基于BCI-FES的肢體功能重建系統(tǒng)研究
發(fā)布時(shí)間：2019-03-06 09:40
【摘要】：隨著社會(huì)老齡化問(wèn)題日益凸顯,腦卒中發(fā)病率也在逐年升高,臨床上對(duì)于有效的腦卒中康復(fù)療法有著迫切的需求。相對(duì)傳統(tǒng)的機(jī)械式被動(dòng)康復(fù)輔具,圍繞功能性電刺激(FES)進(jìn)行的肢體功能重建技術(shù)被普遍認(rèn)為是一種有效的臨床康復(fù)訓(xùn)練工具。但截至目前,該技術(shù)尚無(wú)法直接通過(guò)患者的自主意識(shí)實(shí)現(xiàn)運(yùn)動(dòng)控制,進(jìn)而影響了肢體功能重建技術(shù)在我國(guó)臨床康復(fù)方面的大規(guī)模應(yīng)用和推廣。本文將想象動(dòng)作型腦-機(jī)接口(BCI)與FES技術(shù)結(jié)合,在體外重建腦卒中患者的運(yùn)動(dòng)神經(jīng)通路,引入患者的主觀意識(shí)來(lái)增加其在FES康復(fù)訓(xùn)練中的參與度,從而逐漸恢復(fù)肢體運(yùn)動(dòng)機(jī)能。研究中根據(jù)腦卒中康復(fù)的臨床實(shí)際需求,設(shè)計(jì)并完成了符合YY0607-2007標(biāo)準(zhǔn)的神經(jīng)肌肉電刺激器,在此基礎(chǔ)上搭建了完整的BCI-FES系統(tǒng),利用共空間模式(CSP)對(duì)右側(cè)肢體想象動(dòng)作的事件相關(guān)去同步(ERD)腦電信號(hào)進(jìn)行特征提取,然后利用支持向量機(jī)(SVM)區(qū)分想象過(guò)程中的運(yùn)動(dòng)與靜息狀態(tài),再將想象動(dòng)作誘發(fā)電位驅(qū)動(dòng)輸出FES裝置的控制命令,同時(shí)對(duì)分類閾值進(jìn)行優(yōu)化,降低其誤觸發(fā)率。2名健康被試與2名腦卒中偏癱患者參與了異步腦-機(jī)接口臨床實(shí)驗(yàn)。研究中利用臨床康復(fù)量表、腦地形圖和對(duì)側(cè)占優(yōu)系數(shù)作為評(píng)價(jià)手段,對(duì)腦卒中患者使用BCI-FES系統(tǒng)的康復(fù)效果進(jìn)行了評(píng)價(jià),結(jié)果發(fā)現(xiàn)患者臨床量表得分有顯著的提高。而從腦地形圖與對(duì)側(cè)占優(yōu)系數(shù)來(lái)看,中風(fēng)患者同側(cè)占優(yōu)現(xiàn)象慢慢消失,逐漸轉(zhuǎn)變?yōu)閷?duì)側(cè)占優(yōu),這說(shuō)明通過(guò)康復(fù)訓(xùn)練,患側(cè)肢體映射的對(duì)側(cè)腦區(qū)功能正在逐漸恢復(fù),同時(shí)同側(cè)腦區(qū)的運(yùn)動(dòng)皮層代償功能也逐漸減弱。本研究臨床試驗(yàn)結(jié)果證實(shí)腦卒中患者在經(jīng)過(guò)文中設(shè)計(jì)的BCI-FES系統(tǒng)訓(xùn)練后,肢體運(yùn)動(dòng)功能可獲得較為明顯的恢復(fù),這也體現(xiàn)了BCI-FES系統(tǒng)在腦卒中肢體功能重建中的巨大潛力。
[Abstract]:With the aging of society becoming increasingly prominent, the incidence of stroke is also increasing year by year. There is an urgent need for effective rehabilitation therapy for stroke. In contrast to the traditional mechanical passive rehabilitation aids, the technique of limb function reconstruction around functional electrical stimulation (FES) is generally regarded as an effective training tool for clinical rehabilitation. However, up to now, the technique has not been able to achieve motor control directly through the patient's autonomous consciousness, thus affecting the large-scale application and popularization of limb function reconstruction technology in clinical rehabilitation in China. In this paper, the imaginative brain-computer interface (BCI) and FES technique were combined to reconstruct the motor nerve pathway of stroke patients in vitro, and the subjective consciousness of the patients was introduced to increase their participation in FES rehabilitation training. As a result, the motor function of the limbs is gradually restored. According to the clinical needs of stroke rehabilitation, a neuromuscular electrical stimulator according to YY0607-2007 standard was designed and completed in this study, and a complete BCI-FES system was built on this basis. The event-related de-synchronous (ERD) EEG signals of the right limbs are extracted by using the common space model (CSP), and then the motion and rest states in the imagination process are distinguished by support vector machine (SVM). At the same time, the threshold of classification was optimized to reduce the mistriggering rate. Two healthy subjects and two stroke hemiplegic patients were involved in the asynchronous brain-computer interface (ACBI) clinical experiment. The control command of the output FES device was driven by the imaginary action evoked potential, and the classification threshold was optimized to reduce the mistriggering rate. In this study, clinical rehabilitation scale, brain map and contralateral dominance coefficient were used to evaluate the rehabilitation effect of BCI-FES system in stroke patients. The results showed that the scores of clinical scale of stroke patients were significantly improved. From the view of brain activity map and contralateral dominance coefficient, the phenomenon of ipsilateral dominance gradually disappeared and gradually turned to contralateral dominance, which indicated that the contralateral brain function of the affected limb mapping was gradually recovering through rehabilitation training. At the same time, the motor cortex compensation function of ipsilateral brain area also gradually weakened. The results of clinical trials show that the limb motor function of stroke patients can be recovered obviously after the training of BCI-FES system designed in this paper, which also shows the great potential of BCI-FES system in the reconstruction of limb function in stroke.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.3;R496
