【摘要】：目的:觀察強化訓(xùn)練與預(yù)防性抗抑郁治療對腦卒中患者的運動功能及抑郁狀態(tài)的影響方法:采用隨機數(shù)字表將45例腦卒中患者(均未診斷卒中后抑郁)分為單純治療組、強化訓(xùn)練組以及強化訓(xùn)練+預(yù)防性抗抑郁治療組,每組各15例。3組患者皆給予常規(guī)腦卒中藥物治療及康復(fù)訓(xùn)練,強化訓(xùn)練組在此基礎(chǔ)上每日增加1次運動功能訓(xùn)練。強化訓(xùn)練+預(yù)防性抗抑郁治療組在在每日增加1次運動功能訓(xùn)練的同時,進一步給予預(yù)防性抗抑郁藥物治療。分別于治療前、治療2周后以及治療4周后采集改良Barthel指數(shù)評定量表(MBI)、Fugl-Meyer運動功能評分(FMA)、抑郁自評量表(Self-rating depression scale,SDS)對患者的運動功能、生活自理能力、抑郁狀態(tài)進行評估。結(jié)果:治療前,三組患者在Barthel、FMA和抑郁指數(shù)三方面均無顯著差異,治療后強化訓(xùn)練組與強化訓(xùn)練+預(yù)防性抗抑郁治療組分別比較單純治療組的Barthel指數(shù)及FMA評分均有顯著差異,2組的ADL和FMA評分均高于單純治療組(P0.05)。強化訓(xùn)練+預(yù)防性抗抑郁治療組與強化訓(xùn)練組相比,其Barthel指數(shù)、FMA評分差異沒有統(tǒng)計學(xué)意義。三組的SDS評分在三組組間與治療前后(組內(nèi))對比均無符合統(tǒng)計學(xué)意義。結(jié)論:強化運動訓(xùn)練治療能有效改善腦卒中患者的整體預(yù)后表現(xiàn),提高臨床康復(fù)效果。接受預(yù)防性抗抑郁治療患者的運動功能恢復(fù)以及對卒中后抑郁的發(fā)病率的影響與未接受預(yù)防性抗抑郁治療的患者相比差異無統(tǒng)計學(xué)意義。本實驗的患者在實驗前后均未出現(xiàn)卒中后抑郁癥,考慮此次實驗存在樣本量少、觀察的時間較短等因素,目前尚不能得出預(yù)防性抗抑郁治療無效的結(jié)論。
[Abstract]:Objective: to observe the effect of intensive training and prophylactic antidepressant therapy on motor function and depression state of stroke patients. Intensive training group and preventive antidepressant treatment group, 15 cases in each group. 3 groups of patients were given routine stroke drug treatment and rehabilitation training, intensive training group on the basis of daily exercise function training. Intensive training preventive antidepressant treatment group was treated with prophylactic antidepressant while increasing exercise function training once a day. Before, 2 weeks and 4 weeks after treatment, the motor function scores of modified Barthel index rating scale (MBI), Fugl-Meyer), motor function scale (FMA),) and self-rating depression scale (Self-rating depression scale,SDS) were collected to evaluate the motor function of the patients. Self-care ability and depression were evaluated. Results: before treatment, there was no significant difference in Barthel,FMA and depressive index among the three groups. There were significant differences in Barthel index and FMA score between the intensive training group and the preventive antidepressant group after treatment. The ADL and FMA scores in both groups were higher than those in the control group (P 0.05). There was no significant difference in Barthel index and FMA score between intensive training preventive antidepressant therapy group and intensive training group. The SDS scores of the three groups were not statistically significant between the three groups and before and after treatment. Conclusion: intensive exercise training can effectively improve the overall prognosis of stroke patients and improve the clinical rehabilitation effect. There was no significant difference in the recovery of motor function and the incidence of post-stroke depression in patients receiving prophylactic antidepressant therapy as compared with those who did not receive preventive antidepressant therapy. There was no post-stroke depression in the patients before and after the experiment. Considering the small sample size and short observation time, it is not possible to draw the conclusion that preventive antidepressant treatment is ineffective.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R743.3

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