本文選題：內(nèi)臟脂肪素 + 心腦血管疾病�。� 參考：《濟(jì)南大學(xué)》2014年碩士論文

【摘要】：目的: 內(nèi)臟脂肪素（visfatin）是一種主要由內(nèi)臟脂肪組織分泌的細(xì)胞因子，其在肝臟、脾臟、骨髓、肌肉等多種組織器官中也均有表達(dá)�？山Y(jié)合并激活胰島素受體，，進(jìn)而發(fā)揮類胰島素樣降低血糖的作用，還參與機(jī)體脂類物質(zhì)的代謝、血管內(nèi)皮功能紊亂、血管再生、冠狀動(dòng)脈粥樣硬化以及缺血再灌注損傷等心腦血管疾病發(fā)生發(fā)展的病理生理過(guò)程，有可能成為心腦血管疾病新的防治靶點(diǎn)。本研究試圖通過(guò)分析內(nèi)臟脂肪素與傳統(tǒng)心腦血管疾病危險(xiǎn)因素之間的關(guān)系，驗(yàn)證其與相關(guān)心腦血管病危險(xiǎn)因素間一致性，為心腦血管病危險(xiǎn)因素及防控對(duì)策的研究提供依據(jù)。 方法: 課題組于2010年8月至9月在山東省寧陽(yáng)縣東疏鎮(zhèn)的49個(gè)行政村中，采用隨機(jī)整群抽樣的方法選取17個(gè)村中35-74歲所有常住居民共3500人作為調(diào)查對(duì)象。對(duì)全部調(diào)查對(duì)象進(jìn)行問(wèn)卷調(diào)查、體格測(cè)量及空腹血液標(biāo)本的檢測(cè)。采用Spearman相關(guān)性分析和多元線性逐步回歸分析，分析血漿內(nèi)臟脂肪素水平與收縮壓、舒張壓、空腹血糖、血脂四項(xiàng)、腰圍、體重指數(shù)、吸煙量、飲酒量等傳統(tǒng)心腦血管疾病危險(xiǎn)因素之間的關(guān)系，并分別比較高血壓、糖尿病、血脂異常、代謝綜合征等慢性疾病的患者與正常人群間血漿內(nèi)臟脂肪素水平的差異，以此來(lái)推斷內(nèi)臟脂肪素與心腦血管疾病之間的關(guān)系。 結(jié)果: （1）血漿內(nèi)臟脂肪素水平與體重、腰圍、腰高比、體重指數(shù)、舒張壓、空腹血糖、低密度脂蛋白膽固醇、甘油三酯及C反應(yīng)蛋白呈正相關(guān)（r=0.221、0.271、0.310、0.326、0.075、0.184、0.042、0.178、0.069，P＜0.05），與年齡、酒精攝入量、高密度脂蛋白膽固醇以及脈壓差呈負(fù)相關(guān)（r=-0.131、-0.173、-0.184、-0.048，P＜0.01），與總膽固醇、收縮壓、吸煙量未見(jiàn)明顯相關(guān)關(guān)系；（2）多元線性逐步回歸分析發(fā)現(xiàn)，體重指數(shù)、空腹血糖、甘油三脂、高密度脂蛋白膽固醇被納入回歸方程，為能夠影響血漿內(nèi)臟脂肪素水平的影響因素；（3）在糖尿病、高血壓、血脂異常、超重/肥胖及代謝綜合征等慢性疾病的患者中血漿內(nèi)臟脂肪素水平均顯著高于正常人群。 結(jié)論: 血漿內(nèi)臟脂肪素與傳統(tǒng)心腦血管疾病危險(xiǎn)因素間存在明顯的相關(guān)關(guān)系，各種與心腦血管疾病相關(guān)的慢性疾病的患者與正常人群相比，血漿內(nèi)臟脂肪素水平均顯著升高，提示內(nèi)臟脂肪素與心腦血管疾病的發(fā)生發(fā)展存在密切關(guān)系，或可成為心腦血管疾病防治的新靶點(diǎn)。但內(nèi)臟脂肪素對(duì)心腦血管疾病的具體作用機(jī)制尚不明確，其與心腦血管疾病間關(guān)系的確定仍需大樣本人群隊(duì)列研究進(jìn)行證實(shí)。
[Abstract]:Objective: visfatin is a cytokine secreted mainly by visceral adipose tissue. It is also expressed in liver, spleen, bone marrow, muscle and other tissues and organs. It can bind and activate insulin receptor, and then play the role of insulin-like hypoglycemia, also participate in the metabolism of lipid substances, vascular endothelial dysfunction, vascular regeneration, The pathophysiological process of cardiovascular and cerebrovascular diseases such as coronary atherosclerosis and ischemia-reperfusion injury may become a new target for the prevention and treatment of cardiovascular and cerebrovascular diseases. This study attempts to analyze the relationship between visceral fat and traditional cardiovascular and cerebrovascular disease risk factors, and to verify the consistency between visceral fat and related cardiovascular and cerebrovascular disease risk factors, so as to provide the basis for the study of cardiovascular and cerebrovascular disease risk factors and prevention and control countermeasures. Methods: from August to September 2010, 3500 residents aged 35-74 years were selected from 49 administrative villages in Dongshu Town, Ningyang County, Shandong Province. All subjects were investigated by questionnaire, physical measurement and fasting blood samples. Spearman correlation analysis and multiple linear stepwise regression analysis were used to analyze plasma visceral fat levels and systolic blood pressure, diastolic blood pressure, fasting blood glucose, blood lipids, waist circumference, body mass index and smoking. The relationship between the risk factors of traditional cardiovascular and cerebrovascular diseases, such as alcohol consumption, and the differences in plasma visceral fat levels between patients with hypertension, diabetes mellitus, dyslipidemia, metabolic syndrome and the normal population were compared. The relationship between visceral fat and cardiovascular and cerebrovascular diseases was inferred. Results: plasma visceral fat levels were positively correlated with body weight, waist circumference, waist height ratio, body mass index, diastolic blood pressure, fasting blood glucose, low density lipoprotein cholesterol, triglyceride and C-reactive protein (P < 0.05). Alcohol intake, high density lipoprotein cholesterol and pulse pressure difference were negatively correlated (P < 0.01). There was no significant correlation between alcohol intake, high density lipoprotein cholesterol and pulse pressure difference (P < 0.01). Triglyceride, high density lipoprotein cholesterol were incorporated into the regression equation for influencing plasma visceral fat levels in patients with diabetes, hypertension, and dyslipidemia. Plasma visceral fat levels in patients with overweight / obesity and metabolic syndrome were significantly higher than those in normal controls. Conclusion: there is a significant correlation between plasma visceral fat and the risk factors of traditional cardiovascular and cerebrovascular diseases. The level of visceral fat in plasma was significantly increased, which suggested that visceral adipotin was closely related to the occurrence and development of cardiovascular and cerebrovascular diseases, and might be a new target for the prevention and treatment of cardiovascular and cerebrovascular diseases. However, the mechanism of visceral fat on cardiovascular and cerebrovascular diseases is not clear, and the relationship between visceral and cerebrovascular diseases still needs to be confirmed by cohort study in large sample population.
【學(xué)位授予單位】：濟(jì)南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R54;R743

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