血清尿酸與大動脈粥樣硬化型缺血性腦卒中的相關(guān)性研究
發(fā)布時間：2018-11-22 12:55
【摘要】：目的： 探討大動脈粥樣硬化型缺血性腦卒中(Large artery atherosclerosis ischemicstroke, LAA)急性期血清尿酸（Serum uric acid, SUA）與其病情嚴重程度、其他相關(guān)危險因素及短期預(yù)后的相關(guān)性，為臨床科學(xué)治療大動脈粥樣硬化型缺血性腦卒中，改善其預(yù)后提供依據(jù)。 方法： 選取2012年12月到2013年12月在發(fā)病1天之內(nèi)入住郴州市第一人民醫(yī)院神經(jīng)內(nèi)科治療并確診的大動脈粥樣硬化型缺血性腦卒中的患者282例作為病例組；對照組為同期門診性別、年齡匹配的282例健康體檢者。病例組及對照組均記錄一般臨床資料（性別、年齡、高血壓、、糖尿病、吸煙、飲酒等）、測定相關(guān)生化指標等，入院后14天或出院時行MRS評分。單因素及Logistic回歸分析大動脈粥樣硬化型缺血性腦卒中急性期血清尿酸與其病情嚴重程度、其他相關(guān)危險因素及短期預(yù)后的相關(guān)性。 結(jié)果： 1、病例組高血壓、糖尿病患病率及吸煙、飲酒史明顯高于對照組（P0.05），病例組SUA、SBP、DBP、TG、LDL、HsCRP、 Fib、BMI較對照組高（P0.05）。 2、單因素方差分析顯示輕度、中度、重度缺血性腦卒中三型之間血清尿酸水平差異有統(tǒng)計學(xué)意義，P0.01。再對不同病情程度的缺血性腦卒中的血清尿酸行兩兩之間的LSD-T檢驗，差異仍有統(tǒng)計學(xué)意義。 3、相關(guān)分析得出在大動脈粥樣性硬化型缺血性腦卒中急性期血清尿酸與SBP、TG、FBG、LDL、HsCRP成正相關(guān)（P0.05）。 4、單因素分析大動脈粥樣性硬化型缺血性腦卒中預(yù)后良好組與預(yù)后不良組，高尿酸血癥、年齡、高血壓、糖尿病、FBG、LDL、HsCRP、BMI、NIHSS(病情嚴重程度)有統(tǒng)計學(xué)意義（P0.05）。logistic逐步回歸分析表明年齡、糖尿病、LDL、HsCRP、病情嚴重程度為預(yù)后不良的危險指標，而高尿酸血癥不能作為預(yù)后不良的獨立的預(yù)測因素。 結(jié)論： 1、大動脈粥樣硬化型缺血性腦卒中急性期血清尿酸與病情嚴重程度相關(guān)，病情越重，，血清尿酸水平越高。 2、大動脈粥樣硬化型缺血型腦卒中急性期血清尿酸與SBP、TG、FBG、LDL、HsCRP成正相關(guān)。 3、急性期血清尿酸不是大動脈粥樣硬化型缺血性腦卒中短期預(yù)后的獨立預(yù)測因素，可能是疾病發(fā)展過程中表現(xiàn)出來的血清學(xué)異常的指標。
[Abstract]:Objective: to investigate the correlation between serum uric acid (Serum uric acid, SUA) and severity, other risk factors and short-term prognosis of (Large artery atherosclerosis ischemicstroke, LAA) in patients with atherosclerotic stroke. To provide a basis for clinical treatment of atherosclerotic ischemic stroke and improve its prognosis. Methods: 282 patients with atherosclerotic ischemic stroke who were admitted to the Department of Neurology of the first people's Hospital of Chenzhou from December 2012 to December 2013 were selected as the case group. The control group consisted of 282 healthy persons who matched the sex and age of outpatient service in the same period. The general clinical data (sex, age, hypertension, diabetes, smoking, alcohol consumption, etc.) were recorded in both the case group and the control group. The MRS scores were measured on the 14th day after admission or at the time of discharge. Univariate and Logistic regression analysis were used to study the correlation between serum uric acid and severity, other risk factors and short-term prognosis in acute stage of atherosclerotic ischemic stroke. Results: 1. The prevalence of hypertension, diabetes, smoking and alcohol consumption in the case group was significantly higher than that in the control group (P0.05), and the SUA,SBP,DBP,TG,LDL,HsCRP, Fib,BMI in the case group was higher than that in the control group (P0.05). 2. Univariate ANOVA showed significant difference in serum uric acid levels among mild, moderate and severe ischemic stroke types (P0.01). The serum uric acid of ischemic stroke with different degree of disease was tested by LSD-T, and the difference was statistically significant. 3, correlation analysis showed that serum uric acid was positively correlated with SBP,TG,FBG,LDL,HsCRP in the acute phase of atherosclerotic ischemic stroke (P0.05). Univariate analysis of good prognosis and poor prognosis of atherosclerotic ischemic stroke, hyperuricemia, age, hypertension, diabetes, FBG,LDL,HsCRP,BMI, NIHSS (severity of disease) was statistically significant (P0.05). Logistic stepwise regression analysis showed that age, diabetes, LDL,HsCRP, severity were the risk indicators of poor prognosis. Hyperuricemia is not an independent predictor of poor prognosis. Conclusion: 1. The serum uric acid level is related to the severity of the disease in the acute phase of atherosclerotic ischemic stroke. The more serious the condition, the higher the serum uric acid level. 