帕金森病與血管性帕金森綜合征患者血清炎癥因子的相關(guān)性分析
發(fā)布時(shí)間：2018-08-29 16:12
【摘要】：目的:通過檢測(cè)帕金森(Parkinson's disease,PD)及血管性帕金森綜合征(Vascular parkinsonism,VP)患者外周血清白介素6及白介素32水平,進(jìn)一步了解炎癥因子與患者臨床癥狀的相關(guān)性。方法:采用橫斷面研究,選取2014年10月至2016年10月之間我院門診及住院部PD患者64例及VP患者48例,對(duì)入組患者進(jìn)行量表評(píng)分(UPDRSIII統(tǒng)一帕金森評(píng)分量表評(píng)分、Hoehn-Yahr分級(jí)量表、NMSS帕金森非運(yùn)動(dòng)障礙評(píng)價(jià)量表及MMSE簡(jiǎn)易智能精神狀態(tài)檢查量表)。同時(shí)收集河南科技大學(xué)健康體檢中心中老年體檢者60例。采用ELISA法檢測(cè)患者及健康體檢者外周血清中白介素6及白介素32水平。采用SPSS 21.0軟件對(duì)對(duì)比分析帕金森與血管性帕金森綜合征患者兩種炎癥因子與各量表評(píng)分的相關(guān)性,P0.05有統(tǒng)計(jì)學(xué)意義。結(jié)果:1.VP患者的發(fā)病年齡大于PD患者的發(fā)病年齡(F=32.452,P=0.000);VP患者左旋多巴用量高于PD患者(t=2.792,P=0.006);與PD患者相比,VP患者更易出現(xiàn)智能損害(t=2.920,P=0.004);2.PD患者血清白介素6水平顯著高于VP患者(P=0.005),且兩組患者血清白介素6水平顯著高于對(duì)照組(P=0.000);VP患者血清白介素32水平顯著高于PD患者,且均顯著高于對(duì)照組(P=0.000);3.PD患者的病程與運(yùn)動(dòng)癥狀評(píng)分及左旋多巴用量呈正相關(guān);4.VP患者病程與患者運(yùn)動(dòng)等級(jí)及智能狀態(tài)成正相關(guān);5.白介素32水平與PD患者NMSS評(píng)分存在正相關(guān)關(guān)系(r=0.690,P=0.000);6.白介素32水平與VP患者UPDRSIII評(píng)分(r=0.511,P=0.000)及Hoehn-Yahr評(píng)分(r=0.602,P=0.000)呈正相關(guān)。結(jié)論:1.兩組患者白介素6及白介素32均顯著高于對(duì)照組;2.白介素6與PD患者及VP患者的臨床癥狀均無關(guān),白介素32與PD患者的非運(yùn)動(dòng)癥狀及VP患者的運(yùn)動(dòng)癥狀均有顯著正相關(guān)。
[Abstract]:Aim: to investigate the relationship between inflammatory factors and clinical symptoms in patients with Parkinson's disease (Parkinson's disease,PD) and vascular Parkinson's syndrome (Vascular parkinsonism,VP) by detecting the levels of interleukin 6 and interleukin 32 in peripheral blood. Methods: from October 2014 to October 2016, 64 patients with PD and 48 patients with VP were selected by cross-sectional study. The patients were assessed with the UPDRSIII Unified Parkinson's scale (UPDRSIII), including the Hoehn-Yahr scale, the NMSS Parkinson's Non-motor Disorder scale and the MMSE's Mini-Mental State scale. At the same time, we collected 60 cases of middle and old people in the health examination center of Henan University of Science and Technology. The levels of interleukin 6 and interleukin 32 in peripheral serum of patients and healthy persons were detected by ELISA method. SPSS 21.0 software was used to compare and analyze the correlation between the two inflammatory factors and the scores of each scale in patients with Parkinson's syndrome and vascular Parkinson's syndrome (P 0.05). Results: 1. The onset age of VP patients was greater than that of PD patients (F = 32.452P 0.000). The dosage of levodopa in patients with VP was higher than that in patients with PD (t = 2.792 P0. 006). Compared with PD patients, patients with VP were more likely to suffer from intellectual impairment (tn 2.920 P0. 004). 2. The level of interleukin 6 in patients with PD was significantly higher than that in patients with VP. (2) the level of serum interleukin 6 in patients with PD was significantly higher than that in patients with VP. The level of serum interleukin 6 in the two groups was significantly higher than that in the control group (P < 0. 000). The serum level of interleukin 32 in the patients with VP was significantly higher than that in the patients with PD. The course of disease was significantly higher than that of the control group (P0. 000). 3. There was a positive correlation between the course of disease and the score of motor symptom and the dosage of levodopa. 4. There was a positive correlation between the course of disease and the motor grade and intelligence state of the patients with VP. There was a positive correlation between the level of IL 32 and the NMSS score of PD patients (r 0. 690 P 0. 000). The level of interleukin 32 was positively correlated with the UPDRSIII score (r = 0.511) and the Hoehn-Yahr score (r = 0.602) in patients with VP. Conclusion 1. The levels of IL 6 and IL 32 in the two groups were significantly higher than those in the control group. Interleukin-6 was not associated with the clinical symptoms of PD patients and VP patients. Interleukin-32 was positively correlated with non-motor symptoms in PD patients and sports symptoms in VP patients.
