不同治療方案對老年膠質(zhì)母細胞瘤患者生存期的影響
發(fā)布時間:2019-07-29 12:17
【摘要】:目的研究不同治療方案對老年膠質(zhì)母細胞瘤患者生存期的影響。方法采用單因素生存分析法,生存曲線的比較采用log-rank檢驗,多因素生存分析采用Cox回歸模型,分析治療方案、年齡、是否服用替莫唑胺、KPS評分、腫瘤部位、大小等因素對生存時間的影響。結(jié)果通過單因素生存分析,老年膠質(zhì)母細胞瘤患者的生存期與其治療方案(放療、手術局部切除、手術全部切除)、年齡(≤75歲、75歲)、是否服用替莫唑胺、KPS評分(70分、70~90分、90分)等因素有關(P0.05);而生存期與腫瘤部位(額、顳、頂、枕葉)、大小(≤4 cm、4 cm)無關(P0.05)。多因素分析:治療方案為手術全部切除、服用替莫唑胺、KPS評分越高(70分、70~90分、90分)等因素為老年膠質(zhì)母細胞瘤患者的生存期保護因素(P0.05);而年齡越大則表現(xiàn)為危險因素(P0.05)。生存期與腫瘤部位(額、顳、頂、枕葉)、大小(≤4 cm、4 cm)等因素的分析提示差異無統(tǒng)計學意義(P0.05)。結(jié)論治療方案為手術全部切除、服用替莫唑胺、KPS評分越高(70分、70~90分、90分)等因素為老年膠質(zhì)母細胞瘤患者的生存期的保護因素;年齡越大則表現(xiàn)為危險因素。腫瘤大小及腫瘤部位對中位生存時間無明顯影響。
[Abstract]:Objective to study the effect of different treatments on the survival time of elderly patients with glioblastomas. Methods single factor survival analysis was used, log-rank test was used to compare survival curve, and Cox regression model was used for multivariate survival analysis. The effects of treatment plan, age, whether or not to take temozolamine, KPS score, tumor location and size on survival time were analyzed. Results by univariate survival analysis, the survival time of elderly patients with glioblastomas was related to the treatment regimen (radiotherapy, local resection, total resection), age (鈮,
本文編號:2520499
[Abstract]:Objective to study the effect of different treatments on the survival time of elderly patients with glioblastomas. Methods single factor survival analysis was used, log-rank test was used to compare survival curve, and Cox regression model was used for multivariate survival analysis. The effects of treatment plan, age, whether or not to take temozolamine, KPS score, tumor location and size on survival time were analyzed. Results by univariate survival analysis, the survival time of elderly patients with glioblastomas was related to the treatment regimen (radiotherapy, local resection, total resection), age (鈮,
本文編號:2520499
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