腦卒中后抑郁患者腦網(wǎng)絡(luò)拓?fù)涓淖兊难芯?/H1>
發(fā)布時(shí)間：2019-01-01 07:43
【摘要】：目的探討腦卒中后抑郁(PSD)患者腦網(wǎng)絡(luò)拓?fù)鋵傩缘淖兓７椒▽?9例非PSD腦卒中患者(Non-PSD組)及19例PSD患者(PSD組)進(jìn)行DTI檢查。使用確定性纖維追蹤方法基于部分各向異性值構(gòu)建大腦白質(zhì)結(jié)構(gòu)網(wǎng)絡(luò)。使用圖論方法分析兩組患者的腦網(wǎng)絡(luò)拓?fù)鋵傩?并對兩組大腦網(wǎng)絡(luò)聚類系數(shù)(Cp)、特征路徑長度(Lp)、歸一化的聚類系數(shù)(γ)、標(biāo)準(zhǔn)特征路徑長度(λ)、小世界屬性值(σ)、全局效率(Eglob)及局部效率(Eloc)進(jìn)行比較。結(jié)果兩組均有σ1,Non-PSD組σ明顯高于PSD組(P0.05)。兩組Eglob、Eloc、Lp、λ、Cp、γ比較差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。Non-PSD組右嗅皮質(zhì)Cp明顯高于PSD組,左背外側(cè)額上回、右背外側(cè)額上回、右眶部額上回、額中回左、左島蓋部額下回、左三角部額下回、左內(nèi)側(cè)和旁扣帶腦回、右海馬、右角回、左尾狀核、左豆?fàn)钌n白球、左顳上回Cp均明顯低于PSD組(均P0.05)。NonPSD組左眶部額下回、右眶部額下回、左內(nèi)側(cè)額上回、左前扣帶和旁扣帶腦回、右前扣帶和旁扣帶腦回、左后扣帶回、左海馬、右海馬、右丘腦、右顳中回節(jié)點(diǎn)效率均明顯低于PSD組(均P0.05)。結(jié)論 PSD患者大腦結(jié)構(gòu)網(wǎng)絡(luò)均具有小世界屬性,部分腦區(qū)Cp發(fā)生改變,部分腦區(qū)節(jié)點(diǎn)效率也發(fā)生改變。
[Abstract]:Objective to investigate the changes of brain network topology in (PSD) patients with post-stroke depression. Methods DTI examination was performed in 29 patients with non-PSD stroke (Non-PSD group) and 19 patients with PSD (PSD group). The deterministic fiber tracing method is used to construct the white matter structure network based on partial anisotropy. The topological properties of brain network in two groups of patients were analyzed by using graph theory method, and the normalized clustering coefficients (緯), standard characteristic path lengths (位) of the (Cp), characteristic path length of the two groups of brain network clustering coefficients, and the normalized clustering coefficients (緯), standard characteristic path lengths (位) of the two groups of brain network clustering coefficients were analyzed. The small world attribute value (蟽), global efficiency (Eglob) and local efficiency (Eloc) are compared. Results 蟽 1 non PSD group was significantly higher than PSD group (P 0.05). There were significant differences in Eglob,Eloc,Lp, 位 and Cp, 緯 between the two groups (P0.05). The Cp of the right olfactory cortex in the Non-PSD group was significantly higher than that in the PSD group, the left dorsolateral superior frontal gyrus, the right orbital superior frontal gyrus, the middle frontal gyrus, and the left middle frontal gyrus. The Cp of subfrontal gyrus, left triangular subfrontal gyrus, left medial and accessory cingulate gyrus, right hippocampus, right angular gyrus, left caudate nucleus, left lentiform globus pallidus and left superior temporal gyrus in PSD group were significantly lower than those in PSD group (P0.05). The efficiency of subfrontal gyrus, left medial superior frontal gyrus, left anterior cingulate band and para-cingulate gyrus, right anterior cingulate band and accessory cingulate gyrus, left posterior cingulate gyrus, left hippocampus, right thalamus and right middle temporal gyrus were significantly lower than those in PSD group (P0.05). Conclusion the brain structure and network of PSD patients have small-world properties, Cp changes in some brain regions and nodal efficiency in some brain regions.