2. There was a positive correlation between serum uric acid and SBP,TG,FBG,LDL,HsCRP in acute stage of atherosclerotic cerebral apoplexy. 3. Serum uric acid in acute stage is not an independent predictor of short-term prognosis of atherosclerotic ischemic stroke, and may be an indicator of serological abnormalities in the course of disease development.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743.3
本文編號：2349435
[Abstract]:Objective: to investigate the correlation between serum uric acid (Serum uric acid, SUA) and severity, other risk factors and short-term prognosis of (Large artery atherosclerosis ischemicstroke, LAA) in patients with atherosclerotic stroke. To provide a basis for clinical treatment of atherosclerotic ischemic stroke and improve its prognosis. Methods: 282 patients with atherosclerotic ischemic stroke who were admitted to the Department of Neurology of the first people's Hospital of Chenzhou from December 2012 to December 2013 were selected as the case group. The control group consisted of 282 healthy persons who matched the sex and age of outpatient service in the same period. The general clinical data (sex, age, hypertension, diabetes, smoking, alcohol consumption, etc.) were recorded in both the case group and the control group. The MRS scores were measured on the 14th day after admission or at the time of discharge. Univariate and Logistic regression analysis were used to study the correlation between serum uric acid and severity, other risk factors and short-term prognosis in acute stage of atherosclerotic ischemic stroke. Results: 1. The prevalence of hypertension, diabetes, smoking and alcohol consumption in the case group was significantly higher than that in the control group (P0.05), and the SUA,SBP,DBP,TG,LDL,HsCRP, Fib,BMI in the case group was higher than that in the control group (P0.05). 2. Univariate ANOVA showed significant difference in serum uric acid levels among mild, moderate and severe ischemic stroke types (P0.01). The serum uric acid of ischemic stroke with different degree of disease was tested by LSD-T, and the difference was statistically significant. 3, correlation analysis showed that serum uric acid was positively correlated with SBP,TG,FBG,LDL,HsCRP in the acute phase of atherosclerotic ischemic stroke (P0.05). Univariate analysis of good prognosis and poor prognosis of atherosclerotic ischemic stroke, hyperuricemia, age, hypertension, diabetes, FBG,LDL,HsCRP,BMI, NIHSS (severity of disease) was statistically significant (P0.05). Logistic stepwise regression analysis showed that age, diabetes, LDL,HsCRP, severity were the risk indicators of poor prognosis. Hyperuricemia is not an independent predictor of poor prognosis. Conclusion: 1. The serum uric acid level is related to the severity of the disease in the acute phase of atherosclerotic ischemic stroke. The more serious the condition, the higher the serum uric acid level. 2. There was a positive correlation between serum uric acid and SBP,TG,FBG,LDL,HsCRP in acute stage of atherosclerotic cerebral apoplexy. 3. Serum uric acid in acute stage is not an independent predictor of short-term prognosis of atherosclerotic ischemic stroke, and may be an indicator of serological abnormalities in the course of disease development.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743.3
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