本文選題：腦梗死 + 動脈粥樣硬化斑塊��； 參考：《新鄉(xiāng)醫(yī)學院》2014年碩士論文

【摘要】：目的通過系統(tǒng)全面的臨床試驗觀察,研究瑞舒伐他汀聯(lián)合銀沓葉片對腦梗死患者頸動脈粥樣硬化斑塊及血脂異常的影響。方法選取新鄉(xiāng)醫(yī)學院第三附屬醫(yī)院神經(jīng)內科2013.09-2014.01符合納入標準的患者56例,運用隨機數(shù)字表的方法將56例病人分為兩組,其中治療組28例：睡前頓服瑞舒伐他汀10mg,合用銀杏葉片,每同3次,每次1片；對照組28例：睡前頓服瑞舒伐他汀10mg。本研究觀察時限6個月。運用頸動脈多普勒超聲分別于治療前后檢測頸動脈內膜-中膜厚度(IMT)及頸動脈粥樣硬化斑塊,計算斑塊面積和斑塊總積分；運用全自動生化分析儀檢測甘油三酯(TC)、總膽固醇(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)水平。治療期間需對藥物的不良反應進行觀察。結果治療前,對照組及治療組頸動詠IMT、斑塊面積、斑塊總積分、TC、TG、LDL-C、 HDL-C比較(P0.05),差異無統(tǒng)計學意義。6個月療程結束后,與治療前相比,對照組及治療組頸動脈IMT、斑塊面積、斑塊總積分及TC、TG、LDL-C均降低(P0.05),HDL-C升高(P0.05),差異有統(tǒng)計學意義；與對照組比,治療組斑塊IMT、斑塊面積水平、斑塊總積分及TC、TG、LDL-C降低,HDL-C升高(P0.05),差異有統(tǒng)計學意義。結論 1、瑞舒伐他汀可有效地逆轉頸動脈粥樣硬化斑塊的形成,可以縮小斑塊IMT值、斑塊總積分及斑塊面積,降低血脂。2、瑞舒伐他汀聯(lián)合銀含葉片能更好地逆轉腦梗死患者頸動脈粥樣硬化斑塊的形成,可以縮小斑塊IMT值、斑塊總積分及斑塊面積,且較單用瑞舒伐他汀組療效更明顯。 3、瑞舒伐他汀聯(lián)合銀杏葉對腦梗死患者的血脂水平有明顯改善,即降低TC、TG、LDL-C,升高HDL-C,且較單用瑞舒伐他汀組療效更明顯。
[Abstract]:Objective to study the effects of rosuvastatin combined with silverleaf on carotid atherosclerotic plaque and dyslipidemia in patients with cerebral infarction. Methods Fifty-six patients in Department of Neurology, the third affiliated Hospital of Xinxiang Medical College, were selected and divided into two groups by random digital table method: the treatment group (n = 28) received resuvastatin 10mg before bedtime, combined with ginkgo biloba leaf. The control group (n = 28) was treated with rosuvastatin 10 mg before bedtime. The time limit of observation was 6 months. Carotid artery intima-media thickness (IMT) and carotid atherosclerotic plaque were measured by carotid Doppler ultrasound before and after treatment. Plaque area and total plaque score were calculated. The levels of triglyceride (TC), total cholesterol (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured by automatic biochemical analyzer. Adverse drug reactions should be observed during treatment. Results before treatment, there was no significant difference in IMT, plaque area, total plaque score, TGG LDL-C and HDL-C between the control group and the treatment group before treatment (P0.05). After 6 months of treatment, the carotid artery IMT and plaque area in the control group and the treatment group were compared with those before treatment. Compared with the control group, the plaque IMT, plaque area level, plaque total score and TCTGG LDL-C decreased in the treatment group (P0.05), the difference was statistically significant. Conclusion 1. Rosuvastatin can effectively reverse the formation of carotid atherosclerotic plaque, reduce the plaque IMT, total plaque score and plaque area. Reducing blood lipids. 2. The combination of rusuvastatin and silver leaves could reverse the formation of carotid atherosclerotic plaques in patients with cerebral infarction, reduce the IMT value of plaque, the total score of plaque and the area of plaque, and the curative effect was more obvious than that in the group treated with rosuvastatin alone. 3. The serum lipids of patients with cerebral infarction were significantly improved by Risuvastatin combined with ginkgo biloba, that is to say, the level of serum lipids decreased and HDL-C was increased in TCU TGG LDL-C group, and the curative effect was more obvious than that in Risuvastatin alone group.
【學位授予單位】：新鄉(xiāng)醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R743.3
，

本文編號：2080871