本文選題：腦性癱瘓 + 彌散張量成像　； 參考：《生物醫(yī)學(xué)工程學(xué)雜志》2017年05期

【摘要】：本文使用彌散張量成像及白質(zhì)纖維束追蹤技術(shù)構(gòu)建和分析了15名腦性癱瘓患兒和30名正常嬰兒大腦的白質(zhì)腦網(wǎng)絡(luò),發(fā)現(xiàn)腦性癱瘓患兒和正常嬰兒的白質(zhì)腦網(wǎng)絡(luò)都具有"小世界"屬性,但患兒的最短路徑長度明顯變長,而標(biāo)準(zhǔn)聚類系數(shù)、全局效率和局部效率明顯下降。此外,我們還發(fā)現(xiàn)左腦楔葉、左右腦楔前葉以及左腦扣帶回后部是嬰兒白質(zhì)腦網(wǎng)絡(luò)的核心節(jié)點,患兒白質(zhì)腦網(wǎng)絡(luò)的部分節(jié)點存在異常,且異常節(jié)點多集中于顳葉、枕葉和頂葉。本文結(jié)果表明腦性癱瘓嬰兒的白質(zhì)腦網(wǎng)絡(luò)已經(jīng)出現(xiàn)紊亂的現(xiàn)象,這為我們進(jìn)一步研究腦性癱瘓兒童的發(fā)病機(jī)制提供了幫助。
[Abstract]:The white matter brain network of 15 children with cerebral palsy and 30 normal infants was constructed and analyzed by using diffusion Zhang Liang imaging and white matter fiber tracer technique. It was found that the white matter brain network of both children with cerebral palsy and normal infants had the attribute of "small world", but the shortest path length of children became longer, while the standard clustering coefficient, global efficiency and local efficiency decreased obviously. In addition, we also found that the left cuneate lobe, the left and right precuneal lobe and the posterior cingulate gyrus of the left brain are the core nodes of the white matter brain network in infants. Some of the nodes of the white matter brain network in children are abnormal, and the abnormal nodes are mainly concentrated in the temporal lobe, occipital lobe and parietal lobe. The results show that the white matter network of infants with cerebral palsy has been disordered, which is helpful for us to study the pathogenesis of cerebral palsy in children with cerebral palsy.
【作者單位】： 上海理工大學(xué)醫(yī)療器械與食品學(xué)院;
【基金】：國家自然科學(xué)基金(61201067) 微創(chuàng)勵志創(chuàng)新基金(YS30809134)
【分類號】：O157.5;R742.3
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本文編號：1845636