本文選題：膠質(zhì)母細(xì)胞瘤 + 多形性��； 參考：《中國微侵襲神經(jīng)外科雜志》2013年08期

【摘要】：目的探討多形性膠質(zhì)母細(xì)胞瘤(GBM)預(yù)后相關(guān)的臨床因素。方法回顧性分析160例隨訪資料完整的GBM,采用Kaplan-Meier法計算生存率及進(jìn)行單因素分析,Log-rank法進(jìn)行生存率顯著性檢驗,Cox比例風(fēng)險回歸模型作多因素分析。結(jié)果本組病人術(shù)后1年、2年、5年生存率分別是65.3%、34.1%、9.1%。單因素分析顯示年齡、腫瘤切除程度、治療方式是影響GBM生存率的因素。多因素分析顯示年齡、腫瘤部位、腫瘤切除程度及治療方式是與GBM預(yù)后相關(guān)的獨立因素。結(jié)論年齡、腫瘤部位、腫瘤切除程度和治療方式是影響GBM預(yù)后的主要因素,積極的手術(shù)治療和規(guī)范化、個體化的綜合治療可有效提高GBM病人的生存率。
[Abstract]:Objective to investigate the prognostic factors of glioblastoma multiforme (GBM). Methods one hundred and sixty cases of GBM with complete follow-up data were analyzed retrospectively. The survival rate was calculated by Kaplan-Meier method and the survival rate was tested by univariate analysis Log-rank method. The Cox proportional risk regression model was used for multivariate analysis. Results the 1 year, 2 year and 5 year survival rates of these patients were 65.3% and 34.1%, respectively. Univariate analysis showed that age, tumor resection and treatment were the factors affecting GBM survival rate. Multivariate analysis showed that age, tumor location, degree of tumor resection and treatment were independent factors related to prognosis of GBM. Conclusion Age, tumor location, degree of tumor resection and treatment are the main factors that affect the prognosis of GBM. Active surgical treatment and standardized, individualized combined therapy can effectively improve the survival rate of GBM patients.
【作者單位】： 貴陽市第二人民醫(yī)院神經(jīng)外科;首都醫(yī)科大學(xué)附屬北京天壇醫(yī)院神經(jīng)外科中心;廣東同江醫(yī)院神經(jīng)外科;
【基金】：衛(wèi)生行業(yè)科研專項基金(編號:200902004) 首都醫(yī)學(xué)發(fā)展科研基金(編號:2009-1040)
【分類號】：R739.41

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