本文關(guān)鍵詞：不同體質(zhì)大鼠攻毒發(fā)熱后中樞發(fā)熱解熱介質(zhì)含量變化的比較研究　出處：《黑龍江中醫(yī)藥大學(xué)》2009年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 體質(zhì)病理 發(fā)熱 體溫 PGE-2 AVP

【摘要】： 目的:研究常體、熱體、寒體各組間在攻毒發(fā)熱后下丘腦PGE-2、AVP、血清中IL-1β含量變化。揭示不同體質(zhì)大鼠攻毒發(fā)熱后中樞發(fā)熱解熱介質(zhì)含量的變化與體質(zhì)的相關(guān)性。 方法:參照文獻(xiàn)造模方法,經(jīng)過(guò)預(yù)實(shí)驗(yàn)改良飼養(yǎng)方法,復(fù)制常體、熱體、寒體大鼠模型。喂養(yǎng)大鼠四周后,每天固定時(shí)間測(cè)量大鼠肛溫,連續(xù)3天。常體組為均值±0.2℃,熱體或寒體組為均值±1℃,兩組體溫相差在2℃以上,證明造模成功。用大腸桿菌內(nèi)毒素攻毒法復(fù)制大鼠發(fā)熱模型,采用放射免疫法測(cè)定大鼠攻毒發(fā)熱后下丘腦PGE-2、AVP含量、血清中IL-1β的含量。 結(jié)果:常體、熱體、寒體不同體質(zhì)大鼠攻毒發(fā)熱后體溫波動(dòng)有差別,寒體組對(duì)攻毒反應(yīng)強(qiáng)烈,體溫波動(dòng)大,但反應(yīng)時(shí)間相對(duì)滯后,熱體組和常體組體溫波動(dòng)相對(duì)較小。發(fā)熱介質(zhì)IL-1β及PGE-2含量與ΔT變化曲線一致,1h IL-1β、PGE-2含量比較不同體質(zhì)之間存在顯著差異(p＜0.05),3h常體組IL-1β、PGE-2含量大于寒體組(p＜0.01)、大于熱體組(P＜0.05),6h寒體組IL-1β含量小于熱體組(p＜0.05),寒體組PGE-2含量小于常體組(p＜0.01)。 負(fù)反饋因素AVP與體溫曲線呈反向變化,3hAVP熱體組小于寒體組(p＜0.05),熱體組大于常體組(P＜0.01),6h AVP寒體組大于熱體組(P＜0.05)。 結(jié)論:體質(zhì)的差異決定了攻毒發(fā)熱后,中樞發(fā)熱和解熱介質(zhì)含量的差異性。
[Abstract]:Objective: to study the hypothalamic PGE-2 AVP in the hypothalamus after the attack of toxin and fever among the groups of normal body, hot body and cold body. The change of IL-1 尾 content in serum revealed the correlation between the changes of central fever and antipyretic medium in rats with different physical constitution. Methods: according to the method of model making in literature, the rat model of normal body, hot body and cold body was established by preexperiment and improved feeding method. After feeding rats for four weeks, the anus temperature of rats was measured at a fixed time every day. For 3 consecutive days, the mean value of normal body group was 鹵0.2 鈩，

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