本文編號(hào)：2435414
[Abstract]:With the aging of society becoming increasingly prominent, the incidence of stroke is also increasing year by year. There is an urgent need for effective rehabilitation therapy for stroke. In contrast to the traditional mechanical passive rehabilitation aids, the technique of limb function reconstruction around functional electrical stimulation (FES) is generally regarded as an effective training tool for clinical rehabilitation. However, up to now, the technique has not been able to achieve motor control directly through the patient's autonomous consciousness, thus affecting the large-scale application and popularization of limb function reconstruction technology in clinical rehabilitation in China. In this paper, the imaginative brain-computer interface (BCI) and FES technique were combined to reconstruct the motor nerve pathway of stroke patients in vitro, and the subjective consciousness of the patients was introduced to increase their participation in FES rehabilitation training. As a result, the motor function of the limbs is gradually restored. According to the clinical needs of stroke rehabilitation, a neuromuscular electrical stimulator according to YY0607-2007 standard was designed and completed in this study, and a complete BCI-FES system was built on this basis. The event-related de-synchronous (ERD) EEG signals of the right limbs are extracted by using the common space model (CSP), and then the motion and rest states in the imagination process are distinguished by support vector machine (SVM). At the same time, the threshold of classification was optimized to reduce the mistriggering rate. Two healthy subjects and two stroke hemiplegic patients were involved in the asynchronous brain-computer interface (ACBI) clinical experiment. The control command of the output FES device was driven by the imaginary action evoked potential, and the classification threshold was optimized to reduce the mistriggering rate. In this study, clinical rehabilitation scale, brain map and contralateral dominance coefficient were used to evaluate the rehabilitation effect of BCI-FES system in stroke patients. The results showed that the scores of clinical scale of stroke patients were significantly improved. From the view of brain activity map and contralateral dominance coefficient, the phenomenon of ipsilateral dominance gradually disappeared and gradually turned to contralateral dominance, which indicated that the contralateral brain function of the affected limb mapping was gradually recovering through rehabilitation training. At the same time, the motor cortex compensation function of ipsilateral brain area also gradually weakened. The results of clinical trials show that the limb motor function of stroke patients can be recovered obviously after the training of BCI-FES system designed in this paper, which also shows the great potential of BCI-FES system in the reconstruction of limb function in stroke.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.3;R496
【參考文獻(xiàn)】
相關(guān)期刊論文 前2條
1 楊紅宇;徐鵬;陳彥;;異步腦機(jī)接口技術(shù)現(xiàn)狀及發(fā)展趨勢(shì)[J];中國(guó)生物醫(yī)學(xué)工程學(xué)報(bào);2011年05期
2 陳果,呂俊芳,李靜;腦電信號(hào)源腦電圖定位方法的綜述[J];航空計(jì)測(cè)技術(shù);2003年02期
相關(guān)碩士學(xué)位論文 前1條
1 靳靜娜;基于FES的下肢運(yùn)動(dòng)神經(jīng)假體系統(tǒng)設(shè)計(jì)與研究[D];天津大學(xué);2008年
，本文編號(hào)：2435414
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/2435414.html
最近更新
教材專著
