【摘要】：目的:探討丁苯酞氯化鈉注射液在頸內(nèi)動(dòng)脈狹窄患者介入治療圍手術(shù)期的臨床療效及其安全性?方法:選取80例介入治療的頸內(nèi)動(dòng)脈狹窄患者,隨機(jī)分為治療組及對(duì)照組各40例;兩組均給予常規(guī)治療阿司匹林腸溶片100mg日一次,氯吡格雷75mg日一次,立普妥20mg日一次,而治療組,基于對(duì)照組基礎(chǔ)之上加用丁苯酞氯化鈉注射液100ml日二次,療程為14天。兩組進(jìn)行治療的時(shí)間為兩周?兩組在治療前及治療后記錄腦血容量(cerebral blood volume,CBV)?腦血流量(cerebral blood flow,CBF)?平均通過時(shí)間(mean transit time,MTT)及達(dá)峰時(shí)間(time to peak,TTP)參數(shù),進(jìn)行神經(jīng)功能缺損程度評(píng)分?并通過SPSS19.0進(jìn)行統(tǒng)計(jì),所得到的結(jié)果再利用t進(jìn)行檢驗(yàn),對(duì)每個(gè)變量之間所存在的差異進(jìn)行統(tǒng)計(jì),觀察有無統(tǒng)計(jì)學(xué)意義?結(jié)果:與對(duì)照組相比,不僅治療后神經(jīng)功能缺損程度評(píng)分治療組明顯低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),而且治療后腦血容量(cerebral blood volume,CBV)、腦血流量(cerebral blood flow,CBF)、平均通過時(shí)間(mean transit time,MTT)及達(dá)峰時(shí)間(time to peak,TTP)參數(shù)差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:丁苯酞氯化鈉注射液是一類新型腦保護(hù)藥物,具有抗缺血作用,對(duì)頸內(nèi)動(dòng)脈狹窄患者介入圍手術(shù)期的治療安全有效。
[Abstract]:Objective: to investigate the clinical efficacy and safety of butylphthalein sodium chloride injection in perioperative period of interventional therapy in patients with internal carotid artery stenosis. Methods: 80 patients with internal carotid artery stenosis were randomly divided into treatment group (n = 40) and control group (n = 40). Both groups were treated with aspirin enteric-coated tablets once a day, clopidogrel 75mg once a day and Lipitor 20 mg daily, while the treatment group was treated with 100 ml sodium butylphthalein chloride injection twice a day for 14 days. The treatment time of the two groups was two weeks? The cerebral blood volume (cerebral blood volume,CBV) was recorded before and after treatment in the two groups. Cerebral blood flow (cerebral blood flow,CBF)? The mean transit time (mean transit time,MTT) and peak time (time to peak,TTP) parameters were used to score the degree of neurological deficit. And through SPSS19.0 statistics, the results are tested by t, and the differences between each variable are statistically analyzed. Is there any statistical significance to observe? Results: compared with the control group, not only the score of neurological deficit in the treatment group was significantly lower than that in the control group (P 0.05), but also the cerebral blood volume (cerebral blood volume,CBV), cerebral blood flow (cerebral blood flow,CBF), mean transit time (mean transit time,MTT) and peak time (time to peak,TTP) parameters were significantly different (P 0.05). Conclusion: butylphthalein sodium chloride injection is a new type of brain protective drug, which has anti-ischemic effect and is safe and effective in the perioperative treatment of patients with internal carotid artery stenosis.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R743.3

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