發(fā)布時(shí)間：2018-03-22 04:09

  本文選題：青少年　切入點(diǎn)：癲癇　出處：《中國(guó)醫(yī)學(xué)影像技術(shù)》2017年06期 　論文類(lèi)型：期刊論文

【摘要】：青少年肌陣攣癲癇是一種特發(fā)性全面性癲癇綜合征,對(duì)其診斷主要依靠病史、臨床癥狀和腦電圖,常規(guī)影像學(xué)檢查未見(jiàn)腦內(nèi)器質(zhì)性病變。MRS可無(wú)創(chuàng)地定量測(cè)定腦內(nèi)神經(jīng)代謝物濃度,評(píng)估患者大腦代謝改變。目前,丘腦—皮質(zhì)網(wǎng)絡(luò)功能障礙是本病的研究熱點(diǎn),該網(wǎng)絡(luò)中存在神經(jīng)代謝物濃度改變以及神經(jīng)遞質(zhì)谷氨酸和γ-氨基丁酸代謝失衡。而癲癇的發(fā)病與腦內(nèi)興奮性和抑制性氨基酸的比例失衡有關(guān),且癲癇發(fā)作可引起神經(jīng)元損傷,導(dǎo)致神經(jīng)元相關(guān)代謝產(chǎn)物濃度改變。本文將物質(zhì)代謝、神經(jīng)結(jié)構(gòu)和功能相結(jié)合,對(duì)青少年肌陣攣癲癇患者的磁共振波譜研究進(jìn)行綜述。
[Abstract]:Juvenile myoclonic epilepsy is an idiopathic generalized epilepsy syndrome, the diagnosis mainly depends on medical history, clinical symptoms and EEG, conventional imaging examinations showed no pathological changes in the brain.MRS is a noninvasive determination of metabolite concentration in brain nerve quantitatively, change the evaluation of patients with brain metabolism. At present, thalamocortical network dysfunction is the research focus of this disease, there are nerve metabolic changes and neurotransmitter glutamate and GABA metabolic imbalance in the network. And the incidence of epilepsy and brain excitatory and inhibitory amino acid imbalance, and seizures can cause neuronal damage, leading to neuronal related metabolites. This paper will change metabolism, nerve structure and function combination, carries on the summary to the study of magnetic resonance spectroscopy in juvenile myoclonic epilepsy.

【作者單位】： 南京大學(xué)醫(yī)學(xué)院;南京大學(xué)醫(yī)學(xué)院附屬鼓樓醫(yī)院醫(yī)學(xué)影像科;
【基金】：國(guó)家自然科學(xué)基金青年基金(81301198、81300925)、國(guó)家自然科學(xué)基金面上項(xiàng)目(81571040)
【分類(lèi)號(hào)】：R445.2;R742.1

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本文編號(hào)：1646979