發(fā)布時(shí)間：2018-07-10 15:01

  本文選題：氯吡格雷 + 阿司匹林��； 參考：《中國藥房》2016年27期

【摘要】：目的:觀察氯吡格雷聯(lián)合阿司匹林治療老年短暫性腦缺血發(fā)作的療效和安全性。方法:90例短暫性腦缺血發(fā)作老年患者隨機(jī)分為觀察組(50例)和對(duì)照組(40例)。兩組患者均予以缺血性腦卒中患者常規(guī)治療,包括他汀類藥物、低分子右旋糖酐、尿激酶等藥物,對(duì)于合并其他基礎(chǔ)疾病者給予對(duì)癥治療。在此基礎(chǔ)上,對(duì)照組患者口服阿司匹林腸溶片100 mg,每日1次;觀察組患者在對(duì)照組治療的基礎(chǔ)上口服硫酸氫氯吡格雷片75 mg,每日1次。兩組均需避免服用其他種類抗血小板藥。兩組均連續(xù)治療6個(gè)月。觀察兩組患者的臨床療效,治療前后血小板功能指標(biāo)(CD63、CD62p),隨訪治療6個(gè)月后的復(fù)發(fā)率及腦卒中發(fā)生率,記錄不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患者總有效率顯著高于對(duì)照組,復(fù)發(fā)率及腦卒中發(fā)生率均顯著低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者CD63、CD62p水平均顯著低于同組治療前,且觀察組低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者治療期間均未見明顯不良反應(yīng)發(fā)生。結(jié)論:在常規(guī)治療的基礎(chǔ)上,氯吡格雷聯(lián)合阿司匹林治療老年短暫性腦缺血發(fā)作的療效優(yōu)于單用阿司匹林,可降低其復(fù)發(fā)率和腦卒中發(fā)生率,且安全性較好。
[Abstract]:Objective: to observe the efficacy and safety of clopidogrel combined with aspirin in the treatment of senile transient ischemic attack. Methods 90 elderly patients with TIA were randomly divided into observation group (n = 50) and control group (n = 40). Both groups were given routine treatment for ischemic stroke patients, including statins, low molecular weight dextran, urokinase and other drugs. On this basis, the control group took 100 mg aspirin enteric coated tablets once a day, while the patients in the observation group took 75 mg hydroclopidogrel sulfate once a day on the basis of the treatment in the control group. Both groups should avoid taking other antiplatelet drugs. Both groups were treated continuously for 6 months. The clinical efficacy, platelet function index (CD63, CD62P), recurrence rate and stroke incidence after 6 months follow-up were observed, and adverse reactions were recorded. Results: the total effective rate in the observation group was significantly higher than that in the control group. The recurrence rate and the incidence of stroke were significantly lower in the observation group than in the control group (P0.05). After treatment, the levels of CD63P CD62P in the two groups were significantly lower than those in the same group before treatment, and the observation group was lower than the control group, the difference was statistically significant (P0.05). No significant adverse reactions occurred during treatment in both groups. Conclusion: on the basis of routine therapy, clopidogrel combined with aspirin is more effective than aspirin alone in the treatment of elderly transient ischemic attack, which can reduce the recurrence rate and the incidence of stroke, and the safety of clopidogrel combined with aspirin is better than that of aspirin alone.
【作者單位】： 南陽市第三人民醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R743.31

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