本文選題：帕金森病 + 抑郁　； 參考：《重慶醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：通過(guò)觀(guān)察帕金森病伴抑郁患者的腦血氧水平依賴(lài)信號(hào)(BOLD)的區(qū)域一致性（Regional homogeneity ReHo）和功能連通性的改變，以揭示帕金森病伴抑郁患者的神經(jīng)活動(dòng)特點(diǎn)及其病理生理機(jī)制。方法：納入41例帕金森病患者（Parkinson’s disease PD）和25例正常對(duì)照（normal control NC）。所有患者進(jìn)行漢密爾頓抑郁量表（HAMD）和自評(píng)抑郁量表（SDS）測(cè)定，進(jìn)一步將患者分成兩組：帕金森病伴抑郁組（PD patients with depression PDD）和帕金森病不伴抑郁組（non-depressed PD patients nD-PD）。l、采用靜息fMRI區(qū)域一致性作為測(cè)量指標(biāo)，進(jìn)行單因素方差分析（ANOVA）比較三組間ReHo值的差異。2、將ReHo值有顯著差異的腦區(qū)作為種子點(diǎn)，采用功能連接(functional connectivity，F(xiàn)C)方法，對(duì)比三組間的全腦功能網(wǎng)絡(luò)的改變。結(jié)果：與nD-PD組患者相比，，PDD組提示在左側(cè)額中回和右側(cè)額下回的區(qū)域一致性增高，而在左側(cè)杏仁核和雙側(cè)舌回降低。功能連接分析顯示伴抑郁癥狀的患者相比不伴抑郁的患者前額葉邊緣系統(tǒng)的功能連接減低，而在前額葉和舌回的功能連接增強(qiáng)。結(jié)論：PDD患者情緒調(diào)節(jié)網(wǎng)絡(luò)的腦功能有明顯改變和受損。多個(gè)腦區(qū)神經(jīng)活動(dòng)異常的可能是導(dǎo)致帕金森病伴抑郁的病理生理機(jī)制原因。
[Abstract]:Aim: to investigate the regional consistency and functional connectivity of cerebral oxygen level dependent signal (bod) in patients with Parkinson's disease (PD) and depression in order to reveal the characteristics of neural activity and its pathophysiological mechanism in PD patients with depression. Methods: 41 patients with Parkinson's disease (PD) and 25 normal controls (normal control NCV) were enrolled. All patients were measured with Hamilton Depression scale (Hamd) and self rating Depression scale (SDS). The patients were further divided into two groups: PD patients with depression PDD) in Parkinson's disease with depression group and non-depressed PD patients nD-PDD. L in Parkinson's disease with depression group. Resting fMRI region consistency was used as a measure index. Univariate ANOVA (ANOVA) was used to compare the differences of ReHo between the three groups. The brain regions with significant differences in ReHo values were used as seed points, and the functional connectivity (FCs) method was used to compare the changes of the whole brain functional networks among the three groups. Results: compared with nD-PD group, the regional consistency in left middle frontal gyrus and right inferior frontal gyrus was increased, but in left amygdala and bilateral lingual gyrus decreased. Functional junction analysis showed that the functional connections of the prefrontal limbic system in patients with depression were lower than those without depression, but the functional connections in the prefrontal lobe and lingual gyrus were enhanced. Conclusion the brain function of the emotional regulatory network in patients with 10-PDD was significantly changed and impaired. Abnormal neural activity in multiple brain regions may be the pathophysiological mechanism of Parkinson's disease with depression.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R742.5

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