本文選題：帕金森病 + 臨床特征��； 參考：《重慶醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：探討帕金森�。≒D）患者臨床特征，如病情嚴(yán)重程度病程發(fā)病年齡臨床類型及每日左旋多巴等效劑量等，與血脂和血尿酸水平的相關(guān)性，觀察其與帕金森病患者的發(fā)病風(fēng)險以及病情進展的預(yù)測之間的關(guān)系，為臨床指導(dǎo)帕金森病患者的飲食和生活方式提供實驗依據(jù) 方法：回顧性統(tǒng)計分析我院130名帕金森病住院患者的臨床資料，分析H-Y分級與起病年齡性別病程的關(guān)系；同時比較帕金森病患者與135名非帕金森病人群的血脂（TC TG LDL HDL ApoA1ApoA1/HDL）以及血尿酸水平的差異性；并分析帕金森病患者多巴胺能藥物替代治療（DRT）的每日左旋多巴等效劑量（LEDD）對血脂血尿酸的影響；此外還比較帕金森病的不同臨床類型（震顫為主型強直-遲緩為主型混合型）之間血脂和血尿酸有無差異性，以及帕金森病患者H-Y分級病程和發(fā)病年齡與血脂血尿酸的相關(guān)性 結(jié)果：130例帕金森病患者平均年齡65.93±10.40歲，男女比例為1.13:1平均起病年齡61.43±10.83歲，平均病程4.5±4.1年，，平均H-Y分級2.28級，平均LEDD為37.5mg其中震顫型28例，強直遲緩型44例，混合型58例，帕金森病患者H-Y分級與年齡病程及LEDD呈正相關(guān)，與病程相關(guān)性最明顯PD組與對照組相比，血尿酸TC TG LDL及ApoA1/HDL差異具有統(tǒng)計學(xué)意義PD震顫型與混合型的LDL水平有統(tǒng)計學(xué)差異（P＜0.05）， PD強直-遲緩型與震顫型ApoA1/HDL有統(tǒng)計學(xué)差異（P＜0.05）帕金森病患者ApoA1/HDL值與H-Y分級呈負(fù)相關(guān)（P＜0.05），而與病程及發(fā)病年齡無相關(guān)性帕金森病患者多巴胺能藥物治療劑量與血脂血尿酸無相關(guān)性（P＞0.05） 結(jié)論： 1PD患者病情嚴(yán)重程度與患者年齡病程以及每日左旋多巴劑量呈正相關(guān)，與病程相關(guān)性最明顯，說明隨著患者患病時間的延長，病情越來越重，符合帕金森病慢性進行性變性加重的特點 2PD患者TC TG LDL ApoA1/HDL及血尿酸水平均較非帕金森病人群低，說明低血脂和血尿酸水平可能是帕金森病發(fā)病的風(fēng)險因素； 3帕金森病不同臨床類型間LDL及ApoA1/HDL比值存在差異； 4帕金森病H-Y分級與ApoA1/HDL呈負(fù)相關(guān)，表明ApoA1/HDL比值越低，則PD患者病情越重； 5每日左旋多巴等效劑量與血脂血尿酸無相關(guān)性，說明多巴胺能藥物替代治療不影響PD患者血脂血尿酸水平
[Abstract]:Objective: to investigate the clinical characteristics of Parkinson's disease (PD), such as the severity of the disease, the age of onset and the daily levodopa equivalent dose, and the correlation with blood lipid and uric acid level. To observe its relationship with the risk of Parkinson's disease and the prediction of disease progression. Methods: the clinical data of 130 patients with Parkinson's disease were analyzed retrospectively and the relationship between H-Y grading and onset age and course of disease was analyzed. Blood lipid (TC TG LDL LDL ApoA 1 / HDL) and serum uric acid levels were compared between patients with Parkinson's disease and 135 patients without Parkinson's disease. The effects of daily levodopa equivalent dose (LEDD) of dopaminergic replacement therapy (DRT) on serum lipids and uric acid were analyzed in patients with Parkinson's disease. In addition, the differences of blood lipids and uric acid among different clinical types of Parkinson's disease (tremor dominated ankylosing and slow mixed type) were also compared. Results the average age of 130 patients with Parkinson's disease was 65.93 鹵10.40 years old, the average onset age was 1.13: 1 鹵10.83 years, the mean course of disease was 4.5 鹵4.1 years. The mean H-Y grade was 2.28, the mean LEDD was 37.5mg, including 28 cases of tremor type, 44 cases of ankylosis retardation type, 58 cases of mixed type. The H-Y grade of Parkinson's disease patients was positively correlated with age course and LEDD, and the most obvious correlation between PD group and control group. Serum uric acid TC TG LDL and ApoA 1 / HDL there were significant differences in LDL levels between PD tremor type and mixed type (P < 0.05), and there was statistical difference between PD ankyle-tardy type and tremor type ApoA 1 / HDL (P < 0.05) in Parkinson's disease patients with ApoA _ 1 / HDL and H-Y score. There was no correlation between the dosage of dopaminergic drugs and serum lipids and uric acid (P > 0.05) in patients with Parkinson's disease (P > 0.05). Conclusion: 1the severity of PD patients is not related to the severity of the disease. The degree was positively correlated with age course and daily levodopa dose. The most significant correlation with the course of disease shows that with the prolongation of the patient's illness time, the disease becomes more and more serious. 2in PD patients, TC TG LDL ApoA 1 / HDL and serum uric acid levels were lower than those in non-Parkinson 's disease group, indicating that hypolipidemia and serum uric acid level may be risk factors of Parkinson's disease. (3) there were differences in LDL and ApoA1 / HDL ratio among different clinical types of Parkinson's disease, and (4) H-Y grade of Parkinson's disease was negatively correlated with ApoA1 / HDL, indicating that the lower the ratio of ApoA1 / HDL, the more serious the disease in PD patients. 5 there was no correlation between daily levodopa equivalent dose and serum lipids and uric acid, indicating that dopaminergic drug replacement therapy had no effect on serum lipids and uric acid levels in PD patients.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R742.5

