發(fā)布時(shí)間：2018-05-07 01:24

  本文選題：膠質(zhì)瘤 + 生物標(biāo)志物��； 參考：《中國臨床藥理學(xué)與治療學(xué)》2016年01期

【摘要】：彌漫性膠質(zhì)瘤是成人中最常見的原發(fā)性中樞神經(jīng)系統(tǒng)腫瘤,分為星形細(xì)胞瘤、少突膠質(zhì)細(xì)胞瘤和少突星形細(xì)胞瘤,病理級別為Ⅱ~Ⅳ級,其中Ⅳ級的膠質(zhì)母細(xì)胞瘤是最常見的高級別膠質(zhì)瘤。傳統(tǒng)上彌漫性膠質(zhì)瘤的診斷主要是基于其組織病理學(xué)特征,但是仍有很多生物學(xué)特點(diǎn)無法很好地解釋。而以異檸檬酸脫氫酶(IDH)為代表的生物標(biāo)志物已被證明對腦膠質(zhì)瘤分子特征的分類和患者預(yù)后情況都有不可忽視的作用。IDH在成人Ⅱ級和Ⅲ級彌漫性膠質(zhì)瘤及繼發(fā)性膠質(zhì)母細(xì)胞瘤中突變頻率較高。IDH突變的浸潤性星形細(xì)胞瘤和繼發(fā)性膠質(zhì)母細(xì)胞瘤具有TP53和ATRX突變的特點(diǎn)。少突膠質(zhì)細(xì)胞瘤也伴隨IDH突變并以1p/19q聯(lián)合性缺失和CIC、FUBP1、Notch1、TERT啟動子突變?yōu)樘卣�。膠質(zhì)瘤的生物標(biāo)志物有望成為臨床診斷的新標(biāo)準(zhǔn)。
[Abstract]:Diffuse gliomas are the most common primary central nervous system tumors in adults. They are divided into astrocytoma, oligodendrocytoma and oligodendrocytoma. Grade IV glioblastoma is the most common high grade glioma. Traditionally, the diagnosis of diffuse glioma is mainly based on its histopathological features, but there are still many biological characteristics that can not be explained well. However, the biomarker represented by isocitrate dehydrogenase (IDH) has been proved to play an important role in the classification of glioma molecular characteristics and the prognosis of the patients. IDH plays an important role in diffuse gliomas and secondary gliomas of grade 鈪，

本文編號：1854780