【摘要】：目的探討尤瑞克林聯(lián)合阿司匹林治療急性腦梗死的作用機(jī)制。方法選取86例急性腦梗死患者,隨機(jī)分為觀察組(n=43)和對(duì)照組(n=43),在常規(guī)治療基礎(chǔ)上,觀察組予尤瑞克林及阿司匹林治療,對(duì)照組僅予阿司匹林,治療后2周比較兩組患者血液流變學(xué)、同型半胱氨酸(Hcy)、高敏C反應(yīng)蛋白(hs-CRP)、血管內(nèi)皮生長(zhǎng)因子(VEGF)、胱抑素(Cys)-C、白介素(IL)-6、神經(jīng)功能缺損(NIHSS)及日常生活能力(ADL)等。結(jié)果觀察組血清Hcy、hs-CRP、VEGF、Cys-C、IL-6、NIHSS、ADL均優(yōu)于對(duì)照組(P0.05);觀察組臨床療效明顯比對(duì)照組高[95.35%(41/43)vs 74.42%(32/43)](P0.05)。結(jié)論在急性腦梗死患者中應(yīng)用尤瑞克林聯(lián)合阿司匹林效果顯著,其內(nèi)在機(jī)制可能和早期改善血清Hcy、hs-CRP、VEGF、Cys-C、IL-6的表達(dá)相關(guān)。
[Abstract]:Objective to investigate the mechanism of Urethrin combined with aspirin in the treatment of acute cerebral infarction. Methods Eighty-six patients with acute cerebral infarction were randomly divided into two groups: observation group (n = 43) and control group (n = 43). On the basis of routine treatment, the observation group was treated with eucrine and aspirin, while the control group was treated with aspirin only. Hemorheology, homocysteine (Hcy), Gao Min C-reactive protein (hs-CRP), vascular endothelial growth factor (VEGF-VEGF), cystatin (Cys) -C, interleukin-6 (IL-6), neurologic impairment (NIHSS) and activities of daily living (ADL) were compared between the two groups two weeks after treatment. Results the serum levels of Hcyhs-CRP- VEGFN Cys-Csil / NIHSSN ADL in the observation group were significantly higher than those in the control group (P0.05), and the clinical efficacy in the observation group was significantly higher than that in the control group [95.35% (41 / 43) vs 74.42% (32 / 43)] (P0.05). Conclusion Urethrin combined with aspirin is effective in patients with acute cerebral infarction, and its intrinsic mechanism may be related to the early improvement of serum Hcyhs-CRP VEGF Cys-Cn IL-6 expression.
【作者單位】： 廣東省東莞市第三人民醫(yī)院神經(jīng)內(nèi)科;
【基金】：廣東省東莞市醫(yī)療衛(wèi)生科技計(jì)劃一般項(xiàng)目(編號(hào):2015105101081)
【分類號(hào)】：R743.3

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