定主要依靠抗真菌藥敏試驗(yàn)和分子診斷。在有關(guān)曲霉耐藥機(jī)制的研究中,報(bào)道最多的是曲霉對(duì)唑類藥物的耐藥,其機(jī)制主要包括外排泵表達(dá)增加、靶酶Cyp51突變和表達(dá)水平增高、形成生物膜,以及熱休克蛋白90(Hsp90)介導(dǎo)的信號(hào)通路參與而導(dǎo)致的耐藥。本文就上述領(lǐng)域近年來的主要進(jìn)展進(jìn)行綜述。
[Abstract]:With the wide use of antifungal drugs in clinic, the drug resistance rate of pathogenic fungi is higher and higher. The drug resistance of Aspergillus sp. Has played an important role in the diagnosis and treatment of invasive aspergillosis. At present, the determination of drug resistance of Aspergillus mutans mainly depends on antimicrobial susceptibility test and molecular diagnosis. Among the studies on drug resistance of Aspergillus sp., the resistance of Aspergillus to Azoles was reported most frequently. The mechanisms include increased expression of efflux pump, mutation and expression level of target enzyme Cyp51, and formation of biofilm. And heat shock protein 90 (Hsp90)-mediated signal pathway involved in drug resistance. This paper reviews the main progress in the above fields in recent years.
【作者單位】： 北京大學(xué)第一醫(yī)院皮膚性病科;北京大學(xué)真菌與真菌病研究中心皮膚病分子診斷北京市重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金(81471925) 教育部“新世紀(jì)人才支持計(jì)劃”(NCET-10-0198)
【分類號(hào)】：R379

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 李麗娟;陳偉;許輝;萬U，

本文編號(hào)：1850174