【摘要】：目的采用靜息態(tài)f MRI基于體素鏡像同倫連接(VMHC)方法觀察偏側帕金森病老年患者的腦半球間連接功能改變情況,探討其可能的病理生理機制。方法收集24例老年原發(fā)性偏側帕金森患者,根據(jù)發(fā)病側分為左側發(fā)病組(11例)和右側發(fā)病組(13例)。收集性別、年齡相匹配的15名健康自愿者為對照組。采集靜息態(tài)f MRI數(shù)據(jù),在Matlab7.8平臺上進行預處理,計算出三組VMHC改變的腦區(qū),進行相關性分析。結果三組受試者丘腦、舌回、額中及下回、緣上回、額上回、中央前及后回的VMHC值之間差異均有統(tǒng)計學意義(P0.05)。左側發(fā)病組患者丘腦半球VMHC值明顯高于對照組;在視覺皮層、感覺運動皮層、其他腦區(qū)(頂下小葉、中央旁小葉、下半月小葉、小腦后葉)的VMHC值明顯低于對照組(P0.05)。右側發(fā)病組患者在前額葉、感覺運動皮層VMHC值明顯低于對照組;在丘腦、蒼白球、額上回VMHC值明顯高于對照組(P0.05)。左側發(fā)病組患者在視覺皮層、感覺運動皮層VMHC值明顯低于對照組;在緣上回VMHC值明顯高于對照組(P0.05)。左側發(fā)病組,枕中回和中央后回的VMHC水平與BDI-Ⅱ評分呈負相關,與MMSE評分呈正相關。右側發(fā)病組,緣上回VMHC水平與病程呈正相關,中后回的VMHC水平與MMSE評分呈正相關。結論老年帕金森患者運動癥狀偏側性影響到腦半球間的功能連接模式,可能是偏側帕金森病的病理生理機制之一。
[Abstract]:Objective to observe the changes of interhemispheric junction function in elderly patients with hemispheric Parkinson's disease using resting f MRI based on voxel mirror homotopy connection (VMHC) and to explore its possible pathophysiological mechanism. Methods 24 elderly patients with primary parkinsonism were divided into left side group (11 cases) and right side group (13 cases). Fifteen healthy volunteers matched for gender and age were collected as control group. The rest f MRI data were collected and preprocessed on the Matlab7.8 platform. Three groups of brain regions changed by VMHC were calculated and the correlation analysis was carried out. Results the VMHC values of thalamus, lingual gyrus, middle and inferior frontal gyrus, supramarginal gyrus, suprafrontal gyrus, precentral gyrus and postcentral gyrus were significantly different among the three groups (P0.05). The VMHC value of thalamic hemisphere in the left group was significantly higher than that in the control group, and the VMHC value in the visual cortex, sensorimotor cortex and other brain regions (inferior parietal lobules, paracentral lobules, lower semilunar lobules, posterior cerebellar lobes) was significantly lower than that in the control group (P0.05). In the right group, the VMHC value of the sensory motor cortex was significantly lower than that of the control group in the prefrontal lobe, and the VMHC value in the thalamus, globus pallidus and superior frontal gyrus was significantly higher than that in the control group (P0.05). The VMHC value of sensory motor cortex in the left group was significantly lower than that of the control group, and the VMHC value in the superior marginal gyrus was significantly higher than that in the control group (P0.05). In the left group, the levels of VMHC in the middle occipital gyrus and postcentral gyrus were negatively correlated with BDI- 鈪，

本文編號：2197587