本文選題：胸腺瘤　切入點(diǎn)：胸腺增生　出處：《中國(guó)康復(fù)理論與實(shí)踐》2017年12期 　論文類型：期刊論文

【摘要】：目的分析伴胸腺瘤或胸腺增生的重癥肌無力患者臨床特點(diǎn)及預(yù)后。方法回顧性分析2007年1月至2016年12月伴胸腺瘤重癥肌無力患者118例和伴胸腺增生重癥肌無力患者42例,統(tǒng)計(jì)并比較兩組發(fā)病年齡、性別、首發(fā)癥狀、臨床分型、受累肌群、肌無力危象、低頻重復(fù)神經(jīng)電刺激及完全穩(wěn)定緩解資料。結(jié)果與伴胸腺增生重癥肌無力患者相比,伴胸腺瘤重癥肌無力患者平均發(fā)病年齡大,Ⅲ型比例高,術(shù)后完全穩(wěn)定緩解率低(P0.05),更易發(fā)生呼吸肌受累(χ~2=6.364,P=0.011)及肌無力危象(χ~2=5.455,P=0.022)。不同病理分型胸腺瘤伴發(fā)的重癥肌無力患者之間呼吸肌受累(χ~2=8.532,P=0.036)和肌無力危象(χ~2=8.956,P=0.030)發(fā)生率存在顯著性差異,以B3型最高,A+AB型最低。伴胸腺瘤重癥肌無力患者重復(fù)神經(jīng)電刺激陽性率高于伴胸腺增生重癥肌無力患者,但無顯著性差異(χ~21.357,P0.05);不同病理分型胸腺瘤重癥肌無力患者有上升趨勢(shì),但無顯著性差異(χ~26.623,P0.05)。結(jié)論伴胸腺瘤重癥肌無力多見于中老年人,臨床癥狀重,易有呼吸肌受累和肌無力危象,伴胸腺增生重癥肌無力更能從手術(shù)中獲益。重癥肌無力低頻重復(fù)神經(jīng)電刺激陽性率與胸腺病變類型無明顯關(guān)聯(lián)。重癥肌無力呼吸肌受累和肌無力危象與胸腺瘤病理分型有關(guān)。
[Abstract]:Objective to analyze the clinical characteristics and prognosis of myasthenia gravis patients with thymoma or thymic hyperplasia. Methods from January 2007 to December 2016, 118 patients with thymoma myasthenia gravis and 42 patients with thymic hyperplasia myasthenia gravis were retrospectively analyzed. The age, sex, initial symptom, clinical type, muscle group, myasthenia crisis, low frequency repetitive nerve stimulation and complete stable remission of the two groups were statistically analyzed and compared with those of the patients with thymic hyperplasia myasthenia gravis. The average age of myasthenia gravis patients with thymoma was older and the proportion of type 鈪，

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