【摘要】：目的：影像學(xué)研究發(fā)現(xiàn)偏頭痛患者大腦結(jié)構(gòu)及任務(wù)相關(guān)腦功能發(fā)生改變，本研究采用靜息態(tài)功能磁共振成像（resting-state functional magneticresonance imaging，rfMRI）技術(shù)研究月經(jīng)性偏頭痛患者發(fā)作間期靜息狀態(tài)下腦功能的改變，以便更好地認(rèn)識其病理生理學(xué)機(jī)制。 方法：對10例發(fā)作間期的月經(jīng)性偏頭痛患者和10例受教育程度、年齡相匹配的健康對照行rfMRI掃描，分別計(jì)算在三個不同頻段下（slow-4:0.027-0.073Hz；slow-5:0.01-0.027Hz；典型頻段：0.01-0.08Hz）的低頻振幅（amplitude of low-frequency fluctuations，ALFF），得出兩樣本在典型頻段下有顯著統(tǒng)計(jì)學(xué)差異的腦區(qū)，并用方差分析得出兩樣本和兩頻段（slow-4、slow-5）之間的頻率主效應(yīng)、組間主效應(yīng)和交互效應(yīng)的腦區(qū)。 結(jié)果： 1病例組和對照組ALFF值均顯著增高的腦區(qū)有前后扣帶回皮層、楔前葉、下頂葉、內(nèi)側(cè)前額葉皮質(zhì)、島葉等（P0.05Alphasim corrected）。 2病例組左側(cè)額葉ALFF值較對照組顯著增強(qiáng)（P0.05Alphasimcorrected）；病例組雙側(cè)枕葉、雙側(cè)丘腦ALFF值較對照組明顯減弱（P0.05Alphasim corrected）。 3組間主效應(yīng)顯示與對照組相比，病例組左側(cè)額葉ALFF值顯著增強(qiáng)，，枕葉、雙側(cè)丘腦、左側(cè)小腦ALFF值顯著減弱（P0.05Alphasimcorrected）；頻率主效應(yīng)顯示slow-4ALFF值明顯高于slow-5的腦區(qū)在基底節(jié)、丘腦、楔前葉、扣帶皮層、梭狀回、中腦，低于slow-5的腦區(qū)有舌回、額下回、顳中回、腹內(nèi)側(cè)前額葉（P0.05Alphasim corrected）；存在交互作用的腦區(qū)是左側(cè)島葉及視覺皮層（P0.05Alphasim corrected）。 結(jié)論：月經(jīng)性偏頭痛患者發(fā)作間期存在廣泛的皮層及皮層下腦區(qū)的功能異常，并且異常的神經(jīng)自發(fā)活動具有頻率依賴性。
[Abstract]:Objective: imaging studies showed changes in brain structure and task-related brain function in migraine patients. Rest-state functional magnetic resonance imaging (resting-state functional magneticresonance imaging,) was used in this study. RfMRI) technique was used to study the changes of brain function during interictal rest in patients with menstrual migraine in order to better understand its pathophysiological mechanism. Methods: 10 interictal menstrual migraine patients and 10 age-matched healthy controls were scanned with rfMRI and calculated at three different frequency bands (slow-4:0.027-0.073Hz;). Slow-5:0.01-0.027Hz; The low frequency amplitude (amplitude of low-frequency fluctuations,ALFF) of the typical frequency band: 0.01-0.08Hz), the brain region with significant statistical difference between the two samples in the typical frequency band is obtained, and the two samples and the two frequency segments (slow-4,) are obtained by the analysis of variance. Slow-5) between the frequency main effects, the inter-group main effects and the interactive effects of the brain regions. Results: (1) there were anterior and posterior cingulate cortex, anterior cuneiform lobe, inferior parietal lobe, medial prefrontal cortex, island lobe and so on in the brain areas where ALFF was significantly increased in both the case group and the control group (P0.05Alphasim corrected). 2 the ALFF value of left frontal lobe in the case group was significantly higher than that in the control group (P0.05Alphasimcorrected), and the ALFF value in the bilateral occipital lobe and thalamus in the case group was significantly lower than that in the control group (P0.05Alphasimcorrected). Compared with the control group, the ALFF values in the left frontal lobe, occipital lobe, bilateral thalamus and left cerebellum were significantly decreased in the three groups (P0.05Alphasimcorrected), and the left frontal lobe in the case group was significantly higher than that in the control group (P < 0.05). The main effect of frequency showed that the value of slow-4ALFF was significantly higher than that of slow-5 in basal ganglia, thalamus, anterior wedge lobe, cingulate cortex, fusiform gyrus, midbrain, and lower than slow-5 had tongue gyrus, inferior frontal gyrus and middle temporal gyrus. Ventral prefrontal lobe (P0.05Alphasim corrected);) The interacting brain areas are the left insular lobe and visual cortex (P0.05Alphasim corrected). Conclusion: in patients with menstrual migraine, there are extensive functional abnormalities in cortex and subcortical region during interictal period, and abnormal spontaneous nerve activity is frequency-dependent.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R747.2;R445.2

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相關(guān)期刊論文 前2條

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2 劉虎;范國光;徐克;李煥煥;邵建;;低頻振幅fMRI評價(jià)精神分裂癥患者靜息狀態(tài)下腦功能活動[J];中國醫(yī)學(xué)影像技術(shù);2010年09期

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