【摘要】：背景:腦卒中后焦慮障礙(PSAD)是腦血管病后常見的并發(fā)癥之一,因為其可嚴重影響患者及其照顧者的生活質(zhì)量,甚至可增加腦血管病患者的病死率,因此對腦卒中后焦慮的早期診斷及治療是提高患者及照顧者生存質(zhì)量和降低病死率的有效途徑。但目前關(guān)于藥物治療腦卒中后焦慮的專門臨床研究較少。黛力新是治療焦慮障礙非常有效的一種化合物復(fù)方制劑,然而,目前僅有很少一部分的試驗研究了黛力新對腦卒中后焦慮的治療效果。目的:本文旨在通過Meta分析評價黛力新治療腦卒中后焦慮的療效,為腦卒中后焦慮的治療提供具有循證醫(yī)學(xué)的最佳治療方案。方法:計算機檢索數(shù)據(jù)庫(Cochrance Library、PubMed、WANFANG、CNKI、WEIPU等),查閱自1989年-2017年公開發(fā)表的有關(guān)黛力新治療腦卒中后焦慮的相關(guān)文獻。并根據(jù)納入和排除的標準對文獻進行篩選,并對篩選出的文章進行方法及質(zhì)量評價,使用RevMan5.1軟件對納入的文章進行數(shù)據(jù)分析。結(jié)果:經(jīng)過篩選,最終納入6篇隨機對照試驗(RCT)文獻,總共有600名患者。根據(jù)Meta分析數(shù)據(jù)顯示,最終可得出黛力新治療腦卒中后焦慮的治療是有效的結(jié)論(OR為7.10 95%CI值是4.36-11.55,P0.05,I2=0)。結(jié)論:本文通過對現(xiàn)有RCT試驗進行的Meta分析,得出黛力新對腦卒中后焦慮有明確的治療效果。但是結(jié)果可能因為低質(zhì)量的RCT而出現(xiàn)偏差,同時所納入的文獻的樣本量均較小,故需要進行更多的高質(zhì)量、大樣本量的RCT來驗證。
[Abstract]:Background: post-stroke anxiety disorder (PSAD) is one of the common complications after cerebrovascular disease, because it can seriously affect the quality of life of patients and their caregivers, and even increase the fatality rate of cerebrovascular disease patients. Therefore, the early diagnosis and treatment of post-stroke anxiety is an effective way to improve the quality of life and reduce the mortality of patients and caregivers. However, there are few clinical studies on drug treatment of post-stroke anxiety. Delixine is an effective compound for anxiety disorder. However, only a small number of trials have studied the therapeutic effect of Delixin on post-stroke anxiety. Aim: to evaluate the efficacy of Delixin in the treatment of post-stroke anxiety by Meta analysis, and to provide evidence-based medicine for the treatment of post-stroke anxiety. Methods: a computer-based search database (Cochrance Library,PubMed,WANFANG,CNKI,WEIPU et al.) was used to review the published literatures on the treatment of post-stroke anxiety with Delixin from 1989 to 2017. According to the criteria of inclusion and exclusion, the literature was screened, the methods and quality of the selected articles were evaluated, and the data of the articles were analyzed by using RevMan5.1 software. Results: six randomized controlled trials (RCT) were selected and included in 6 randomized controlled trials (RCTs) with a total of 600 patients. According to the data of Meta analysis, it was concluded that Delixin was effective in the treatment of post-stroke anxiety (OR = 7.10 95%CI = 4.36, 11.55, P 0.05, I _ 2 ~ 0). Conclusion: according to the Meta analysis of the existing RCT test, it is concluded that Delixin has a definite therapeutic effect on post-stroke anxiety. However, the results may be biased because of the low quality RCT, and the sample size of the literature is small. Therefore, more high quality, large sample size RCT should be carried out to verify the results.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R743.3;R749.72

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