發(fā)布時(shí)間：2018-06-10 18:40

  本文選題：帕金森病 + 腦深部電刺激術(shù)��； 參考：《檢驗(yàn)醫(yī)學(xué)與臨床》2016年08期

【摘要】：目的應(yīng)用meta分析方法,綜合評(píng)價(jià)丘腦底核腦深部電刺激術(shù)(STN-DBS)治療帕金森病(PD)的臨床療效。方法檢索國(guó)內(nèi)關(guān)于腦深部電刺激術(shù)(DBS)治療PD的研究,對(duì)符合納入標(biāo)準(zhǔn)的文獻(xiàn)進(jìn)行meta分析。結(jié)果共納入9篇文獻(xiàn),總樣本量為226例,其中"藥物關(guān)"狀態(tài)下對(duì)統(tǒng)一帕金森病評(píng)分量表(UPDRS)Ⅲ進(jìn)行評(píng)分者226例,對(duì)UPDRSⅡ進(jìn)行評(píng)分者159例。"藥物開(kāi)"狀態(tài)下對(duì)UPDRSⅢ進(jìn)行評(píng)分者156例,對(duì)UPDRSⅡ進(jìn)行評(píng)分者102例。4種情況下STN-DBS前后合并指標(biāo)加權(quán)均數(shù)差(WMD)及其95%CI分別為25.85(16.82~34.88)、17.28(12.37~22.18)、4.29(2.56~6.02)、3.03(0.57~5.48)。meta分析合并結(jié)果顯示,"藥物開(kāi)"和"藥物關(guān)"狀態(tài)下,STN-DBS手術(shù)后UPDRSⅢ評(píng)分和UPDRSⅡ評(píng)分均比手術(shù)前顯著降低,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論STN-DBS用于治療PD,能有效改善運(yùn)動(dòng)不能、肌肉僵直、步態(tài)不穩(wěn)、姿勢(shì)平衡性和肌張力障礙、異動(dòng)癥等。
[Abstract]:Objective to evaluate the clinical efficacy of STN-DBS in the treatment of Parkinson's disease (PD) by meta analysis. Methods the domestic research on the treatment of PD by deep brain electrical stimulation (DBS) was searched and analyzed by meta. Results A total of 226 cases were included in 9 literatures, including 226 cases with uniform Parkinson's disease rating scale (UPDRS) 鈪，

本文編號(hào)：2004210