【學(xué)位授予單位】：河南科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R742.5
本文編號(hào)：2211724
[Abstract]:Aim: to investigate the relationship between inflammatory factors and clinical symptoms in patients with Parkinson's disease (Parkinson's disease,PD) and vascular Parkinson's syndrome (Vascular parkinsonism,VP) by detecting the levels of interleukin 6 and interleukin 32 in peripheral blood. Methods: from October 2014 to October 2016, 64 patients with PD and 48 patients with VP were selected by cross-sectional study. The patients were assessed with the UPDRSIII Unified Parkinson's scale (UPDRSIII), including the Hoehn-Yahr scale, the NMSS Parkinson's Non-motor Disorder scale and the MMSE's Mini-Mental State scale. At the same time, we collected 60 cases of middle and old people in the health examination center of Henan University of Science and Technology. The levels of interleukin 6 and interleukin 32 in peripheral serum of patients and healthy persons were detected by ELISA method. SPSS 21.0 software was used to compare and analyze the correlation between the two inflammatory factors and the scores of each scale in patients with Parkinson's syndrome and vascular Parkinson's syndrome (P 0.05). Results: 1. The onset age of VP patients was greater than that of PD patients (F = 32.452P 0.000). The dosage of levodopa in patients with VP was higher than that in patients with PD (t = 2.792 P0. 006). Compared with PD patients, patients with VP were more likely to suffer from intellectual impairment (tn 2.920 P0. 004). 2. The level of interleukin 6 in patients with PD was significantly higher than that in patients with VP. (2) the level of serum interleukin 6 in patients with PD was significantly higher than that in patients with VP. The level of serum interleukin 6 in the two groups was significantly higher than that in the control group (P < 0. 000). The serum level of interleukin 32 in the patients with VP was significantly higher than that in the patients with PD. The course of disease was significantly higher than that of the control group (P0. 000). 3. There was a positive correlation between the course of disease and the score of motor symptom and the dosage of levodopa. 4. There was a positive correlation between the course of disease and the motor grade and intelligence state of the patients with VP. There was a positive correlation between the level of IL 32 and the NMSS score of PD patients (r 0. 690 P 0. 000). The level of interleukin 32 was positively correlated with the UPDRSIII score (r = 0.511) and the Hoehn-Yahr score (r = 0.602) in patients with VP. Conclusion 1. The levels of IL 6 and IL 32 in the two groups were significantly higher than those in the control group. Interleukin-6 was not associated with the clinical symptoms of PD patients and VP patients. Interleukin-32 was positively correlated with non-motor symptoms in PD patients and sports symptoms in VP patients.
【學(xué)位授予單位】：河南科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R742.5
【參考文獻(xiàn)】
相關(guān)期刊論文 前8條
1 張薇;;老年血管性帕金森綜合征和帕金森病患者智能損害對(duì)比研究及其臨床意義[J];疾病監(jiān)測(cè)與控制;2016年12期
2 任思思;萬麗;傅啟會(huì);何雄偉;;吸煙與帕金森病患病風(fēng)險(xiǎn)的Meta分析[J];中國(guó)醫(yī)藥導(dǎo)報(bào);2016年14期
3 劉宇翔;尹邦良;劉振華;;中國(guó)帕金森病患者的經(jīng)濟(jì)負(fù)擔(dān)及相關(guān)因素調(diào)查研究[J];中國(guó)現(xiàn)代醫(yī)學(xué)雜志;2016年08期
4 尚俊奎;陳帥;樊曉蕊;張杰文;;血管性帕金森綜合征研究進(jìn)展[J];國(guó)際神經(jīng)病學(xué)神經(jīng)外科學(xué)雜志;2013年Z1期
5 王遙;殷實(shí);劉衛(wèi)國(guó);卞鷹;王寶明;葉民;林興建;張麗;;帕金森病患者疾病的經(jīng)濟(jì)負(fù)擔(dān)及其相關(guān)影響因素研究[J];臨床神經(jīng)病學(xué)雜志;2011年06期
6 趙德強(qiáng);血管性帕金森綜合征與帕金森病臨床特點(diǎn)及影像學(xué)的對(duì)比研究[J];第一軍醫(yī)大學(xué)學(xué)報(bào);2005年07期
7 Roman G.C.;黃衛(wèi)東;;北京、西安和上海地區(qū)帕金森病的流行病學(xué)調(diào)查[J];世界核心醫(yī)學(xué)期刊文摘(神經(jīng)病學(xué)分冊(cè));2005年07期
8 董建群,張清華,蔣知新,衣志勇,喻陸,李禎華,張艷琴,方明俊,張振馨,張孔來;吸煙與帕金森病關(guān)系的病例對(duì)照研究[J];中華流行病學(xué)雜志;2003年07期
，本文編號(hào)：2211724
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