本文關(guān)鍵詞：獎(jiǎng)賞記憶改善焦慮行為的小鼠模型及機(jī)制初探　出處：《生物化學(xué)與生物物理進(jìn)展》2015年07期 　論文類型：期刊論文

  更多相關(guān)文章： 高架十字迷宮 獎(jiǎng)賞記憶 焦慮行為 蛋白激酶C

【摘要】：焦慮是當(dāng)今社會(huì)最普遍的精神障礙之一.藥物療法和心理療法是焦慮癥的主要治療手段,后者因無(wú)副作用且不易反復(fù)而倍受重視.在焦慮癥的心理行為療法中,獎(jiǎng)賞記憶緩解焦慮的模型及機(jī)制是一個(gè)重要的科學(xué)問(wèn)題.對(duì)這一問(wèn)題的研究將有助于理解其內(nèi)在機(jī)制并開發(fā)更好的治療焦慮癥的方法.基于經(jīng)典的小鼠焦慮行為評(píng)測(cè)工具——高架十字迷宮,我們首先考查了焦慮評(píng)測(cè)結(jié)合行為訓(xùn)練的可行性,發(fā)現(xiàn)小鼠在高架十字迷宮上反復(fù)評(píng)測(cè)后行為達(dá)到穩(wěn)態(tài),則可通過(guò)在開放臂末端設(shè)置食物獎(jiǎng)賞來(lái)研究獎(jiǎng)賞記憶對(duì)焦慮行為的影響;然后通過(guò)實(shí)驗(yàn)證明短期獎(jiǎng)賞訓(xùn)練和無(wú)獎(jiǎng)賞的強(qiáng)制開放臂暴露不能改善焦慮行為;進(jìn)而確定并驗(yàn)證了獎(jiǎng)賞訓(xùn)練改善焦慮行為的正確方式;最后在此行為模型中應(yīng)用有致遺忘效應(yīng)的蛋白激酶C的抑制劑白屈菜赤堿(chelerythrine),發(fā)現(xiàn)獎(jiǎng)賞記憶形成被抑制伴隨著焦慮行為改善的削弱.初步揭示了此行為模型涉及的細(xì)胞分子機(jī)制.
[Abstract]:Today's social anxiety is one of the most common disorder. Drug therapy and psychological therapy is the main treatment of anxiety disorders, the latter with no side effect and is not easy to repeatedly has attracted much attention. In the psychological behavior therapy of anxiety disorders, reward memory model and the mechanism of relieving anxiety is an important method to study the scientific problems. The answer to this question will help to understand the intrinsic mechanism and the development of better treatment of anxiety disorders. The classic anxiety behavior of mice evaluation tools -- Based on the elevated plus maze, we first examine the anxiety evaluation combined with behavior training is feasible, found that the mice in the elevated plus maze after repeated evaluation behavior at steady state is. By setting up a food reward at the end of the open arms to study the effects of anxiety on reward memory behavior; then experiments show that short-term reward training and non reward forced open arms violence Dew cannot improve the anxiety behavior; and to determine and verify the correct way to reward training improve the anxiety behavior; finally this behavior model in the application of induced forgetting effect of protein kinase C inhibitor chelerythrine (chelerythrine), found that reward memory formation was inhibited with the anxiety behavior improvement weakened. Reveal the cellular and molecular mechanism the behavior of the model.

【作者單位】： 中國(guó)科學(xué)院生物物理研究所腦與認(rèn)知科學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室;中國(guó)科學(xué)院大學(xué);
【基金】：國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973)(2013CB531304,2011CB504405) 國(guó)家自然科學(xué)基金(30990261,81171033,81471123)資助項(xiàng)目~~
【分類號(hào)】：R749.72;R-332
【正文快照】： *國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973)(2013CB531304,2011CB504405)焦慮癥,源于對(duì)未來(lái)事件或所處情境的一種泛化不可控的過(guò)度憂懼,是當(dāng)今社會(huì)最為普遍的一種心理障礙[1-2].前額葉皮層、杏仁核和海馬及其相互作用被認(rèn)為是焦慮癥病理的主要源頭[3-9],同時(shí)這些腦區(qū)也是負(fù)責(zé)信息存儲(chǔ)的

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王芳;王超;江偉;鄧廿慶;顧秀萍;陳貴海;;中年C57BL/6小鼠焦慮行為改變[J];安徽農(nóng)業(yè)大學(xué)學(xué)報(bào);2008年04期

2 張燕;鄭偉;丁瑩;徐藝玫;史深;;BALB/c和C57BL/6J小鼠高架十字迷宮焦慮表現(xiàn)行為比較[J];疾病預(yù)防控制通報(bào);2012年03期

3 張雪;黃仕營(yíng);張q，

本文編號(hào)：1360718