【摘要】：目的:本研究意在觀察溫陽復(fù)元方對缺血性中風(fēng)恢復(fù)期的臨床綜合療效及其對S-100B蛋白、神經(jīng)肽Y、超敏C-反應(yīng)蛋白的影響,以明確其療效,并初步探討其療效機(jī)制,并為其臨床應(yīng)用打下堅(jiān)實(shí)的基礎(chǔ)。方法:選擇符合缺血性中風(fēng)恢復(fù)期診斷標(biāo)準(zhǔn)的患者80例,采取區(qū)組隨機(jī)的原則分為治療組(溫陽復(fù)元方+西醫(yī)常規(guī)治療,簡稱溫陽復(fù)元方組)、對照組(補(bǔ)陽還五湯+西醫(yī)常規(guī)治療,簡稱補(bǔ)陽還五湯組)各40例。治療前及治療4周后進(jìn)行臨床綜合療效以及實(shí)驗(yàn)室指標(biāo)(S-100B蛋白、神經(jīng)肽Y、超敏C-反應(yīng)蛋白)評定,并前后進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:(1)、兩組臨床綜合療效比較:治療組37例,基本痊愈7例,顯效17例,有效10例,無效3例,總有效率91.89%;對照組36例,基本痊愈4例,顯效12例,有效10例,無效10例,總有效率72.22%;兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P0.05),表明溫陽復(fù)元方組效果優(yōu)于補(bǔ)陽還五湯組。(2)、兩組S-100B蛋白(S-100B protein)比較:兩組患者治療前血清中S-100B的含量比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后對比,兩組之間存在差異性(P0.05),表明溫陽復(fù)元方組下調(diào)S-100B的效果優(yōu)于補(bǔ)陽還五湯組。(3)、兩組神經(jīng)肽Y(Neuropeptide Y,NPY)比較:兩組患者治療前血漿中NPY的含量比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后對比,兩組之間存在差異性(P0.05),表明溫陽復(fù)元方組下調(diào)血漿NPY的效果優(yōu)于補(bǔ)陽還五湯組。(4)、兩組超敏C-反應(yīng)蛋白(high-sensitivity C-reactive protein,hs-CRP)比較:兩組患者治療前血清中hs-CRP的含量比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后對比,兩組之間存在差異性(P0.05),表明溫陽復(fù)元方組下調(diào)血清hs-CRP的效果優(yōu)于補(bǔ)陽還五湯組。結(jié)論:溫陽復(fù)元方聯(lián)合西醫(yī)常規(guī)療法治療缺血性中風(fēng)恢復(fù)期療效優(yōu)于補(bǔ)陽還五湯聯(lián)合西醫(yī)常規(guī)療法,初步揭示了溫陽復(fù)元方的作用機(jī)制可能與下調(diào)S-100B、NPY、hs-CRP含量表達(dá)有關(guān)。
[Abstract]:Objective: To study the effect of Wenyang Fuyuan on the recovery of ischemic stroke and its effect on S-100B protein, neuropeptide Y and hypersensitive C-reactive protein. Methods: 80 patients with ischemic stroke recovery criteria were selected, and the random principle of the group was divided into treatment group (Wenyang Fuyuan + Western medicine general treatment, hereinafter referred to as" Wenyang Fuyuan "group), and the control group (Bu Yang, Wu Tang + Western medicine). 40 cases of each of the five decoction groups. The clinical comprehensive curative effect and the laboratory index (S-100B protein, neuropeptide Y and hypersensitive C-reactive protein) were evaluated before and after treatment for 4 weeks, and the statistical analysis was performed before and after treatment. Results: (1) In the treatment group, 37 cases were cured, 7 cases were cured, 17 cases were effective, 10 cases were effective, 3 cases were ineffective, the total effective rate was 91.89%, 36 cases in the control group, 4 cases were basically cured, 12 cases were effective, 10 cases were effective, and the total effective rate was 72.22%. The difference of the two groups was statistically significant (P <0.05), indicating that the effect of the Wenyang Fuyuan group was superior to that of the Wuyang Huanwu Decoction group. (2) The S-100B protein in the two groups was compared with that of S-100B protein in the two groups (P0.05). There was a difference between the two groups (P0.05). (3) There was no significant difference between the two groups of neuropeptide Y (NPY). There was no significant difference between the two groups (P0.05). There was a difference between the two groups after the treatment (P0.05). (4) The high-sensitivity C-reactive protein (hs-CRP) in the two groups showed no significant difference in the levels of hs-CRP in the two groups (P0.05). The results showed that the effect of reducing serum hs-CRP in Wenyang Fuyuan group was superior to that of the Wuyang Huanwu decoction group. Conclusion: The curative effect of Wenyang Fu-yuan combined with western medicine in the treatment of ischemic stroke is superior to that of the traditional Chinese medicine for the treatment of ischemic stroke. It is suggested that the mechanism of warming Yang Fu-yuan is related to the down-regulation of the content of S-100B, NPY, hs-CRP.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R743.3

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