本文選題：高血壓病 + 腦血流動(dòng)力學(xué)��； 參考：《青島大學(xué)》2014年碩士論文

【摘要】：目的：研究高血壓病程與腦血流動(dòng)力學(xué)及腦白質(zhì)疏松的關(guān)系。 方法：按照高血壓病程長(zhǎng)短將實(shí)驗(yàn)收集的73例高血壓病病人分為四組：A組高血壓病程小于5年,B組高血壓病程5至10年,C組高血壓病程10至20年,D組高血壓病程大于20年。健康對(duì)照組74例。所有患者行經(jīng)顱多普勒超聲及顱腦MRI檢查,記錄MCA平均血流速度(Vm)、收縮期峰值血流速度(Vs)、舒張末血流速度(Vd)、搏動(dòng)指數(shù)(PI)及腦白質(zhì)疏松(LA)嚴(yán)重程度。根據(jù)Fazekas量表對(duì)LA的嚴(yán)重程度進(jìn)行半定量分析,分別對(duì)側(cè)腦室旁高信號(hào)(PVH)和雙側(cè)深部白質(zhì)高信號(hào)(DWMH)進(jìn)行評(píng)分。 結(jié)果：B組、C組的Vm、Vs較對(duì)照組顯著增快(p0.05)。D組的Vd較對(duì)照組顯著減慢(p0.05)、PI較對(duì)照組顯著增大(p0.05)。B組、C組、D組LA的總評(píng)分較對(duì)照組顯著增加(p0.05)。在高血壓患者中,年齡、病程、PI、Vd與LA存在明顯相關(guān)性�？刂颇挲g、病程、Vd后MCA-PI與LA仍相關(guān)。 結(jié)論：(1)高血壓患者腦血流速度先增快,隨著高血壓病程的增長(zhǎng),腦血流速度有逐漸減慢的趨勢(shì)。(2)MCA-PI與LA顯著相關(guān),并且能夠預(yù)測(cè)高血壓患者LA病變的嚴(yán)重程度。
[Abstract]:Objective: to study the relationship between the course of hypertension and cerebral hemodynamics and leukoaraiosis. Methods: according to the duration of hypertension, 73 patients with hypertension were divided into four groups: group A, group A, the course of hypertension was less than 5 years and group B, the course of hypertension in group C was 5 to 10 years, and the course of hypertension in group D was 10 to 20 years, and the course of hypertension in group D was more than 20 years. There were 74 cases in the healthy control group. All patients were examined by transcranial Doppler ultrasound and craniocerebral MRI to record the severity of MCA mean blood flow velocity (VMV), peak systolic velocity (VS), end-diastolic flow velocity (VDV), pulsatility index (Pi) and leukoaraiosis (LAA). According to the Fazekas scale, the severity of LA was semi-quantitatively analyzed, and the scores of hyperintense PVHs and hyperintense white matter in the bilateral deep white matter were scored respectively in the lateral paraventricular hyperintensity (PVHs) and bilateral deep white matter hyperintensity (DWMHs). Results compared with the control group, the VmTVs in the control group were significantly slower than those in the control group (P < 0.05). The total LA score of the C group was significantly higher than that of the control group (P 0.05). The total LA score of the C group was significantly higher than that of the control group (P 0.05), and that of the control group was significantly higher than that of the control group (P < 0.05), while that of the control group was significantly lower than that of the control group (P < 0.05). In patients with hypertension, there was a significant correlation between age, course of disease and LA. Control age, MCA-PI and LA were still correlated with the course of disease after VD. Conclusion (1) the cerebral blood flow velocity in hypertensive patients increased first, and with the increase of the course of hypertension, the cerebral blood flow velocity decreased gradually. MCA-PI was significantly correlated with LA and could predict the severity of LA lesions in hypertensive patients.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R544.1;R743

【共引文獻(xiàn)】

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1 張慧萍;張曉曼;邢濱;;缺血性腦白質(zhì)疏松癥與視網(wǎng)膜微血管改變的關(guān)系[J];廣東醫(yī)學(xué);2013年15期

2 成南;滕繼軍;;并發(fā)高血壓急性腦血管病病人腦微出血的研究[J];青島大學(xué)醫(yī)學(xué)院學(xué)報(bào);2013年05期

3 何金龍;牛廣明;韓曉東;葛麗紅;;SWI在糖尿病患者伴發(fā)腦內(nèi)微出血中的診斷應(yīng)用[J];放射學(xué)實(shí)踐;2013年12期

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7 何望生;楊文明;汪瀚;王曉e，

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