天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

雷公藤紅素降低糖尿病小鼠血糖的機制研究

發(fā)布時間:2018-03-27 14:15

  本文選題:雷公藤紅素 切入點:β-胰島細(xì)胞 出處:《湖北工業(yè)大學(xué)》2013年碩士論文


【摘要】:目的:雷公藤紅素(Celastrol)是一種三萜類化合物,最早從南蛇藤莖中分離得到,具有抗炎,抗癌等多種活性,臨床上主要用于治療類風(fēng)濕關(guān)節(jié)炎,皮膚病和腎臟疾病。我們的前期研究表明在適當(dāng)?shù)膭┝肯拢?00μg/kg),雷公藤紅素具有很明顯的降低由鏈脈佐菌素(STZ,50mg/kg)所誘導(dǎo)產(chǎn)生糖尿病小鼠血糖的作用。為了進(jìn)一步探討雷公藤紅素的作用機理,本文通過建立細(xì)胞和動物模型,研究了雷公藤紅素對其功能的影響。 方法:通過炎癥因子(IL-1,IL-6)將β-胰島細(xì)胞(INS-1)感染成炎癥狀態(tài)后,加入雷公藤紅素(100nM-300nM)治療處理,觀察細(xì)胞狀態(tài)(Immunofluorescence technique)的變化,并測定其功能(KSIS),細(xì)胞凋亡水平(FCM)。 建立C57BL/6J小鼠的糖尿病模型,對其體重(BW),隨機血糖(GLU),24小時尿糖(UGE),尿蛋白(UP),腎功能(Renal Function)等指標(biāo)進(jìn)行測定,并提取腎小管上皮細(xì)胞總RNA,檢測鈉葡萄糖共轉(zhuǎn)移蛋白(SGLT)表達(dá)的變化。 結(jié)果:INS-1細(xì)胞通過雷公藤紅素處理24小時之后,與對照組相比,β-胰島細(xì)胞狀態(tài)和功能明顯好轉(zhuǎn),細(xì)胞凋亡得到了抑制。糖尿病小鼠經(jīng)雷公藤紅素治療后,血糖明顯降低,24小時尿糖增多,尿蛋白增加,,腎小球橫截面積增加,SGLT的表達(dá)明顯降低。 結(jié)論:雷公藤紅素對炎癥狀態(tài)下β-胰島細(xì)胞具有一定的保護作用,通過對鈉葡萄糖共轉(zhuǎn)運體的抑制,減少了葡萄糖的重吸收,從而降低糖尿病小鼠的血糖。
[Abstract]:Objective: Tripterygium wilfordii Celastrola is a triterpenoid compound, which was first isolated from the stem of Sagitaria sinensis. It has many anti-inflammatory and anticancer activities, and is mainly used in the treatment of rheumatoid arthritis. Skin diseases and kidney diseases. Our previous studies have shown that tripterygium at an appropriate dose of 500 渭 g / kg, tripteryline can significantly reduce the effect of streptozotocin (STZ) 50 mg / kg on the production of blood glucose in diabetic mice. The mechanism of the action of tripsin, The effects of tripterine on the function of tripterygium wilfordii were studied by establishing cell and animal models. Methods: 尾 -islet cells (INS-1) were infected into inflammatory state by inflammatory cytokine IL-1- (IL-6), then treated with Tripterygium wilfordii 100nM-300nM), the changes of immunofluorescence technique were observed, and the function of KSISI and the level of apoptosis were measured. The diabetic model of C57BL/6J mice was established. The body weight of BWN, 24 hours urine glucose, urine protein, Renal function were measured, and the total RNAs of renal tubular epithelial cells were extracted to detect the expression of sodium and glucose co-transfer protein (SGLTs). Results after treated with tripterine for 24 hours, 尾 -islet cells were significantly improved in state and function, and apoptosis was inhibited after treatment with tripterine in diabetic mice. The expression of SGLT was significantly decreased after 24 hours of blood glucose decreased, urine protein increased and glomerular cross-sectional area increased. Conclusion: Tripterygium wilfordii has a protective effect on 尾 -islet cells in inflammatory state. By inhibiting sodium and glucose co-transporter, tripterygium can reduce the reabsorption of glucose and decrease the blood glucose in diabetic mice.
【學(xué)位授予單位】:湖北工業(yè)大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2013
【分類號】:R-332;R587.1;R965

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 周幽心;姜華;陳學(xué)彬;黃煜倫;陳龍;葉明;;雷公藤紅素對荷SHG44膠質(zhì)瘤裸鼠的抑瘤試驗[J];中國神經(jīng)腫瘤雜志;2005年04期

2 盛輝;李文君;盛春君;秦嶺;王洪復(fù);曲伸;吳國亭;;噻唑烷二酮類降糖藥物與骨質(zhì)疏松癥[J];中華骨質(zhì)疏松和骨礦鹽疾病雜志;2011年02期

3 張富東;李玲;;新型抗2型糖尿病藥物鈉-葡萄糖協(xié)同轉(zhuǎn)運蛋白2抑制劑研究進(jìn)展[J];國際藥學(xué)研究雜志;2011年05期

4 陳國柱;徐元基;杜芝燕;于曉Y

本文編號:1671865


資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/shiyanyixue/1671865.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶5d1c9***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
国产女性精品一区二区三区| 我想看亚洲一级黄色录像| 日本人妻丰满熟妇久久| 成年人视频日本大香蕉久久| 精品一区二区三区免费看| 91麻豆精品欧美视频| 丁香七月啪啪激情综合| 激情视频在线视频在线视频| 好吊视频一区二区在线| 久久久精品日韩欧美丰满| 久久国产亚洲精品赲碰热| 亚洲精品国产主播一区| 国产精品一区二区三区欧美| 国产乱淫av一区二区三区| 亚洲欧美天堂精品在线| 亚洲中文字幕乱码亚洲| 九九九热在线免费视频| 国产色第一区不卡高清| 中文字幕不卡欧美在线| 日本午夜精品视频在线观看| 国产精品乱子伦一区二区三区| 日本精品理论在线观看| 人妻少妇系列中文字幕| 激情视频在线视频在线视频| 欧美一级内射一色桃子| 91老熟妇嗷嗷叫太91| 99久久人妻中文字幕| 欧美午夜伦理在线观看| 九九蜜桃视频香蕉视频| 九九热精彩视频在线免费| 免费在线观看激情小视频| 中文字幕人妻一区二区免费| 太香蕉久久国产精品视频| 国产性情片一区二区三区| 亚洲国产色婷婷久久精品| 欧美精品久久男人的天堂| 欧美区一区二区在线观看| 亚洲精品福利视频你懂的| 精品女同一区二区三区| 日韩不卡一区二区三区色图| 国内精品偷拍视频久久|