【共引文獻】

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1 李睿;楊文明;汪美霞;;帕金森病早期診斷線索探討[J];中醫(yī)藥臨床雜志;2013年11期

2 邱菊;杜靜;饒靜;高宗良;;帕金森病患者血清尿酸水平與臨床癥狀的相關(guān)性研究[J];安徽醫(yī)學(xué);2014年08期

3 鐘玲;雷朋;魯鳳嬌;陳亞蘭;彭國光;;帕金森病臨床特征與血脂和血尿酸水平的相關(guān)性分析[J];第三軍醫(yī)大學(xué)學(xué)報;2014年18期

4 顧曉蘇;沈麗華;曹林;周永;;普拉克索治療早期帕金森疾病的效果綜合評價[J];交通醫(yī)學(xué);2013年04期

5 梁晉川;胡小吾;周曉平;陳劍春;郝斌;吳曦;陳鑫;劉建民;;丘腦底核腦深部刺激治療對帕金森病非運動癥狀的影響隊列研究[J];立體定向和功能性神經(jīng)外科雜志;2013年04期

6 劉平;張寶和;徐洪濤;陳彪;;帕金森病運動前期非運動癥狀的認(rèn)識現(xiàn)狀及其在早期診斷中的價值[J];轉(zhuǎn)化醫(yī)學(xué)雜志;2013年06期

7 張小培;;帕金森病非運動癥狀護理干預(yù)38例[J];交通醫(yī)學(xué);2014年01期

8 劉宇慶;關(guān)淑風(fēng);;新疆地區(qū)維、漢族帕金森病患者運動癥狀和非運動癥狀的特點[J];臨床神經(jīng)病學(xué)雜志;2014年02期

9 楊芬;張英謙;呂強;陳雪濤;張衛(wèi)清;王Y

本文編號：2080770