【作者單位】： 右江民族醫(yī)學(xué)院臨床學(xué)院;百色市人民醫(yī)院影像科;百色市人民醫(yī)院婦科;右江民族醫(yī)學(xué)院附屬醫(yī)院影像科;
【基金】：國家自然科學(xué)基金(81169146) 廣西壯族自治區(qū)衛(wèi)生和計(jì)劃生育委員會中醫(yī)藥民族醫(yī)藥傳承創(chuàng)新專項(xiàng)課題(GZLC16-49) 廣西高校重點(diǎn)實(shí)驗(yàn)室開放課題(gxzdsysyy2015211)
【分類號】：R743.3;R749.4
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 江擁軍;康濤生;肖雁;;卒中后抑郁119例臨床分析[J];軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào);2010年04期
2 朱建中;周兆新;張恒;;音樂療法對腦卒中后抑郁患者的康復(fù)作用[J];中國康復(fù);2010年06期
3 朱榮彥;楊建芳;許尊貴;許月琨;盧海麗;侯永革;劉翠平;;全程心理干預(yù)對卒中后抑郁的影響[J];臨床薈萃;2011年12期
4 易進(jìn);賀建華;;腦卒中后抑郁的診治[J];臨床藥物治療雜志;2012年02期
5 張疏;羅本燕;;關(guān)注卒中后抑郁的識別與治療[J];中國卒中雜志;2012年10期
6 關(guān)健偉,巫志明,鄒勁;腦卒中后抑郁與康復(fù)[J];湛江醫(yī)學(xué)院學(xué)報(bào);1993年Z1期
7 張志s，
本文編號：2397216
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/2397216.html
[Abstract]:Objective to investigate the changes of brain network topology in (PSD) patients with post-stroke depression. Methods DTI examination was performed in 29 patients with non-PSD stroke (Non-PSD group) and 19 patients with PSD (PSD group). The deterministic fiber tracing method is used to construct the white matter structure network based on partial anisotropy. The topological properties of brain network in two groups of patients were analyzed by using graph theory method, and the normalized clustering coefficients (緯), standard characteristic path lengths (位) of the (Cp), characteristic path length of the two groups of brain network clustering coefficients, and the normalized clustering coefficients (緯), standard characteristic path lengths (位) of the two groups of brain network clustering coefficients were analyzed. The small world attribute value (蟽), global efficiency (Eglob) and local efficiency (Eloc) are compared. Results 蟽 1 non PSD group was significantly higher than PSD group (P 0.05). There were significant differences in Eglob,Eloc,Lp, 位 and Cp, 緯 between the two groups (P0.05). The Cp of the right olfactory cortex in the Non-PSD group was significantly higher than that in the PSD group, the left dorsolateral superior frontal gyrus, the right orbital superior frontal gyrus, the middle frontal gyrus, and the left middle frontal gyrus. The Cp of subfrontal gyrus, left triangular subfrontal gyrus, left medial and accessory cingulate gyrus, right hippocampus, right angular gyrus, left caudate nucleus, left lentiform globus pallidus and left superior temporal gyrus in PSD group were significantly lower than those in PSD group (P0.05). The efficiency of subfrontal gyrus, left medial superior frontal gyrus, left anterior cingulate band and para-cingulate gyrus, right anterior cingulate band and accessory cingulate gyrus, left posterior cingulate gyrus, left hippocampus, right thalamus and right middle temporal gyrus were significantly lower than those in PSD group (P0.05). Conclusion the brain structure and network of PSD patients have small-world properties, Cp changes in some brain regions and nodal efficiency in some brain regions.
【作者單位】： 右江民族醫(yī)學(xué)院臨床學(xué)院;百色市人民醫(yī)院影像科;百色市人民醫(yī)院婦科;右江民族醫(yī)學(xué)院附屬醫(yī)院影像科;
【基金】：國家自然科學(xué)基金(81169146) 廣西壯族自治區(qū)衛(wèi)生和計(jì)劃生育委員會中醫(yī)藥民族醫(yī)藥傳承創(chuàng)新專項(xiàng)課題(GZLC16-49) 廣西高校重點(diǎn)實(shí)驗(yàn)室開放課題(gxzdsysyy2015211)
【分類號】：R743.3;R749.4
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 江擁軍;康濤生;肖雁;;卒中后抑郁119例臨床分析[J];軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào);2010年04期
2 朱建中;周兆新;張恒;;音樂療法對腦卒中后抑郁患者的康復(fù)作用[J];中國康復(fù);2010年06期
3 朱榮彥;楊建芳;許尊貴;許月琨;盧海麗;侯永革;劉翠平;;全程心理干預(yù)對卒中后抑郁的影響[J];臨床薈萃;2011年12期
4 易進(jìn);賀建華;;腦卒中后抑郁的診治[J];臨床藥物治療雜志;2012年02期
5 張疏;羅本燕;;關(guān)注卒中后抑郁的識別與治療[J];中國卒中雜志;2012年10期
6 關(guān)健偉,巫志明,鄒勁;腦卒中后抑郁與康復(fù)[J];湛江醫(yī)學(xué)院學(xué)報(bào);1993年Z1期
7 張志s，
本文編號：2397216
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/2397216.html
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